1,1,2-三氯乙烷
1,1,2-三氯乙烷用途
主要用作脂肪、树脂、蜡、生物碱的溶剂，橡胶和树脂的中间体，农药杀虫剂，制备1,1-二氯乙烯等化学品
【用途二】
用于有机合成，也用作醋酸纤维和橡胶的溶剂
【用途三】
用作脂肪、油、蜡和树脂的溶剂，染料、香料的萃取剂，树脂和橡胶等的中间体，农业上的杀虫剂、熏蒸剂以及合成1,1-二氯乙烯的原料。用于生产偏二氯乙烯。
【用途四】
脂肪、油脂、树脂、生物碱等溶剂，有机合成。
【用途五】
脂肪、油脂、树脂、生物碱等溶剂，有机合成。校准仪器和装置；评价方法；工作标准；质量保证/质量控制；其他。
1,1,2-三氯乙烷名称
[ CAS 号 ]:
79-00-5
[ 中文名 ]:
1,1,2-三氯乙烷
[ 英文名 ]:
1,1,2-Trichloroethane solution
[中文别名 ]:
[英文别名 ]:
- Ethane, trichloro-
- EINECS 201-166-9
- MFCD00000852
- 1,1,2-Trichloroethane
1,1,2-三氯乙烷物理化学性质
[ 密度 ]:
1.435
[ 沸点 ]:
110-115ºC
[ 熔点 ]:
-37ºC
[ 分子式 ]:
C2H3Cl3
[ 分子量 ]:
133.40400
[ 闪点 ]:
11ºC
[ 精确质量 ]:
131.93000
[ LogP ]:
2.02890
[ 外观性状 ]:
无色液体带有一种温和氯气味
[ 折射率 ]:
1.47-1.472
[ 储存条件 ]:
库房通风低温干燥,与食品添加剂分开存放
[ 稳定性 ]:
Stable.
[ 水溶解性 ]:
4 g/L (20 ºC)
1,1,2-三氯乙烷MSDS
1,1,2-三氯乙烷毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KJ3150000
- CHEMICAL NAME :
- Ethane, 1,1,2-trichloro-
- CAS REGISTRY NUMBER :
- 79-00-5
- BEILSTEIN REFERENCE NO. :
- 1731726
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 76
- MOLECULAR FORMULA :
- C2-H3-Cl3
- MOLECULAR WEIGHT :
- 133.40
- WISWESSER LINE NOTATION :
- GYG1G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Open irritation test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - guinea pig
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 836 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 ppm/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 265 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 378 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes Gastrointestinal - ulceration or bleeding from stomach
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 494 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 227 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Behavioral - sleep Liver - hepatitis (hepatocellular necrosis), zonal
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 450 mg/kg
- TOXIC EFFECTS :
- Liver - liver function tests impaired
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 95 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 13100 mg/m3/4.5H
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - general anesthetic Gastrointestinal - changes in structure or function of salivary glands
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 3730 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 970 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 970 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 532 mg/kg/14D-I
- TOXIC EFFECTS :
- Brain and Coverings - changes in brain weight Endocrine - changes in thymus weight Related to Chronic Data - changes in testicular weight
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 27 gm/kg/90D-C
- TOXIC EFFECTS :
- Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 76 gm/kg/78W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Endocrine - adrenal cortex tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 152 gm/kg/78W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Endocrine - adrenal cortex tumors
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TYPE OF TEST :
- Cytogenetic analysis
MUTATION DATA
- TYPE OF TEST :
- DNA adduct
- TEST SYSTEM :
- Mammal - species unspecified Lymphocyte
- REFERENCE :
- TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 11,243,1982 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 55 mg/m3 (10 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 20,533,1979 IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,337,1991 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 20,533,1979 IARC Cancer Review:Human No Available Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,337,1991 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,337,1991 TOXICOLOGY REVIEW FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 18,365,1974 TOXICOLOGY REVIEW AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 40(3),A46,1979 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 10 ppm (45 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,263,1971 OSHA PEL (Gen Indu):8H TWA 10 ppm (45 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 10 ppm (45 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 10 ppm (45 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 10 ppm (45 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 10 ppm (40 mg/m3);Skin JAN 1993 OEL-AUSTRALIA:TWA 10 ppm (45 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 10 ppm (55 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 10 ppm (54 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 10 ppm (54 mg/m3);STEL 20 ppm (110 mg/m3);Skin JAN 1993 OEL-GERMANY:TWA 10 ppm (55 mg/m3);Skin;Carcinogen JAN 1993 OEL-HUNGARY:TWA 10 mg/m3;STEL 20 mg/m3;Skin JAN 1993 OEL-JAPAN:TWA 10 ppm (55 mg/m3);Skin JAN 1993 OEL-THE NETHERLANDS:TWA 10 ppm (45 mg/m3);Skin JAN 1993 OEL-POLAND:TWA 100 mg/m3 JAN 1993 OEL-RUSSIA:TWA 10 ppm JAN 1993 OEL-SWITZERLAND:TWA 10 ppm (55 mg/m3);STEL 50 ppm;Skin JAN 1993 OEL-UNITED KINGDOM:TWA 10 ppm (45 mg/m3);STEL 20 ppm;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 1,1,2-TRICHLOROETHANE-air:10H CA TWA 10 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 73770 No. of Facilities: 1422 (estimated) No. of Industries: 12 No. of Occupations: 18 No. of Employees: 10453 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 73770 No. of Facilities: 95 (estimated) No. of Industries: 4 No. of Occupations: 12 No. of Employees: 1038 (estimated) No. of Female Employees: 16 (estimated)
1,1,2-三氯乙烷安全信息
[ 符号 ]:
GHS02, GHS06, GHS08
[ 信号词 ]:
Danger
[ 危害声明 ]:
H225-H301 + H311 + H331-H370
[ 补充危害声明 ]:
Repeated exposure may cause skin dryness or cracking.
[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311
[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]:
Xn:Harmful;
[ 风险声明 (欧洲) ]:
R20/21/22;R40;R66
[ 安全声明 (欧洲) ]:
S36/37-S46-S9
[ 危险品运输编码 ]:
UN 3082
[ WGK德国 ]:
3
[ RTECS号 ]:
KJ3150000
[ 包装等级 ]:
III
[ 危险类别 ]:
6.1(b)
1,1,2-三氯乙烷合成路线
1,1,2-三氯乙烷上下游产品
1,1,2-三氯乙烷上游产品
1,1,2-三氯乙烷下游产品
1,1,2-三氯乙烷制备
1、氯乙烯氯化法 预先往反应釜内投入三氯乙烷，然后于20-25℃下通入氯乙烯和氯气（摩尔比1：1.2）进行氯化合成。生成物经水洗、分离而得。
2、1,2-二氯乙烷氯化法 在三氯化铝或其他金属氯化物存在下，于60℃氯化即得。
1,1,2-三氯乙烷文献
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A dataset comprising 55 chemicals with hepatocarcinogenic potency indices was collected from the Carcinogenic Potency Database with the aim of developing QSAR models enabling prediction of the above u...
Development of a new extraction method based on counter current salting-out homogenous liquid-liquid extraction followed by dispersive liquid-liquid microextraction: Application for the extraction and preconcentration of widely used pesticides from fruit juices.Talanta 146 , 772-9, (2015)
In this paper, a new extraction method based on counter current salting-out homogenous liquid-liquid extraction (CCSHLLE) followed by dispersive liquid-liquid microextraction (DLLME) has been develope...
Development of counter current salting-out homogenous liquid-liquid extraction for isolation and preconcentration of some pesticides from aqueous samples.Anal. Chim. Acta 885 , 122-31, (2015)
In this paper, a new version of salting-out homogenous liquid-liquid extraction based on counter current mode combined with dispersive liquid-liquid microextraction has been developed for the extracti...
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￥88.0/500g
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￥219.0/5g
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