2-硝基-7-甲氧基萘并[2,1-B]呋喃

2-硝基-7-甲氧基萘并[2,1-B]呋喃名称

[ CAS 号 ]:
75965-74-1

[ 中文名 ]:
2-硝基-7-甲氧基萘并[2,1-B]呋喃

[ 英文名 ]:
7-METHOXY-2-NITRONAPHTHO(2,1-b)FURAN

[英文别名 ]:

methoxy-7 nitro-2 naphto<2,1-b>furane
2-Nitro-7-methoxynaphtho(2,1-b)furan
7-methoxy-2-nitronaphtho[2,1-b]furan
5-nitrofuran
nitronaphthofuran (R-7000)
nitro-2 methoxy-7 naphto<2,1-b>furanne
R 7000

2-硝基-7-甲氧基萘并[2,1-B]呋喃物理化学性质

[ 密度 ]:
1.379g/cm3

[ 沸点 ]:
420ºC at 760 mmHg

[ 分子式 ]:
C₁₃H₉NO₄

[ 分子量 ]:
243.21500

[ 闪点 ]:
207.8ºC

[ 精确质量 ]:
243.05300

[ PSA ]:
68.19000

[ LogP ]:
4.02600

[ 折射率 ]:
1.69

[ 储存条件 ]:
2-8°C

2-硝基-7-甲氧基萘并[2,1-B]呋喃毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QL0840000

CHEMICAL NAME :: Naphtho(2,1-b)furan, 7-methoxy-2-nitro-

CAS REGISTRY NUMBER :: 75965-74-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C13-H9-N-O4

MOLECULAR WEIGHT :: 243.23

WISWESSER LINE NOTATION :: T B566 EOJ DNW KO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 210 mg/kg/91W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 24 mg/kg/36W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 11967 ug/kg

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20 mg/kg/10W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 360 mg/kg/12W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 mg/kg/5W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: Sperm Morphology

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Bird - chicken Embryo

DOSE/DURATION :: 1 mg/L

REFERENCE :: AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972- Volume(issue)/page/year: 23,328,1983

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2-硝基-7-甲氧基萘并[2,1-B]呋喃文献

Genotoxicity of 2-nitro-7-methoxy-naphtho[2,1-b]furan (R7000): a case study with some considerations on nitrofurantoin and nifuroxazide.

Res. Microbiol. 153(7) , 427-34, (2002)

Two nitrofurans present broad-spectrum antimicrobial properties and some of them are used in human and veterinary medicine. Most of these molecules are mutagens and some of them were reported as carci...

First characterization of the mutagenic specificity of 7-methoxy-2-nitronaphtho[2,1-b]furan (R7000) in Salmonella typhimurium.

Mutat. Res. 248(1) , 85-92, (1991)

In order to investigate the mutational events induced by the very potent genotoxic agent 7-methoxy-2-nitronaphtho[2,1-b]furan (R7000), we evaluated its mutagenic potency in a battery of his- mutants o...

Influence of the uvr-dependent nucleotide excision repair on DNA adducts formation and mutagenic spectrum of a potent genotoxic agent: 7-methoxy-2-nitronaphtho[2,1-b]furan (R7000).

Mutat. Res. 358(1) , 113-22, (1996)

The influence of the uvr-dependent excision repair system on the lethal action, mutagenic specificity, SOS induction and DNA adducts formation of 7-methoxy-2-nitronaphtho[2,1-b]furan (R7000), a potent...

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