1-UFT protocol

1-UFT protocol用途

替加氟尿嘧啶是一种口服活性氟嘧啶类抗癌药物。替加氟尿嘧啶抑制胸苷酸合成酶。替加氟尿嘧啶可用于研究抗实体瘤[1]。
点击显示

1-UFT protocol名称

[ CAS 号 ]:
74578-38-4

[ 英文名 ]:
1-UFT protocol

[英文别名 ]:

1-UFT protocol生物活性

[ 描述 ]:

替加氟尿嘧啶是一种口服活性氟嘧啶类抗癌药物。替加氟尿嘧啶抑制胸苷酸合成酶。替加氟尿嘧啶可用于研究抗实体瘤[1]。

[ 相关类别 ]:

研究领域 >> 癌症
信号通路 >> 其他 >> 其他

[参考文献]

[1]. Casado E, et al. UFT (tegafur-uracil) in rectal cancer. Ann Oncol. 2008;19(8):1371-1378.

1-UFT protocol物理化学性质

[ 沸点 ]:
467.1ºC at 760 mmHg

[ 分子式 ]:
C12H13FN4O5

[ 分子量 ]:
312.25

[ 闪点 ]:
236.3ºC

[ 精确质量 ]:
312.08700

[ PSA ]:
130.59000

[ LogP ]:
0.28480

1-UFT protocol毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YR0480000
CAS REGISTRY NUMBER :
74578-38-4
LAST UPDATED :
198910
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C8-H9-F-N2-O3.4C4-H4-N2-O2
MOLECULAR WEIGHT :
648.59
WISWESSER LINE NOTATION :
T6NVMVJ EF A- BT5OTJ &T6MVMVJ 4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1580 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea Blood - other changes
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 20,1009,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1275 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea Blood - other changes
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 20,1009,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Vascular - other changes Gastrointestinal - nausea or vomiting
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 20,1009,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
242 mg/kg
TOXIC EFFECTS :
Vascular - other changes
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 20,1009,1980 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
713 mg/kg
SEX/DURATION :
female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 22,85,1981
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
891 mg/kg
SEX/DURATION :
female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 22,85,1981
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2503 mg/kg
SEX/DURATION :
female 7-22 day(s) after conception lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 22,109,1981
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
875 mg/kg
SEX/DURATION :
female 7-22 day(s) after conception lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 22,109,1981
点击显示

推荐生产厂家/供应商：

暂无推荐供应商。请联系客服获知如何成为推荐供应商。

相关化合物

[1-UFT protocol]化源网提供1-UFT protocolCAS号74578-38-4，1-UFT protocolMSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询1-UFT protocol上化源网，专业又轻松。>>电脑版：1-UFT protocol

标题：【1-UFT protocol】1-UFT protocol CAS号:74578-38-4【结构式 性质 活性】-化源网 地址：https://m.chemsrc.com/mip/cas/74578-38-4_525522.html