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2-[(4-羟基-6-苯基嘧啶-2-基)硫代]-1-(4-硝基苯)乙基-1-酮

用途

Albendazole sulfone 是 Albendazole 的代谢产物,具有抗寄生虫活性。

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名称

[ CAS 号 ]:
75184-71-3

[ 中文名 ]:
阿苯达唑砜

[ 英文名 ]:
Albendazole sulfone

[中文别名 ]:

[英文别名 ]:

albendazole sulfone

生物活性

[ 描述 ]:

Albendazole sulfone 是 Albendazole 的代谢产物,具有抗寄生虫活性。

[ 相关类别 ]:

研究领域 >> 感染

[参考文献]

[1]. Ingold K, et, al. Efficacies of albendazole sulfoxide and albendazole sulfone against In vitro-cultivated Echinococcus multilocularis metacestodes. Antimicrob Agents Chemother. 1999 May;43(5):1052-61.

[2]. Adas G, et, al. Use of albendazole sulfoxide, albendazole sulfone, and combined solutions as scolicidal agents on hydatid cysts (in vitro study). World J Gastroenterol. 2009 Jan 7;15(1):112-6.

物理化学性质

[ 密度 ]:
1.42g/cm3

[ 熔点 ]:
290-292ºC

[ 分子式 ]:
C₁₂H₁₅N₃O₄S

[ 分子量 ]:
297.33000

[ 精确质量 ]:
297.07800

[ PSA ]:
109.53000

[ LogP ]:
3.07870

[ 折射率 ]:
1.619

[ 储存条件 ]:
-20°C Freezer

[ 水溶解性 ]:
Soluble in DMSO, and methanol.

MSDS

详细MSDS(安全技术说明书)

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DD6520700

CHEMICAL NAME :: 2-Benzimidazolecarbamic acid, 5-(propylsulfonyl)-, methyl ester

CAS REGISTRY NUMBER :: 75184-71-3

LAST UPDATED :: 198910

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C12-H15-N3-O4-S

MOLECULAR WEIGHT :: 297.36

WISWESSER LINE NOTATION :: T56 BM DNJ CMVO1 GSW3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 75 mg/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: ARCVBP Annales Recherches Veterinaires. (Institut National de la Recherche Agronomique, Service des Publ., Route de Saint-Cyr, 78000 Versailles, France) V.1- 1970- Volume(issue)/page/year: 12,159,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 75 mg/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: ARCVBP Annales Recherches Veterinaires. (Institut National de la Recherche Agronomique, Service des Publ., Route de Saint-Cyr, 78000 Versailles, France) V.1- 1970- Volume(issue)/page/year: 12,159,1981

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安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H361d

[ 警示性声明 ]:
P281-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
63-36/38

[ 安全声明 (欧洲) ]:
26-36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
DD6520700

[ 海关编码 ]:
29339900

文献

Development and validation of an ultra high performance liquid chromatography tandem mass spectrometry method for simultaneous determination of sulfonamides, quinolones and benzimidazoles in bovine milk.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 962 , 20-9, (2014)

A simple, sensitive and reliable analytical method was developed for the simultaneous determination of 38 veterinary drugs (18 sulfonamides, 11 quinolones and 9 benzimidazoles) and 8 metabolites of be...

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