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N-2-羟乙基哌嗪-N'-2-乙磺酸钠盐

N-2-羟乙基哌嗪-N'-2-乙磺酸钠盐用途

HEPES钠是一种非挥发性两性离子化学缓冲剂,广泛应用于细胞培养。HEPES钠在pH 6.8至8.2时有效。HEPES钠盐也是溶酶体生物生成的有效诱导剂[1][2][3]。

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N-2-羟乙基哌嗪-N'-2-乙磺酸钠盐名称

[ CAS 号 ]:
75277-39-3

[ 中文名 ]:
HEPES 钠

[ 英文名 ]:
HEPES sodium salt

[中文别名 ]:

[英文别名 ]:

HEPES sodium salt
EINECS 278-169-7
MFCD00036463

N-2-羟乙基哌嗪-N'-2-乙磺酸钠盐生物活性

[ 描述 ]:

HEPES钠是一种非挥发性两性离子化学缓冲剂,广泛应用于细胞培养。HEPES钠在pH 6.8至8.2时有效。HEPES钠盐也是溶酶体生物生成的有效诱导剂[1][2][3]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

HEPES保持钛的超亲水性至少3个月,并导致生物活性和骨传导性的持续保持[1]。HEPES驱动溶酶体生物生成,影响MiT/TFE细胞质核分布,破坏细胞整体转录谱,导致培养的RAW264.7细胞中MiT/TFE依赖的溶酶体自噬基因网络激活[3]。

[参考文献]

[1]. Suzuki T, et al. Nonvolatile buffer coating of titanium to prevent its biological aging and for drug delivery. Biomaterials. 2010;31(18):4818-4828.

[2]. Sledź P, et al. An experimental charge density of HEPES. Acta Crystallogr B. 2010;66(Pt 4):482-492.

[3]. https://pubmed.ncbi.nlm.nih.gov/20631430/

N-2-羟乙基哌嗪-N'-2-乙磺酸钠盐物理化学性质

[ 熔点 ]:
234ºC

[ 分子式 ]:
C₈H₁₇N₂NaO₄S

[ 分子量 ]:
260.286

[ 精确质量 ]:
260.080658

[ PSA ]:
92.29000

[ 外观性状 ]:
白色粉末

[ 储存条件 ]:
Store at RT.

[ 稳定性 ]:
Stable. Hygroscopic - protect from moisture. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
H2O: 1 M at 20 °C, clear, colorless

N-2-羟乙基哌嗪-N'-2-乙磺酸钠盐MSDS

详细MSDS(安全技术说明书)

N-2-羟乙基哌嗪-N'-2-乙磺酸钠盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
29335995

N-2-羟乙基哌嗪-N'-2-乙磺酸钠盐上下游产品

N-2-羟乙基哌嗪-N'-2-乙磺酸钠盐上游产品

N-2-羟乙基哌嗪-N'-2-乙磺酸钠盐下游产品

N-2-羟乙基哌嗪-N'-2-乙磺酸钠盐海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

N-2-羟乙基哌嗪-N'-2-乙磺酸钠盐文献

[Permeability of pannexin 1 channels to large anions].

Ross. Fiziol. Zh. Im. I. M. Sechenova 98(12) , 1578-86, (2012)

It is widely accepted that ATP secretion in diverse cells involves pannexin 1 (Panx1) that functions as an ATP-permeable channel. We analyzed the permeability of Panx1 channels heterologically express...

Factor VIII organisation on nanodiscs with different lipid composition.

Thromb. Haemost. 113(4) , 741-9, (2015)

Nanodiscs (ND) are lipid bilayer membrane patches held by amphiphilic scaffolding proteins (MSP) of ~10 nm in diameter. Nanodiscs have been developed as lipid nanoplatforms for structural and function...

Environmentally persistent free radical-containing particulate matter competitively inhibits metabolism by cytochrome P450 1A2.

Toxicol. Appl. Pharmacol. 289 , 223-30, (2015)

Combustion processes generate different types of particulate matter (PM) that can have deleterious effects on the pulmonary and cardiovascular systems. Environmentally persistent free radicals (EPFRs)...

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