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氯化铯

氯化铯用途

氯化铯是钾通道的阻滞剂。氯化铯可防止四氧嘧啶[1][2]产生的钠离子转运减少。氯化铯已诱发心律失常,包括动物模型中的尖端扭转型室性心动过速[3]。

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氯化铯名称

[ CAS 号 ]:
7647-17-8

[ 中文名 ]:
氯化铯

[ 英文名 ]:
Cesium chloride

[中文别名 ]:

氯化銫,光学级

[英文别名 ]:

EINECS 231-600-2
cesium,chloride
MFCD00010955
Cesium chloride

氯化铯生物活性

[ 描述 ]:

氯化铯是钾通道的阻滞剂。氯化铯可防止四氧嘧啶[1][2]产生的钠离子转运减少。氯化铯已诱发心律失常,包括动物模型中的尖端扭转型室性心动过速[3]。

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 跨膜转运 >> 钾通道

[体外研究]

氯化铯(CsCl)降低丙烯醛诱导的膜电位增加、细胞内钙升高和NOS、ET-1和VEGF表达上调[3]。

[体内研究]

氯化铯(12 mg/100 g体重,每天30天；i.p.；雄性Wistar大鼠-BOO模型)可显著削弱XJT(中药)不仅对这些钾通道的表达,而且对膀胱重量、尿动力学和氧化应激的影响[1]。

[参考文献]

[1]. Sun J, Shen W, et al. A Chinese Medicine Formula "Xian-Jia-Tang" for Treating Bladder Outlet Obstruction by Improving Urodynamics and Inhibiting Oxidative Stress through Potassium Channels. Evid Based Complement Alternat Med. 2017;2017:8147258.

[2]. Soto C, et al. Alloxan decreases intracellular potassium content of the isolated frog skin epithelium. Comp Biochem Physiol C Toxicol Pharmacol. 2001;130(1):19-27.

[3]. Ouyang JS, Li YP, Li CY, et al. Mitochondrial ROS-K+ channel signaling pathway regulated secretion of human pulmonary artery endothelial cells. Free Radic Res. 2012;46(12):1437-1445.

[4]. O'Brien CE, et al. Cesium-induced QT-interval prolongation in an adolescent. Pharmacotherapy. 2008;28(8):1059-1065.

氯化铯物理化学性质

[ 密度 ]:
3.983

[ 沸点 ]:
1290 °C

[ 熔点 ]:
645 °C(lit.)

[ 分子式 ]:
CsCl

[ 分子量 ]:
168.359

[ 闪点 ]:
1303°C

[ 精确质量 ]:
167.874298

[ 外观性状 ]:
白色/透明结晶粉末

[ 折射率 ]:
1.6418

[ 储存条件 ]:
库房低温通风干燥

[ 稳定性 ]:
Stable. Deliquescent. Incompatible with strong oxidizing agents, strong acids. Protect from moisture.

[ 水溶解性 ]:
1860 g/L (20 ºC)

氯化铯MSDS

详细MSDS(安全技术说明书)

氯化铯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FK9625000

CHEMICAL NAME :: Cesium chloride

CAS REGISTRY NUMBER :: 7647-17-8

LAST UPDATED :: 199701

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: Cl-Cs

MOLECULAR WEIGHT :: 168.36

WISWESSER LINE NOTATION :: CS G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2306 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1460 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 910 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 706 mg/kg

SEX/DURATION :: female 1-21 day(s) pre-mating lactating female 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - biochemical and metabolic Reproductive - Effects on Newborn - physical

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 262 gm/kg

SEX/DURATION :: female 1-21 day(s) after conception lactating female 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - biochemical and metabolic Reproductive - Effects on Newborn - physical

TYPE OF TEST :: Mutation test systems - not otherwise specified

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 125 mg/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 244,295,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3874 No. of Facilities: 189 (estimated) No. of Industries: 3 No. of Occupations: 6 No. of Employees: 3353 (estimated) No. of Female Employees: 1792 (estimated)

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氯化铯安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H361

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R68

[ 安全声明 (欧洲) ]:
S36/37-S26

[ 危险品运输编码 ]:
2923

[ WGK德国 ]:
2

[ RTECS号 ]:
FK9625000

[ 海关编码 ]:
28273980

氯化铯制备

1.将碳酸铯溶解于少量水中。在不断搅拌下慢慢加入相对密度为1.18的盐酸，加热反应:

当pH=3时，煮沸半小时加入氢氧化铯使溶液pH值到中性。过滤，滤液蒸发浓缩至大量结晶析出，冷至室温，分离母液，洁净与100ºC烘干，即为成品。

2.用碳酸铯溶于盐酸，再浓缩其溶液以制取氯化铯。通常可得到纯度为99.5%的氯化铯，可直接使用。对不够纯净的氯化铯，可采用下列方法精制。将15g的氯化铯，加热溶于100mL的水中。将化学计量24.2g氯化汞溶于25mL 4mol的盐酸中。趁热将此HgCl2HCl溶液加到上述溶液中，搅拌混合，冷却，即可析出CsHgCl3结晶。吸滤，收集结晶，弃去母液。将结晶溶于120mL的热水中，冷却后再次有结晶析出。为此反复进行2～3次重结晶，碱金属可降至0.01%以下，最后将结晶溶于热水，通入H2S气体使溶液达到饱和，就有HgS沉淀析出，滤去HgS,收集滤液，蒸发至干，即可得纯净的氯化铯。

3.通常可得到纯度为995%的氯化铯，可直接使用。对不够纯净的氯化铯，可采用下列方法精制。

精制方法1［166］将15g的氯化铯，加热溶于100mL的水中。将化学计量24.2g氯化汞溶于25mL 4mol的盐酸中。趁热将此HgCl2、HCl溶液加到上述溶液中，搅拌混合，冷却，即可析出CsHgCl3结晶。吸滤，收集结晶，弃去母液。将结晶溶于120mL的热水中，冷却后再次有结晶析出。为此反复进行2～3次重结晶，碱金属可降至0.01%以下，最后将结晶溶于热水，通入H2S气体使溶液达到饱和，就有HgS沉淀析出，滤去HgS,收集滤液，蒸发至干，即可得纯净的氯化铯。

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氯化铯海关

[ 海关编码 ]: 28273980

氯化铯文献

Adenoviral-mediated gene transfer of insulin-like growth factor 1 enhances wound healing and induces angiogenesis.

J. Surg. Res. 190(1) , 367-77, (2014)

Chronic wounds are characterized by a wound healing and neovascularization deficit. Strategies to increase neovascularization can significantly improve chronic wound healing. Insulin-like growth facto...

Analysis of triacetone triperoxide complexes with alkali metal ions by electrospray and extractive electrospray ionisation combined with ion mobility spectrometry and mass spectrometry.

Eur. J. Mass Spectrom. (Chichester, Eng.) 21 , 265-74, (2015)

The complexation of triacetone triperoxide (TATP) with a range of alkali metals has been studied by electrospray ionisation-mass spectrometry yield [M+Cat](+) ions for all of the alkali metals. The fo...

Coat Protein-Dependent Behavior of Poly(ethylene glycol) Tails in Iron Oxide Core Virus-like Nanoparticles.

ACS Appl. Mater. Interfaces 7 , 12089-98, (2015)

Here we explore the formation of virus-like nanoparticles (VNPs) utilizing 22-24 nm iron oxide nanoparticles (NPs) as cores and proteins derived from viral capsids of brome mosaic virus (BMV) or hepat...

更多文献

氯化铯

氯化铯用途

氯化铯名称

氯化铯生物活性

氯化铯物理化学性质

氯化铯MSDS

详细MSDS(安全技术说明书)

氯化铯毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

氯化铯安全信息

氯化铯制备

氯化铯海关

氯化铯文献

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