1,1,2-三氟三氯乙烷
1,1,2-三氟三氯乙烷用途
用作聚三氟氯乙烯单体，也用作制冷剂、清洗剂、干洗剂、和溶剂等。主要用作冷冻机的制冷剂和空气溶胶用喷雾剂。也用作发泡剂和灭火剂。由于无毒、不燃烧，对金属和聚合物无腐蚀性，故可用作精密仪器的清洗剂。
1,1,2-三氟三氯乙烷名称
[ CAS 号 ]:
76-13-1
[ 中文名 ]:
1,1,2-三氯三氟乙烷(CFC-113)
[ 英文名 ]:
1,1,2-Trichlorotrifluoroethane
[中文别名 ]:
[英文别名 ]:
- 1,1,2-trichloro-1,2,2-trifluoroethane
- EINECS 200-936-1
- MFCD00000782
1,1,2-三氟三氯乙烷物理化学性质
[ 密度 ]:
1.57 g/mL at 25 °C(lit.)
[ 沸点 ]:
47-48 °C(lit.)
[ 熔点 ]:
−35 °C(lit.)
[ 分子式 ]:
C2Cl3F3
[ 分子量 ]:
187.37600
[ 闪点 ]:
195°C
[ 精确质量 ]:
185.90200
[ LogP ]:
2.91890
[ 外观性状 ]:
无色液体带有一种甜的,像醚的气味
[ 蒸汽密度 ]:
6.5 (vs air)
[ 蒸汽压 ]:
5.5 psi ( 20 °C)
[ 折射率 ]:
n20/D 1.358(lit.)
[ 储存条件 ]:
库房通风低温干燥
[ 稳定性 ]:
Stable. Non-flammable. Incompatible with alkali metals, chemically active metals, magnesium, zinc, aluminium.
[ 水溶解性 ]:
0.02 g/100 mL. Slightly soluble
1,1,2-三氟三氯乙烷MSDS
1,1,2-三氟三氯乙烷毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KJ4000000
- CHEMICAL NAME :
- Ethane, 1,1,2-trichloro-1,2,2-trifluoro-
- CAS REGISTRY NUMBER :
- 76-13-1
- BEILSTEIN REFERENCE NO. :
- 1740335
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 50
- MOLECULAR FORMULA :
- C2-Cl3-F3
- MOLECULAR WEIGHT :
- 187.37
- WISWESSER LINE NOTATION :
- GXGFXGFF
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Open irritation test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 7/10/1970
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,137,1986 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 43 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Skin and Appendages - hair
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 7,378,1964
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 38500 ppm/4H
- TOXIC EFFECTS :
- Behavioral - general anesthetic Behavioral - excitement Behavioral - ataxia
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0520341
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 260 gm/m3/2H
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis
- REFERENCE :
- TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. (Leningrad, Russia) V.1-145, 1949-82. Discontinued. Volume(issue)/page/year: 75,241,1963
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 9 gm/kg
- TOXIC EFFECTS :
- Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - altered sleep time (including change in righting reflex) Skin and Appendages - dermatitis, other (after systemic exposure)
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0520355
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 40 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4164653
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 17 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 29,521,1968
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 59500 ppm/2H
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0520343
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >11 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 29,521,1968
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0520705
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- >12 pph/2H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.7- 1946- Volume(issue)/page/year: 29,381,1968 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 20 pph/6H/2Y-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 11,68,1988
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2000 ppm/6H/2W-I
- REFERENCE :
- TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 18,17,1980 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-STEL 9590 mg/m3 (1250 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 7670 mg/m3 (1000 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 18,365,1974 TOXICOLOGY REVIEW AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 29,521,1968 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 1000 ppm (7600 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,267,1971 OSHA PEL (Gen Indu):8H TWA 1000 ppm (7600 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 1000 ppm (7600 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 1000 ppm (7600 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 1000 ppm (7600 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 1000 ppm (7600 mg/m3);STEL 1250 ppm JAN 1993 OEL-BELGIUM:TWA 1000 ppm (7670 mg/m3);STEL 1250 ppm JAN 1993 OEL-DENMARK:TWA 500 ppm (3800 mg/m3) JAN 1993 OEL-FINLAND:TWA 1000 ppm (7600 mg/m3);STEL 1250 ppm JAN 1993 OEL-FRANCE:TWA 1000 ppm (7600 mg/m3);STEL 1250 ppm JAN 1993 OEL-GERMANY:TWA 500 ppm (3800 mg/m3) JAN 1993 OEL-HUNGARY:STEL 40 mg/m3 JAN 1993 OEL-JAPAN:TWA 500 ppm (380 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 1000 ppm (7600 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 1000 ppm (7600 mg/m3) JAN 1993 OEL-RUSSIA:TWA 500 ppm;STEL 5000 mg/m3 JAN 1993 OEL-SWEDEN:TWA 500 ppm (4000 mg/m3);STEL 750 ppm (6000 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 500 ppm (3800 mg/m3) JAN 1993 OEL-TURKEY:TWA 1000 ppm (7600 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 1000 ppm (7600 mg/m3);STEL 1250 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO THE CHEMICAL-air:10H TWA 1000 ppm;STEL 1250 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 74010 No. of Facilities: 19387 (estimated) No. of Industries: 175 No. of Occupations: 103 No. of Employees: 282795 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 74010 No. of Facilities: 12471 (estimated) No. of Industries: 119 No. of Occupations: 103 No. of Employees: 250773 (estimated) No. of Female Employees: 79790 (estimated)
1,1,2-三氟三氯乙烷安全信息
[ 符号 ]:
GHS06, GHS08
[ 信号词 ]:
Danger
[ 危害声明 ]:
H301 + H311 + H331-H370-H420
[ 警示性声明 ]:
P260-P280-P301 + P310-P311
[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]:
N:Dangerousfortheenvironment;
[ 风险声明 (欧洲) ]:
R52/53;R59
[ 安全声明 (欧洲) ]:
S59-S61-S45-S36/37
[ 危险品运输编码 ]:
UN 3082 9/PG 3
[ WGK德国 ]:
2
[ RTECS号 ]:
KJ4000000
1,1,2-三氟三氯乙烷合成路线
1,1,2-三氟三氯乙烷上下游产品
1,1,2-三氟三氯乙烷上游产品
1,1,2-三氟三氯乙烷下游产品
1,1,2-三氟三氯乙烷制备
由六氯乙烷或四氯乙烯在五氯化锑催化下与氟化氢反应而得。
１．六氯乙烷法 六氯乙烷与氟化氢在催化剂五氯化锑存在下进行反应，反应产
物经碱洗、水洗、分馏、提纯，得成品。
主反应
副反应
２．四氯乙烯法 其反应式如下：
此法是六氯乙烷法生产基础上的改进。工艺简化，产率高，改善了劳动保护条件。
1,1,2-三氟三氯乙烷文献
PLoS ONE 9(4) , e95197, (2014)
Replication of many RNA viruses benefits from subversion of the autophagic pathway through many different mechanisms. Rotavirus, the main etiologic agent of pediatric gastroenteritis worldwide, has be...
Simultaneous determination of CFC-11, CFC-12 and CFC-113 in seawater samples using a purge and trap gas-chromatographic systemTalanta 80(2) , 959-66, (2009)
We have optimized the analytical parameters of a homemade instrument for the simultaneous measurement of the chlorofluorocarbons CCl 2F 2 (CFC-12), CCl 3F (CFC-11) and C 2Cl 3F 3 (CFC-113) in seawater...
Atrial fibrillation and sudden death related to occupational solvent exposure.Am. J. Ind. Med. 25(5) , 731-5, (1994)
Two cases of atrial fibrillation and one case of sudden death occurred in workers exposed to trifluorotrichloroethane (CFC 113) as a solvent/degreasing agent. This agent and related halogenated hydroc...
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相关化合物
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