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吲哚-3-乙腈

吲哚-3-乙腈用途

3-Indoleacetonitrile 是一种内源性代谢产物。

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吲哚-3-乙腈名称

[ CAS 号 ]:
771-51-7

[ 中文名 ]:
吲哚-3-乙腈

[ 英文名 ]:
3-Indoleacetonitrile

[中文别名 ]:

[英文别名 ]:

Indole-3-acetonitrile
3-Indolacetonitrile
(3-Indolyl)acetonitrile
(indol-3-yl)acetonitrile
3-cyanomethyl-1H-indole
Indolylacetonitrile
MFCD00005628
3-Indolylacetonitrile
Indolylacetonitril
Indole-3-acetonitrile (8CI)

吲哚-3-乙腈生物活性

[ 描述 ]:

3-Indoleacetonitrile 是一种内源性代谢产物。

[ 相关类别 ]:

研究领域 >> 代谢疾病

吲哚-3-乙腈物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
374.1±17.0 °C at 760 mmHg

[ 熔点 ]:
33-36 °C(lit.)

[ 分子式 ]:
C₁₀H₈N₂

[ 分子量 ]:
156.184

[ 闪点 ]:
127.6±6.1 °C

[ 精确质量 ]:
156.068741

[ PSA ]:
39.58000

[ LogP ]:
1.37

[ 外观性状 ]:
灰白色晶体

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.673

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
可溶于：甲醇

吲哚-3-乙腈MSDS

吲哚-3-乙腈毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AM0700000

CHEMICAL NAME :: Acetonitrile, 3-indolyl-

CAS REGISTRY NUMBER :: 771-51-7

BEILSTEIN REFERENCE NO. :: 0125488

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H8-N2

MOLECULAR WEIGHT :: 156.20

WISWESSER LINE NOTATION :: T56 BMJ D1CN

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 255 mg/kg

TOXIC EFFECTS :: Behavioral - coma

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 18,159,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

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吲哚-3-乙腈安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302 + H312 + H332

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S36/37

[ 危险品运输编码 ]:
3276

[ WGK德国 ]:
3

[ RTECS号 ]:
AM0700000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29339990

吲哚-3-乙腈合成路线

吲哚-3-乙腈上下游产品

吲哚-3-乙腈上游产品

吲哚-3-乙腈下游产品

吲哚-3-乙腈海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

吲哚-3-乙腈文献

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J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 988 , 53-8, (2015)

Indole-3-acetic acid (IAA) is produced from tryptophan through five synthesis pathways. A comprehensive method for the quantification of IAA and biosynthesis-related intermediates in a culture medium ...

The extended version of restriction analysis approach for the examination of the ability of low-molecular-weight compounds to modify DNA in a cell-free system.

Food Chem. Toxicol. 75 , 118-27, (2015)

One of the primary requirements in toxicology is the assessment of ability of chemicals to induce DNA covalent modification. There are several well-established methods used for this purpose such as (3...

Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators.

J. Med. Chem. 54 , 5320, (2011)

Tryptophan catabolism mediated by indoleamine 2,3-dioxygenase (IDO) is an important mechanism of peripheral immune tolerance contributing to tumoral immune resistance. IDO inhibition is thus an active...

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