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N-羟乙基哌嗪

N-羟乙基哌嗪用途

1-(2-羟乙基)哌嗪是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

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N-羟乙基哌嗪名称

[ CAS 号 ]:
103-76-4

[ 中文名 ]:
1-(2-羟乙基)哌嗪

[ 英文名 ]:
N-(2-Hydroxyethyl)piperazine

[中文别名 ]:

N-羟乙基哌嗪

[英文别名 ]:

1-(2-Hydroxyethyl)piperazine
T6M DNTJ D2Q
N-(2-Hydroxyethyl)Piperazine
1-Piperazinethanol
2-Piperazin-1-ylethanol
N-(β-Hydroxyethyl)piperazine
4-(2-hydroxyethyl)-piperazine
EINECS 203-142-3
PIPERAZINE ETHANOL
2-(piperazin-1-yl)ethanol

N-羟乙基哌嗪生物活性

[ 描述 ]:

1-(2-羟乙基)哌嗪是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

[ 相关类别 ]:

研究领域 >> 其他

[体外研究]

1-哌嗪乙醇是一种羟烷基取代的哌嗪,用于制备药物化合物。它还用作制造聚氨酯催化剂、腐蚀抑制剂、表面活性剂、合成纤维、药物的中间体。也用于合成三亚乙基二胺。

N-羟乙基哌嗪物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
245.0±20.0 °C at 760 mmHg

[ 熔点 ]:
-38.5 °C

[ 分子式 ]:
C₆H₁₄N₂O

[ 分子量 ]:
130.19

[ 闪点 ]:
101.9±21.8 °C

[ 精确质量 ]:
130.110611

[ PSA ]:
35.50000

[ LogP ]:
-0.45

[ 外观性状 ]:
透明至淡黄色液体

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.475

[ 储存条件 ]:
存放于惰性气体之中;避免空气

[ 水溶解性 ]:
MISCIBLE

N-羟乙基哌嗪MSDS

N-羟乙基哌嗪毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TL6825000

CHEMICAL NAME :: 1-Piperazineethanol

CAS REGISTRY NUMBER :: 103-76-4

BEILSTEIN REFERENCE NO. :: 0104361

LAST UPDATED :: 199710

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C6-H14-N2-O

MOLECULAR WEIGHT :: 130.22

WISWESSER LINE NOTATION :: T6M DNTJ D2Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 1/6/1970

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,865,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4920 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3350 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Behavioral - muscle contraction or spasticity

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(5),67,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 mL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 1/6/1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 3720 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Behavioral - muscle contraction or spasticity

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(5),67,1980

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N-羟乙基哌嗪安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R38;R41

[ 安全声明 (欧洲) ]:
S26-S36/39-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
TL6825000

[ 海关编码 ]:
2933599090

N-羟乙基哌嗪合成路线

N-羟乙基哌嗪上下游产品

N-羟乙基哌嗪上游产品

N-羟乙基哌嗪下游产品

N-羟乙基哌嗪制备

由六水哌嗪与环氧乙烷反应而得。将六水哌嗪溶解于水，搅拌冷却至15-20℃，通入环氧乙烷。通毕，于30-35℃，搅拌反应2h，加热蒸出原加水量的90%。冷至15℃以下，过滤。滤液进行减压蒸馏，收集145-155℃（5.33kPa）馏分，得N-（2-羟乙基）哌嗪。

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N-羟乙基哌嗪海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

N-羟乙基哌嗪文献

Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cells.

Drug Des. Devel. Ther. 9 , 425-64, (2015)

Ovarian cancer is a leading killer of women, and no cure for advanced ovarian cancer is available. Alisertib (ALS), a selective Aurora kinase A (AURKA) inhibitor, has shown potent anticancer effects, ...

P2X1-initiated p38 signalling enhances thromboxane A2-induced platelet secretion and aggregation.

Thromb. Haemost. 112(1) , 142-50, (2014)

ATP released by activated platelets can serve as a positive feedback machinery to amplify platelet responses by activating P2X1 receptors. It has, however, not been defined how P2X1 activities influen...

Phenotyping of CYP450 in human liver microsomes using the cocktail approach.

Anal. Bioanal. Chem 406(20) , 4875-87, (2014)

The cocktail approach is an advantageous strategy used to monitor the activities of several cytochromes P450 (CYPs) in a single test to increase the throughput of in vitro phenotyping studies. In this...

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N-羟乙基哌嗪

N-羟乙基哌嗪用途

N-羟乙基哌嗪名称

N-羟乙基哌嗪生物活性

N-羟乙基哌嗪物理化学性质

N-羟乙基哌嗪MSDS

详细MSDS(安全技术说明书)

N-羟乙基哌嗪毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

N-羟乙基哌嗪安全信息

N-羟乙基哌嗪合成路线

详细合成路线

N-羟乙基哌嗪上下游产品

N-羟乙基哌嗪上游产品

N-羟乙基哌嗪下游产品

N-羟乙基哌嗪制备

N-羟乙基哌嗪海关

N-羟乙基哌嗪文献

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