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柠檬酸三乙酯(TEC)

柠檬酸三乙酯(TEC)用途

Triethyl citrate 是柠檬酸的一个酯。 Triethyl citrate 可用作纤维素塑料基纳米复合材料的增塑剂。
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柠檬酸三乙酯(TEC)名称

[ CAS 号 ]:
77-93-0

[ 中文名 ]:
柠檬酸三乙酯

[ 英文名 ]:
Triethyl citrate

[中文别名 ]:

[英文别名 ]:

柠檬酸三乙酯(TEC)生物活性

[ 描述 ]:

Triethyl citrate 是柠檬酸的一个酯。 Triethyl citrate 可用作纤维素塑料基纳米复合材料的增塑剂。

[ 相关类别 ]:

研究领域 >> 其他
信号通路 >> 其他 >> 其他

[参考文献]

[1]. Hwan-Man Park; Manjusri Misra; Lawrence T. Drzal & Amar K. Mohanty (2004). ""Green" Nanocomposites from Cellulose Acetate Bioplastic and Clay: Effect of Eco-Friendly Triethyl Citrate Plasticizer". Biomacromolecules. 5 (6): 2281–2288. 

柠檬酸三乙酯(TEC)物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
294.0±0.0 °C at 760 mmHg

[ 熔点 ]:
-46 °C

[ 分子式 ]:
C12H20O7

[ 分子量 ]:
276.283

[ 闪点 ]:
95.4±11.7 °C

[ 精确质量 ]:
276.120911

[ PSA ]:
99.13000

[ LogP ]:
1.49

[ 外观性状 ]:
油性无色液体

[ 蒸汽密度 ]:
9.7 (vs air)

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.462

[ 储存条件 ]:
-20°C

[ 水溶解性 ]:
5.7 g/100 mL (25 ºC)

[ 凝固点 ]:
-55℃

柠檬酸三乙酯(TEC)MSDS

详细MSDS(安全技术说明书)

柠檬酸三乙酯(TEC)毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GE8050000
CHEMICAL NAME :
Citric acid, triethyl ester
CAS REGISTRY NUMBER :
77-93-0
BEILSTEIN REFERENCE NO. :
1801199
LAST UPDATED :
199701
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C12-H20-O7
MOLECULAR WEIGHT :
276.32
WISWESSER LINE NOTATION :
2OV1XQVO2&1VO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5900 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 16,214,1985
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1300 ppm/6H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - pleural effusion Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
14CYAT "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New York, John Wiley & Sons, Inc., 1958-63 Volume(issue)/page/year: 2,1892,1963
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4 gm/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 16,214,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6600 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 16,214,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1750 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Vascular - other changes
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 53,774,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
3500 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Gastrointestinal - nausea or vomiting
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,389,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,389,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
>25 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2703360 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4900 mg/kg/14D-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 53,774,1964
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
15904 mg/kg/8W-C
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Behavioral - ataxia
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,283,1959 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7556 No. of Facilities: 358 (estimated) No. of Industries: 9 No. of Occupations: 20 No. of Employees: 11496 (estimated) No. of Female Employees: 3993 (estimated)
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柠檬酸三乙酯(TEC)安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
20

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
GE8050000

[ 海关编码 ]:
2918150000

柠檬酸三乙酯(TEC)合成路线

详细合成路线

柠檬酸三乙酯(TEC)上下游产品

柠檬酸三乙酯(TEC)上游产品

柠檬酸三乙酯(TEC)下游产品

柠檬酸三乙酯(TEC)制备

由柠檬酸和乙醇直接酯化，再经中和，水洗，脱醇等精制过程制得。
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柠檬酸三乙酯(TEC)海关

[ 海关编码 ]: 2918150000

[ 中文概述 ]:
2918150000. 柠檬酸盐和柠檬酸酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:4ABxy(出口许可证,入境货物通关单,出境货物通关单出口许可证(加工贸易),出口许可证(边境小额贸易)). 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: 4.出口许可证 A.入境货物通关单 B.出境货物通关单 x.出口许可证(加工贸易) y.出口许可证(边境小额贸易)

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 N.出口商品检验

[ Summary ]:
2918150000. other salts and esters of citric acid. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:4ABXY(export license,certificate of inspection for goods inward,certificate of inspection for goods outwardexport license(processing trade),export license(border small volume trade)). MFN tariff:6.5%. General tariff:30.0%

柠檬酸三乙酯(TEC)文献

Novel in situ gelling ocular films for the opioid growth factor-receptor antagonist-naltrexone hydrochloride: fabrication, mechanical properties, mucoadhesion, tolerability and stability studies.

Int. J. Pharm. 477(1-2) , 631-42, (2014)

Naltrexone hydrochloride (NTX) is an innovative drug used in ophthalmology for treatment of ocular surface diseases such as impaired corneal wound healing and severe dry eye. Poor chemical stability h...

Formulation considerations in the design of topical, polymeric film-forming systems for sustained drug delivery to the skin.

Eur. J. Pharm. Biopharm. 91 , 9-15, (2015)

Polymeric film-forming systems (FFSs) are potential drug delivery systems for topical application to the skin. The FFSs form thin and transparent polymeric films in situ upon solvent evaporation. Thei...

Controlled release of acidic drugs in compendial and physiological hydrogen carbonate buffer from polymer blend-coated oral solid dosage forms.

Eur. J. Pharm. Sci. 77 , 246-53, (2015)

The objective of this study was to investigate the suitability of "Eudragit® RL/Eudragit® L55" (RL/L55) blend coatings for a pH-independent release of acidic drugs. A coating for ketoprofen and naprox...


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