1-(4-氯苄基)-2-甲基苯并咪唑盐酸盐

1-(4-氯苄基)-2-甲基苯并咪唑盐酸盐用途

Chlormidazole hydrochloride 是一种抗真菌剂 ( antifungal agent),对多种真菌和部分革兰氏阳性球菌有抑制活性。Chlormidazole hydrochloride 可用于指甲和皮肤的真菌和细菌感染,包括指间和甲周真菌。

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1-(4-氯苄基)-2-甲基苯并咪唑盐酸盐名称

[ CAS 号 ]:
74298-63-8

[ 中文名 ]:
1-(4-氯苄基)-2-甲基苯并咪唑盐酸盐

[ 英文名 ]:
Chlormidazole hydrochloride

[英文别名 ]:

chloromethyl-trimethyl stannane
Trimethyl-chlormethyl-stannan
Chlorimidazole hydrochloride
Chlormethyl-trimethyl-zinn
Chlormethyl-trimethyl-stannan
chlormidazole hydrochloride
chloromethyl-trimethyl tin
Chlormethylen-trimethylzinn

1-(4-氯苄基)-2-甲基苯并咪唑盐酸盐生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 真菌

[ 靶点 ]

IC50: fungal[1]

[参考文献]

[1]. Daniel J. Sheehan, et al. Current and Emerging Azole Antifungal Agents. Clin Microbiol Rev. 1999 Jan; 12(1): 40–79.

1-(4-氯苄基)-2-甲基苯并咪唑盐酸盐物理化学性质

[ 沸点 ]:
467.5ºC at 760 mmHg

[ 分子式 ]:
C₁₅H₁₄Cl₂N₂

[ 分子量 ]:
293.19100

[ 闪点 ]:
236.5ºC

[ 精确质量 ]:
292.05300

[ PSA ]:
17.82000

[ LogP ]:
4.84840

[ 外观性状 ]:
固体

[ 储存条件 ]:
-20°C

1-(4-氯苄基)-2-甲基苯并咪唑盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DD6700000

CHEMICAL NAME :: Benzimidazole, 1-(p-chlorobenzyl)-2-methyl-, hydrochloride

CAS REGISTRY NUMBER :: 74298-63-8

LAST UPDATED :: 199112

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C15-H13-Cl-N2.Cl-H

MOLECULAR WEIGHT :: 293.21

WISWESSER LINE NOTATION :: T56 BN DNJ B1R DG& C1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,489,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 58 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,489,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,489,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,489,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,489,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,489,1959