{2-[4-(2-氯-1,2-二苯基乙烯基)苯氧基]乙基}二乙胺 2-羟基-1,2,3-丙烷三羧酸

用途

Zuclomiphene citrate 是柠檬酸克罗米芬的顺式异构体。Zuclomiphene citrate 具有抗雌激素的作用,比反式异构体更能抑制黄体生成激素 (LH) 的分泌。Zuclomiphene citrate 也是一种口服活性降胆固醇药。

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名称

[ CAS 号 ]:
7619-53-6

[ 中文名 ]:
{2-[4-(2-氯-1,2-二苯基乙烯基)苯氧基]乙基}二乙胺 2-羟基-1,2,3-丙烷三羧酸

[ 英文名 ]:
Zuclomiphene (citrete)

[英文别名 ]:

cis-6,cis-11-Methyl-octadecadienoat
cis-clomiphene citrate
clomphencitrate
cis-cis-6,11-Octadecadiensaeuremethylester
Methyl-cis,cis-octadeca-6,11-dienoat
cis,cis-Octadeca-6,11-diensaeure-methylester
clomifen citrate
I-Dihydrocitrat
zuclomiphene citrate

生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 雌激素受体/ERR

研究领域 >> 内分泌

研究领域 >> 代谢疾病

[ 靶点 ]

Estrogen Receptor/ERR

[参考文献]

[1]. Fontenot GK, et al. Differential effects of isomers of clomiphene citrate on reproductive tissues in male mice. BJU Int. 2016 Feb;117(2):344-50.

[2]. Mikkelson TJ, et al. Single-dose pharmacokinetics of clomiphene citrate in normal volunteers. Fertil Steril. 1986 Sep;46(3):392-6.

[3]. Sutherland RL. Estrogen antagonists in chick oviduct: antagonist activity of eight synthetic triphenylethylene derivatives and their interactions with cytoplasmic and nuclear estrogen receptors. Endocrinology. 1981 Dec;109(6):2061-8.

[4]. Ramsey RB, et al. The biochemical and morphological response of hydrolytic enzymes in the developing brain to hypocholesterolemic agents. Acta Neuropathol. 1980;49(2):89-94.

物理化学性质

[ 分子式 ]:
C₃₂H₃₆ClNO₈

[ 分子量 ]:
598.08300

[ 精确质量 ]:
597.21300

[ PSA ]:
144.60000

[ LogP ]:
5.31410

[ 外观性状 ]:
固体

[ 储存条件 ]:
2-8°C

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YE0930000

CAS REGISTRY NUMBER :: 7619-53-6

LAST UPDATED :: 198910

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C26-H28-Cl-N-O.C6-H8-O7

MOLECULAR WEIGHT :: 598.14

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 30 mg/kg

SEX/DURATION :: male 60 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 11,23,1973