三氯溴甲烷

用途一；用于有机合成。

[ 密度 ]:
2.012 g/mL at 25 °C(lit.)

[ 沸点 ]:
105 °C(lit.)

[ 熔点 ]:
−6 °C(lit.)

[ 分子式 ]:
CBrCl₃

[ 分子量 ]:
198.27400

[ 闪点 ]:
104-105°C

[ 精确质量 ]:
195.82500

[ LogP ]:
2.70900

[ 外观性状 ]:
无色液体像氯仿一样的气味

[ 蒸汽密度 ]:
6.85 (vs air)

[ 蒸汽压 ]:
38.4 mm Hg ( 25 °C)

[ 折射率 ]:
n20/D 1.5065(lit.)

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放

[ 水溶解性 ]:
insoluble

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :

PA5400000

CHEMICAL NAME :

Methane, bromotrichloro-

CAS REGISTRY NUMBER :

75-62-7

BEILSTEIN REFERENCE NO. :

1732543

LAST UPDATED :

199710

DATA ITEMS CITED :

11

MOLECULAR FORMULA :

C-Br-Cl3

MOLECULAR WEIGHT :

198.27

WISWESSER LINE NOTATION :

GXGGE

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

100 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

119 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity)

MUTATION DATA

TYPE OF TEST :

DNA adduct

TEST SYSTEM :

Mammal - species unspecified Lymphocyte

DOSE/DURATION :

1 mmol/L

REFERENCE :

TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 11,243,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1152 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 34 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1152 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1822 (estimated) No. of Female Employees: 272 (estimated)

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302 + H312 + H332

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22;R36/37/38

[ 安全声明 (欧洲) ]:
S36/37-S36/37/39-S26

[ 危险品运输编码 ]:
UN 2810 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
PA5400000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29034700

详细合成路线

三氯溴甲烷上游产品

三氯溴甲烷下游产品

1.将无水三溴化铝和干燥四氯化碳一起回流，可得溴三氯甲烷 （产率51.4%)，副产二溴二氯甲烷。

2.制法：

于装有搅拌器、回流冷凝器的反应瓶中，加入无水溴化铝168.5g，四氯化碳940。搅拌下加热回流45min。冷后抽滤。滤液5%的碳酸钠溶液洗涤，再水洗2次。无水氯化钙干燥。分馏，先蒸出四氯化碳约480mL，再得到约8g二溴二氯甲烷，最后收集102～106℃，得化合物(1)193g,收率51.4%。

[ 海关编码 ]: 29034700

Increased proteolysis after single-dose exposure with hepatotoxins in HepG2 cells.

Free Radic. Biol. Med. 33(2) , 283-91, (2002)

Chronic ethanol consumption is associated with increased protein oxidation and decreased proteolysis in the liver. We tested the hypothesis that even single-dose treatment with ethanol or bromotrichlo...

Suicidal inactivation of haemoproteins by reductive metabolites of halomethanes: a structure-activity relationship study.

Toxicology 100(1-3) , 175-83, (1995)

Human haemoglobin (Hb), methaemalbumin (MHA) or rat liver microsomal cytochrome P-450 (P-450) were incubated anaerobically at microM concentrations with 1 mM carbon tetrachloride (CCl4), trichlorobrom...

Use of rat liver slices for the study of oxidative DNA damage in comparison with isolated rat liver nuclei and HepG2 human hepatoma cells.

Food Chem. Toxicol. 38(5) , 451-8, (2000)

Tissue slices are a useful biological system for lipid peroxidation studies but their use for DNA damage studies is not well characterized. Hence, the present study investigates DNA damage in rat live...

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公司名：上海化源生化科技有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：三氯溴甲烷

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公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥1748.0/500g ￥448.0/100g ￥78.0/25g

联系人：刘佳

产品详情：三氯溴甲烷

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公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥339.9/100g ￥100.9/25g ￥1438.9/500g ￥需询单/1g

联系人：阿拉丁

产品详情：三氯溴甲烷

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公司名：广东翁江化学试剂有限公司

区域：韶关市翁源县

价格：
￥1400.0/500g ￥120.0/25g ￥400.0/100g

联系人：朱丽丹

产品详情：三氯溴甲烷

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