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溴氯甲烷

溴氯甲烷用途

【用途一】
用于制药
【用途二】
溴氯甲烷作为医药、农药、杀菌剂、水处理剂等的中间体。

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溴氯甲烷名称

[ CAS 号 ]:
74-97-5

[ 中文名 ]:
溴氯甲烷

[ 英文名 ]:
Bromochloromethane

[中文别名 ]:

氯溴甲烷

[英文别名 ]:

bromochlorometane
EINECS 200-826-3
chloromethyl benzyl succinate
chlorobromomethane
monobromomonochloromethane
Methane, bromochloro-
Butanedioic acid,chloromethyl phenylmethyl ester
succinic acid benzyl ester chloromethyl ester
benzyl chloromethyl butanedioate
Bromochloromethane [UN1887] [Poison]

溴氯甲烷物理化学性质

[ 密度 ]:
1.9±0.1 g/cm3

[ 沸点 ]:
65.1±8.0 °C at 760 mmHg

[ 熔点 ]:
−88 °C(lit.)

[ 分子式 ]:
CH₂BrCl

[ 分子量 ]:
129.384

[ 闪点 ]:
-22.9±8.5 °C

[ 精确质量 ]:
127.902832

[ LogP ]:
1.41

[ 外观性状 ]:
白色至淡黄色晶体粉末

[ 蒸汽密度 ]:
4.5 (vs air)

[ 蒸汽压 ]:
172.3±0.1 mmHg at 25°C

[ 折射率 ]:
1.466

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 稳定性 ]:
Stable, but may discolour in light. Incompatible with aluminium, magnesium, zinc, calcium, strong oxidizing agents.

[ 水溶解性 ]:
9 g/L (20 ºC)

溴氯甲烷MSDS

溴氯甲烷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PA5250000

CHEMICAL NAME :: Methane, bromochloro-

CAS REGISTRY NUMBER :: 74-97-5

BEILSTEIN REFERENCE NO. :: 1730801

LAST UPDATED :: 199712

DATA ITEMS CITED :: 40

MOLECULAR FORMULA :: C-H2-Br-Cl

MOLECULAR WEIGHT :: 129.39

WISWESSER LINE NOTATION :: G1E

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 28800 ppm/15M

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - altered sleep time (including change in righting reflex) Behavioral - tremor

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4300 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12030 mg/m3/7H

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >20 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1000 ppm/7H/16W-I

TOXIC EFFECTS :: Liver - fatty liver degeneration Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - changes in metals, not otherwise specified

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 ppm/6H/26W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - changes in metals, not otherwise specified

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 500 ppm/6H/26W-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - changes in metals, not otherwise specified

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1000 ppm/7H/16W-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - changes in metals, not otherwise specified

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Lung

REFERENCE :: TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981- Volume(issue)/page/year: 13,205,1987 *** REVIEWS *** ACGIH TLV-TWA 1060 mg/m3 (200 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 200 ppm (1050 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,50,1971 OSHA PEL (Gen Indu):8H TWA 200 ppm (1050 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 200 ppm (1050 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 200 ppm (1050 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 200 ppm (1050 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 200 ppm (1050 mg/m3);STEL 250 ppm (1300 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 200 ppm (1050 mg/m3) JAN 1993 OEL-DENMARK:TWA 200 ppm (1050 mg/m3) JAN 1993 OEL-FINLAND:TWA 200 ppm (1050 mg/m3);STEL 250 ppm (1315 mg/m3) JAN 1993 OEL-FRANCE:TWA 200 ppm (1050 mg/m3) JAN 1993 OEL-GERMANY:TWA 200 ppm (1050 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 200 ppm (1050 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 200 ppm (1050 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 200 ppm (1050 mg/m3);STEL 400 ppm JAN 1993 OEL-TURKEY:TWA 200 ppm (1050 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 200 ppm (1050 mg/m3);STEL 250 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO CHLOROBROMOMETHANE-air:10H TWA 200 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 18250 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 56 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 18250 No. of Facilities: 35 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 71 (estimated)

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溴氯甲烷安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H315-H318-H332-H335-H420

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R20;R36/37/38;R59

[ 安全声明 (欧洲) ]:
S26-S39-S59-S37/39-S45-S36/37

[ 危险品运输编码 ]:
UN 1887 6.1/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
PA5250000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2903799090

溴氯甲烷合成路线

溴氯甲烷上下游产品

溴氯甲烷上游产品

溴氯甲烷下游产品

溴氯甲烷海关

[ 海关编码 ]: 2903799090

[ 中文概述 ]:
2903799090 其他无环烃卤化衍生物（含二种或三种以上不同卤素）。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ Summary ]:
2903799090 halogenated derivatives of acyclic hydrocarbons containing two or more different halogens。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

溴氯甲烷文献

Predicting vehicle effects on the dermal absorption of halogenated methanes using physiologically based modeling.

Toxicol. Sci. 48(2) , 180-8, (1999)

Occupational and environmental settings present opportunities for humans to come into contact with a variety of chemicals via the dermal route. The chemicals contacting the skin are likely to be dilut...

Effect of bromochloromethane on methane emission, rumen fermentation pattern, milk yield, and fatty acid profile in lactating dairy goats.

J. Dairy Sci. 95(4) , 2027-36, (2012)

Several technologies have been tested to reduce enteric methanogenesis, but very few have been successfully used in practical conditions for livestock. Furthermore, the consequences of reduced rumen m...

Effect of isoniazid or phenobarbital pretreatment on the metabolism of dihalomethanes to carbon monoxide.

Pol. J. Occup. Med. Environ. Health 5(3) , 245-50, (1992)

An oral dose of 6.2 mmoles of diachloromethane (DCM), bromochloromethane (BCM) or dibromomethane (DBM) per kg body mass yielded a maximum carboxyhemoglobin (COHb) level of about 9% (at 6 hr), 11% (at ...

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