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8-溴腺苷-3',5'-环单磷酸钠

8-溴腺苷-3',5'-环单磷酸钠用途

8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt) 是一种环 AMP 类似物,是一种环 AMP 依赖性蛋白激酶 (PKA) 激活剂。

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8-溴腺苷-3',5'-环单磷酸钠名称

[ CAS 号 ]:
76939-46-3

[ 中文名 ]:
8-溴腺苷-3,5-环单磷酸钠

[ 英文名 ]:
8-Bromo-cAMP sodium salt

[中文别名 ]:

8-溴腺苷-3',5'-环单磷酸钠

[英文别名 ]:

8-BROMOADENOSINE 3':5'-CYCLICMONOPHOSPHA TE SODIUM
CAMP,8-BR,NA
8-BROMOADENOSINE-3',5'-CYCLOPHOSPHATE SODIUM SALT
8-BR-CAMP NA
8-BROMO-CAMP,NA
8-bromoadenosine 3:5-cyclic*monophosphate sodiu
8-BROMO-CAMP,SODIUM SALT
8-BR-CAMP SODIUM SALT
8-Bromoadenosine 3',5'-phosphoric acid sodium salt
MFCD00005844

8-溴腺苷-3',5'-环单磷酸钠生物活性

[ 描述 ]:

8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt) 是一种环 AMP 类似物,是一种环 AMP 依赖性蛋白激酶 (PKA) 激活剂。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 蛋白酪氨酸激酶 >> PKA

信号通路 >> 干细胞及 Wnt 通路 >> PKA

[ 靶点 ]

PKA[1]

[体外研究]

8-溴-cAMP钠盐是环状AMP的溴化衍生物。 8-Bromo-cAMP钠盐可提高细胞重编程的效率。 8-Bromo-cAMP钠盐改善人新生儿包皮成纤维细胞(HFF1)细胞的重编程效率。 8-Bromo-cAMP钠盐抑制恶性胶质瘤细胞系(A-172)和食管癌细胞系(Eca-109)的增殖,诱导分化和凋亡[1]。

[参考文献]

[1]. Wang Y, et al. A cyclic AMP analog, 8-Br-cAMP, enhances the induction of pluripotency in human fibroblast cells. Stem Cell Rev. 2011 Jun;7(2):331-41.

8-溴腺苷-3',5'-环单磷酸钠物理化学性质

[ 分子式 ]:
C₁₀H₁₀BrN₅NaO₆P

[ 分子量 ]:
430.08

[ 精确质量 ]:
428.944977

[ PSA ]:
167.48000

[ LogP ]:
0.96450

[ 外观性状 ]:
灰白色粉末

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
H2O: 100 mg/mL

8-溴腺苷-3',5'-环单磷酸钠安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

8-溴腺苷-3',5'-环单磷酸钠文献

ADAM12-directed ectodomain shedding of E-cadherin potentiates trophoblast fusion.

Cell Death Differ. 22 , 1970-84, (2015)

Trophoblasts, placental cells of epithelial lineage, undergo extensive differentiation to form the cellular components of the placenta. Trophoblast progenitor cell differentiation into the multinuclea...

Immunomodulatory effects of Lippia sidoides extract: induction of IL-10 through cAMP and p38 MAPK-dependent mechanisms.

J. Med. Food 18(3) , 370-7, (2015)

Lippia sidoides is an aromatic shrub that grows wild in the northeastern region of Brazil. In local traditional medicine, the aerial portions of this species are used as anti-infectives, antiseptics, ...

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

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