甲基膦酸二甲酯
甲基膦酸二甲酯用途
广泛用作聚氨酯泡沫塑料、聚氨酯树脂、环氧树脂等材料的添加型阻燃剂
甲基膦酸二甲酯名称
[ CAS 号 ]:
756-79-6
[ 中文名 ]:
甲基膦酸二甲酯
[ 英文名 ]:
Dimethyl methylphosphonate
[中文别名 ]:
[英文别名 ]:
- MFCD00008349
- Dimethyl methylphosphonate
- EINECS 212-052-3
- Methanephosphonic acid, dimethyl ester
- Phosphonic acid, P-methyl-, dimethyl ester
- [methoxy(methyl)phosphoryl]oxymethane
- DMMP
甲基膦酸二甲酯物理化学性质
[ 密度 ]:
1.145
[ 沸点 ]:
181 ºC
[ 分子式 ]:
C3H9O3P
[ 分子量 ]:
124.076
[ 闪点 ]:
156 ºF
[ 精确质量 ]:
124.028931
[ PSA ]:
45.34000
[ LogP ]:
-0.78
[ 外观性状 ]:
无色液体
[ 蒸汽压 ]:
1.2±0.3 mmHg at 25°C
[ 折射率 ]:
1.413
[ 稳定性 ]:
Stability Combustible. Incompatible with strong oxidizing agents, strong bases. May soften some rubbers or plastics. Hydrolyzes slowly in contact with water.
[ 水溶解性 ]:
>=10 g/100 mL at 21 ºC
甲基膦酸二甲酯MSDS
甲基膦酸二甲酯毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SZ9120000
- CHEMICAL NAME :
- Phosphonic acid, methyl-, dimethyl ester
- CAS REGISTRY NUMBER :
- 756-79-6
- BEILSTEIN REFERENCE NO. :
- 0878263
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 30
- MOLECULAR FORMULA :
- C3-H9-O3-P
- MOLECULAR WEIGHT :
- 124.09
- WISWESSER LINE NOTATION :
- 1OPO&1&O1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 8210 mg/kg
- TOXIC EFFECTS :
- Behavioral - muscle weakness
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1050 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >6810 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 912 mg/kg
- TOXIC EFFECTS :
- Behavioral - muscle weakness Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - chicken
- DOSE/DURATION :
- 3998 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 75 gm/kg/15D-C
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 130 gm/kg/13W-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 150 gm/kg/15D-C
- TOXIC EFFECTS :
- Gastrointestinal - gastritis Gastrointestinal - other changes Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 260 gm/kg/13W-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 515 gm/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 63 gm/kg
- SEX/DURATION :
- male 63 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 126 gm/kg
- SEX/DURATION :
- male 63 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 15750 mg/kg
- SEX/DURATION :
- male 63 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 61250 mg/kg
- SEX/DURATION :
- male 7 week(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 10 gm/kg
- SEX/DURATION :
- male 20 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 33 gm/kg
- SEX/DURATION :
- female 7-14 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 33400 mg/kg
- SEX/DURATION :
- female 6-13 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
- TYPE OF TEST :
- Specific locus test
- TYPE OF TEST :
- Sperm Morphology
- TYPE OF TEST :
- Dominant lethal test
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 11 gm/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 189,15,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1091 No. of Facilities: 35 (estimated) No. of Industries: 2 No. of Occupations: 4 No. of Employees: 204 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1091 No. of Facilities: 53 (estimated) No. of Industries: 5 No. of Occupations: 8 No. of Employees: 2134 (estimated) No. of Female Employees: 763 (estimated)
甲基膦酸二甲酯安全信息
[ 符号 ]:
GHS07, GHS08
[ 信号词 ]:
Danger
[ 危害声明 ]:
H319-H340-H361f
[ 警示性声明 ]:
P201-P305 + P351 + P338-P308 + P313
[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]:
T:Toxic;
[ 风险声明 (欧洲) ]:
R36;R46
[ 安全声明 (欧洲) ]:
S53-S26-S45
[ 危险品运输编码 ]:
2810
[ WGK德国 ]:
2
[ RTECS号 ]:
SZ9120000
甲基膦酸二甲酯合成路线
甲基膦酸二甲酯制备
1. 酯交换法
（1）亚磷酸三苯酯亚磷酸三苯酯的制备 将苯酚融化后，抽入反应釜，搅拌下保持在40℃下滴加三氯化磷，反应生成亚磷酸三苯酯。副产氯化氢进行吸收处理，粗酯经水洗，静置分去水层，进行减压蒸馏，即得到精制亚磷酸三甲苯酯。
（2）亚磷酸三甲酯的制备 亚磷酸三甲苯酯再在碱性催化剂甲醇钠存在下与甲醇进行酯交换反应生成亚磷酸三甲酯。反应产物经分离除去苯酚及残余甲醇后即得精制亚磷酸三甲酯。
（3）甲基膦酸二甲酯的合成 甲基膦酸二甲酯亚磷酸三甲酯经异构反应而制得甲基膦酸二甲酯。
2.三氯化磷、甲醇直接酯化法 以无水甲醇、三氯化磷和液氨为原料，在二甲苯溶剂存在下进行酯化反应，生成亚磷酸三甲酯，反应在0～10℃温度的条件下进行。制得的粗品经水洗除去氯化铵，再经精馏而得精制亚磷酸三甲酯。亚磷酸三甲酯再经异构化反应而制得甲基膦酸二甲酯。甲基膦酸二甲酯文献
Analyst 140(9) , 2995-3002, (2015)
Proton-bound dimers were dissociated to protonated monomers in air at ambient pressure and temperature using electric fields of ultrahigh Field Asymmetric Ion Mobility Spectrometry (ultraFAIMS) with t...
Synthetic (+)-terrein suppresses interleukin-6/soluble interleukin-6 receptor induced-secretion of vascular endothelial growth factor in human gingival fibroblasts.Bioorg. Med. Chem. 22(19) , 5338-44, (2014)
Interleukin (IL)-6 is a proinflammatory cytokine that performs a wide variety of biological functions, including important roles in the progression of chronic inflammatory diseases such as periodontal...
Facility monitoring of chemical warfare agent simulants in air using an automated, field-deployable, miniature mass spectrometer.Rapid Commun. Mass Spectrom. 25(10) , 1437-44, (2011)
Vapors of four chemical warfare agent (CWA) stimulants, 2-chloroethyl ethyl sulfide (CEES), diethyl malonate (DEM), dimethyl methylphosphonate (DMMP), and methyl salicylate (MeS), were detected, ident...
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