柠檬酸三乙酯(TEC)
柠檬酸三乙酯(TEC)用途
柠檬酸三乙酯(TEC)名称
[ CAS 号 ]:
77-93-0
[ 中文名 ]:
柠檬酸三乙酯
[ 英文名 ]:
Triethyl citrate
[中文别名 ]:
[英文别名 ]:
- triethyl 2-hydroxypropane-1,2,3-tricarboxylate
- EINECS 201-070-7
- MFCD00009201
柠檬酸三乙酯(TEC)生物活性
[ 描述 ]:
[ 相关类别 ]:
[参考文献]
柠檬酸三乙酯(TEC)物理化学性质
[ 密度 ]:
1.2±0.1 g/cm3
[ 沸点 ]:
294.0±0.0 °C at 760 mmHg
[ 熔点 ]:
-46 °C
[ 分子式 ]:
C12H20O7
[ 分子量 ]:
276.283
[ 闪点 ]:
95.4±11.7 °C
[ 精确质量 ]:
276.120911
[ PSA ]:
99.13000
[ LogP ]:
1.49
[ 外观性状 ]:
油性无色液体
[ 蒸汽密度 ]:
9.7 (vs air)
[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C
[ 折射率 ]:
1.462
[ 储存条件 ]:
-20°C
[ 水溶解性 ]:
5.7 g/100 mL (25 ºC)
[ 凝固点 ]:
-55℃
柠檬酸三乙酯(TEC)MSDS
柠檬酸三乙酯(TEC)毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GE8050000
- CHEMICAL NAME :
- Citric acid, triethyl ester
- CAS REGISTRY NUMBER :
- 77-93-0
- BEILSTEIN REFERENCE NO. :
- 1801199
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 12
- MOLECULAR FORMULA :
- C12-H20-O7
- MOLECULAR WEIGHT :
- 276.32
- WISWESSER LINE NOTATION :
- 2OV1XQVO2&1VO2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5900 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 16,214,1985
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1300 ppm/6H
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - pleural effusion Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- 14CYAT "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New York, John Wiley & Sons, Inc., 1958-63 Volume(issue)/page/year: 2,1892,1963
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4 gm/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 16,214,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 6600 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 16,214,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1750 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Vascular - other changes
- REFERENCE :
- JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 53,774,1964
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 3500 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Gastrointestinal - nausea or vomiting
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,389,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,389,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- >25 mL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2703360 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4900 mg/kg/14D-I
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 53,774,1964
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 15904 mg/kg/8W-C
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Behavioral - ataxia
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,283,1959 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7556 No. of Facilities: 358 (estimated) No. of Industries: 9 No. of Occupations: 20 No. of Employees: 11496 (estimated) No. of Female Employees: 3993 (estimated)
柠檬酸三乙酯(TEC)安全信息
[ 个人防护装备 ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)
[ 危害码 (欧洲) ]:
Xn
[ 风险声明 (欧洲) ]:
20
[ 安全声明 (欧洲) ]:
S24/25
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
1
[ RTECS号 ]:
GE8050000
[ 海关编码 ]:
2918150000
柠檬酸三乙酯(TEC)合成路线
柠檬酸三乙酯(TEC)上下游产品
柠檬酸三乙酯(TEC)上游产品
柠檬酸三乙酯(TEC)下游产品
柠檬酸三乙酯(TEC)制备
由柠檬酸和乙醇直接酯化,再经中和,水洗,脱醇等精制过程制得。
柠檬酸三乙酯(TEC)海关
[ 海关编码 ]: 2918150000
[ 中文概述 ]:
2918150000. 柠檬酸盐和柠檬酸酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:4ABxy(出口许可证,入境货物通关单,出境货物通关单出口许可证(加工贸易),出口许可证(边境小额贸易)). 最惠国关税:6.5%. 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ 监管条件 ]: 4.出口许可证 A.入境货物通关单 B.出境货物通关单 x.出口许可证(加工贸易) y.出口许可证(边境小额贸易)
[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 N.出口商品检验
[ Summary ]:
2918150000. other salts and esters of citric acid. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:4ABXY(export license,certificate of inspection for goods inward,certificate of inspection for goods outwardexport license(processing trade),export license(border small volume trade)). MFN tariff:6.5%. General tariff:30.0%
柠檬酸三乙酯(TEC)文献
Int. J. Pharm. 477(1-2) , 631-42, (2014)
Naltrexone hydrochloride (NTX) is an innovative drug used in ophthalmology for treatment of ocular surface diseases such as impaired corneal wound healing and severe dry eye. Poor chemical stability h...
Formulation considerations in the design of topical, polymeric film-forming systems for sustained drug delivery to the skin.Eur. J. Pharm. Biopharm. 91 , 9-15, (2015)
Polymeric film-forming systems (FFSs) are potential drug delivery systems for topical application to the skin. The FFSs form thin and transparent polymeric films in situ upon solvent evaporation. Thei...
Controlled release of acidic drugs in compendial and physiological hydrogen carbonate buffer from polymer blend-coated oral solid dosage forms.Eur. J. Pharm. Sci. 77 , 246-53, (2015)
The objective of this study was to investigate the suitability of "Eudragit® RL/Eudragit® L55" (RL/L55) blend coatings for a pH-independent release of acidic drugs. A coating for ketoprofen and naprox...
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¥168.0/500ml
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区域:上海市浦东新区
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¥需询单/1g
联系人:赖经理
产品详情:Triethyl citrate
公司名:上海阿拉丁生化科技股份有限公司
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价格:
¥205.9/1ml
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