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2-氨基-3,4-二甲基-3H-咪唑并喹啉

2-氨基-3,4-二甲基-3H-咪唑并喹啉用途

Me IQ(甲基IQ)是一种口服活性杂环胺,具有致癌和致突变作用。Me IQ在肝脏中的致突变性是未诱导小鼠和兔子的肺微粒体制剂的几百倍[1][2]。

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2-氨基-3,4-二甲基-3H-咪唑并喹啉名称

[ CAS 号 ]:
77094-11-2

[ 中文名 ]:
2-氨基-3,4-二甲基-3H-咪唑并喹啉

[ 英文名 ]:
MeIQ

[中文别名 ]:

[英文别名 ]:

Methyl IQ
Me IQ
3,4-dimethyl-3H-imidazo<quinolin-2-amine
MelQ
2-amino-3,4-dimethylimidazo<4,5-f>quinoline

2-氨基-3,4-二甲基-3H-咪唑并喹啉生物活性

[ 描述 ]:

Me IQ(甲基IQ)是一种口服活性杂环胺,具有致癌和致突变作用。Me IQ在肝脏中的致突变性是未诱导小鼠和兔子的肺微粒体制剂的几百倍[1][2]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[体外研究]

Me IQ(甲基IQ；含0.04%或0.01%的饮食) 导致小鼠前胃鳞状细胞癌和乳头状瘤的发生率很高。0.04%剂量组的我的智商诱发的前胃鳞状细胞癌中约40%转移至肝脏[1]。

[参考文献]

[1]. H Ohgaki, et al. Carcinogenicities in mice and rats of IQ, MeIQ, and MeIQx. Princess Takamatsu Symp. 1985;16:97-105.

[2]. T Aune, et al. Mutagenic activation of IQ and Me-IQ by liver and lung microsomes from rabbit and mouse, and with isolated lung cells from the rabbit. Carcinogenesis. 1986 Feb;7(2):273-6.

2-氨基-3,4-二甲基-3H-咪唑并喹啉物理化学性质

[ 密度 ]:
1.36g/cm3

[ 沸点 ]:
465.7ºC at 760 mmHg

[ 熔点 ]:
291-293ºC

[ 分子式 ]:
C₁₂H₁₂N₄

[ 分子量 ]:
212.25000

[ 闪点 ]:
235.4ºC

[ 精确质量 ]:
212.10600

[ PSA ]:
56.73000

[ LogP ]:
2.59330

[ 折射率 ]:
1.725

[ 储存条件 ]:
库房通风低温干燥

2-氨基-3,4-二甲基-3H-咪唑并喹啉毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NJ5907000

CHEMICAL NAME :: 3H-Imidazo(4,5-f)quinoline, 2-amino-3,4-dimethyl-

CAS REGISTRY NUMBER :: 77094-11-2

LAST UPDATED :: 199807

DATA ITEMS CITED :: 30

MOLECULAR FORMULA :: C12-H12-N4

MOLECULAR WEIGHT :: 212.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5040 mg/kg/40W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors Endocrine - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7476 mg/kg/89W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 22120 mg/kg/81W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 27888 mg/kg/83W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Morphological transformation

TYPE OF TEST :: DNA damage

TYPE OF TEST :: DNA damage

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - guinea pig Lung

DOSE/DURATION :: 10 umol/L

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 7,245,1985 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,197,1993 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,275,1986 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,275,1986 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,197,1993 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,197,1993

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2-氨基-3,4-二甲基-3H-咪唑并喹啉安全信息

[ 危害码 (欧洲) ]:
T: Toxic;

[ 海关编码 ]:
2933990090

2-氨基-3,4-二甲基-3H-咪唑并喹啉合成路线

详细合成路线

2-氨基-3,4-二甲基-3H-咪唑并喹啉海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%