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Sauvagine

Sauvagine用途

Sauvagine,是一种来自青蛙皮肤的 40 个氨基酸的神经肽,是哺乳动物 CRF 激动剂。Sauvagine 可有效从大鼠垂体细胞释放 ACTH。Sauvagine 在利尿,心血管系统和内分泌腺体方面具有许多药理作用。

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Sauvagine名称

[ CAS 号 ]:
74434-59-6

[ 英文名 ]:
Sauvagine TFA

[英文别名 ]:

Pyr-GPPISIDLSLELLRKMIEIEKQEKEKQQAANNRLLLDTI-NH2

Sauvagine生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 心血管疾病

研究领域 >> 内分泌

信号通路 >> G 蛋白偶联受体/G 蛋白 >> CRFR

研究领域 >> 神经疾病

[参考文献]

[1]. David A Lovejoy, et al. Evolution and phylogeny of the corticotropin-releasing factor (CRF) family of peptides: expansion and specialization in the vertebrates. J Chem Neuroanat. 2013 Dec;54:50-6.

[2]. P C Montecucchi, et al. Amino acid composition and sequence analysis of sauvagine, a new active peptide from the skin of Phyllomedusa sauvagei. Int J Pept Protein Res. 1981 Aug;18(2):113-20.

[3]. M H Perrin, et al. Corticotropin releasing factor receptors and their ligand family. Ann N Y Acad Sci. 1999 Oct 20;885:312-28.

Sauvagine物理化学性质

[ 分子式 ]:
C₂₀₂H₃₄₆N₅₆O₆₃S

[ 分子量 ]:
3334.68

[ 储存条件 ]:
2-8°C，密封，干燥

Sauvagine安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

Sauvagine文献

Differential activation of CRF receptor subtypes removes stress-induced memory deficit and anxiety.

Eur. J. Neurosci. 25(11) , 3385-97, (2007)

The objective of this study was to investigate the role of corticotropin-releasing factor receptors 1 (CRF(1)) and 2 (CRF(2)) in anxiety-like behavior and learning of C57BL/6J mice after exposure to a...

Exploring the binding site crevice of a family B G protein-coupled receptor, the type 1 corticotropin releasing factor receptor.

Mol. Pharmacol. 78(4) , 785-93, (2010)

Family B of G protein-coupled receptors (GPCRs) is composed of receptors that bind peptides, such as secretin, glucagon, parathyroid hormone, and corticotropin releasing factor (CRF), which play criti...

Cardiovascular responses to microinjections of urocortin 3 into the nucleus tractus solitarius of the rat.

Am. J. Physiol. Heart Circ. Physiol. 296(2) , H325-32, (2009)

Urocortin 3 (Ucn3) is a new member of the corticotropin-releasing factor (CRF) peptide family and is considered to be a specific and endogenous ligand for CRF type 2 receptors (CRF2Rs). The presence o...

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