松萝酸

松萝酸用途

(+)-Usnic acid 为地衣中的有效成分,可结合 mTOR 的 ATP 结合口袋,抑制 mTORC1/2 的活性。(+)-Usnic acid 可抑制 mTOR 下游效应蛋白 Akt (Ser473),4EBP1 和 S6K 的磷酸化水平,诱导自噬 (autophay),具有抗肿瘤活性。

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松萝酸名称

[ CAS 号 ]:
7562-61-0

[ 中文名 ]:
松萝酸

[ 英文名 ]:
Usnic acid

[中文别名 ]:

[英文别名 ]:

Usnic acid
EINECS 231-456-0
(+)-Usniacin
MFCD00016878
D-Usnic acid

松萝酸生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> PI3K/Akt/mTOR 信号通路 >> mTOR

研究领域 >> 癌症

[ 靶点 ]

mTORC1

mTORC2

[参考文献]

[1]. Ebrahim HY, et al. Usnic Acid Benzylidene Analogues as Potent Mechanistic Target of Rapamycin Inhibitors for the Control of Breast Malignancies. J Nat Prod. 2017 Apr 28;80(4):932-952.

松萝酸物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
638.2±55.0 °C at 760 mmHg

[ 熔点 ]:
201-203 °C(lit.)

[ 分子式 ]:
C₁₈H₁₆O₇

[ 分子量 ]:
344.315

[ 闪点 ]:
236.0±25.0 °C

[ 精确质量 ]:
344.089600

[ PSA ]:
121.13000

[ LogP ]:
2.30

[ 外观性状 ]:
固体;Light orange to Yellow to Green powder to crystal

[ 蒸汽压 ]:
0.0±2.0 mmHg at 25°C

[ 折射率 ]:
1.679

[ 储存条件 ]:
2~8°C

松萝酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HP5295050

CHEMICAL NAME :: 3(9bH)-dibenzofuranone, 2,6-diacetyl-1,7,9-trihydroxy-8,9b-dimethyl-, D-

CAS REGISTRY NUMBER :: 7562-61-0

LAST UPDATED :: 198910

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C18-H16-O7

MOLECULAR WEIGHT :: 344.34

WISWESSER LINE NOTATION :: T B656 EV HO BHJ B1 CQ DV1 JV1 KQ L1 MQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 838 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 31,247,1972 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1500 ug/kg

SEX/DURATION :: female 1 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 176,249,1955

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松萝酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
HP5295050

[ 海关编码 ]:
2917399090

松萝酸海关

[ 海关编码 ]: 2917399090

[ 中文概述 ]:
2917399090 其他芳香多元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 对苯二甲酸请注明4-CBA值, 对苯二甲酸请注明P-TL酸值, 对苯二甲酸请注明色度, 对苯二甲酸请注明水分

[ Summary ]:
2917399090 aromatic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

松萝酸文献

Proton-shuttling lichen compound usnic acid affects mitochondrial and lysosomal function in cancer cells.

PLoS ONE 7 , e51296, (2012)

The lichen compound usnic acid (UA) is a lipophilic weak acid that acts as a proton shuttle and causes loss of mitochondrial inner membrane potential. In the current study we show that UA treatment in...

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松萝酸