乙酸甲酯

乙酸甲酯用途

用途一：用作有机溶剂、喷漆人造革及香料等的原料
用途二：GB 2760一1996规定为允许使用的食用香料。
用途三：用作色谱分析标准物质和溶剂，也用于由碱金属氯化物中分离氯化锂及香料的合成
用途四：硝基纤维素和醋酸纤维素的快干性溶剂，用于油漆涂料。还用于人造革及香料的制造以及用作油脂的萃取剂。还是制造染料和药物的原料。

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乙酸甲酯名称

[ CAS 号 ]:
79-20-9

[ 中文名 ]:
乙酸甲酯

[ 英文名 ]:
Methyl acetate

[中文别名 ]:

醋酸甲酯

[英文别名 ]:

methyl ortho-acetate
1-yl-acetic acid,methyl ester
acetic acid trimethyl ester
Methyl ethanoate
Devoton
Methyl acetic ester
MFCD00008711
EINECS 201-185-2
Tereton
Methylacetat

乙酸甲酯物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
44.0±3.0 °C at 760 mmHg

[ 熔点 ]:
-98 °C

[ 分子式 ]:
C₃H₆O₂

[ 分子量 ]:
74.078

[ 闪点 ]:
-9.4±0.0 °C

[ 精确质量 ]:
74.036781

[ PSA ]:
26.30000

[ LogP ]:
0.18

[ 外观性状 ]:
透明液体

[ 蒸汽密度 ]:
2.55 (vs air)

[ 蒸汽压 ]:
368.4±0.1 mmHg at 25°C

[ 折射率 ]:
1.354

[ 储存条件 ]:
Flammables area

[ 稳定性 ]:
Stable. Extremely flammable - readily forms explosive mixtures with air. Note low flash point and wide explosion limits. Incompatible with strong oxidizing agents, strong bases, strong acids, nitrates. May be moisture sensitive.

[ 水溶解性 ]:
250 g/L (20 ºC)

乙酸甲酯MSDS

详细MSDS(安全技术说明书)

乙酸甲酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AI9100000

CHEMICAL NAME :: Acetic acid, methyl ester

CAS REGISTRY NUMBER :: 79-20-9

LAST UPDATED :: 199712

DATA ITEMS CITED :: 49

MOLECULAR FORMULA :: C3-H6-O2

MOLECULAR WEIGHT :: 74.09

WISWESSER LINE NOTATION :: 1VO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human

DOSE/DURATION :: 15000 mg/m3

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Lungs, Thorax, or Respiration - cough Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 32000 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 34 gm/m3/4H

TOXIC EFFECTS :: Behavioral - general anesthetic

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 67 gm/m3/1H

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3705 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraduodenal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 214 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Yeast - Saccharomyces cerevisiae

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 149,339,1985 *** REVIEWS *** ACGIH TLV-STEL 757 mg/m3 (250 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 606 mg/m3 (200 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 21,28,1960 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 200 ppm (610 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,153,1971 OSHA PEL (Gen Indu):8H TWA 200 ppm (610 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 200 ppm (610 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 200 ppm (610 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 200 ppm (610 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 200 ppm (610 mg/m3);STEL 250 ppm (760 mg/m3) JAN 1993 OEL-BELGIUM:TWA 200 ppm (610 mg/m3);STEL 250 ppm (760 mg/m3) JAN 1993 OEL-DENMARK:TWA 200 ppm (610 mg/m3) JAN 1993 OEL-FINLAND:TWA 200 ppm (610 mg/m3);STEL 250 ppm (765 mg/m3) JAN 1993 OEL-FRANCE:TWA 200 ppm (610 mg/m3);STEL 250 ppm (760 mg/m3) JAN 1993 OEL-GERMANY:TWA 200 ppm (610 mg/m3) JAN 1993 OEL-HUNGARY:TWA 200 mg/m3;STEL 500 mg/m3;Skin JAN 1993 OEL-JAPAN:TWA 200 ppm (610 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 200 ppm (610 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 200 ppm (610 mg/m3) JAN 1993 OEL-POLAND:TWA 100 mg/m3 JAN 1993 OEL-RUSSIA:TWA 200 ppm;STEL 100 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 200 ppm (610 mg/m3);STEL 400 ppm JAN 1993 OEL-TURKEY:TWA 200 ppm (610 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 200 ppm (610 mg/m3);STEL 250 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO METHYL ACETATE-air:10H TWA 200 ppm;STEL 250 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 46410 No. of Facilities: 1604 (estimated) No. of Industries: 26 No. of Occupations: 22 No. of Employees: 5611 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 46410 No. of Facilities: 387 (estimated) No. of Industries: 15 No. of Occupations: 31 No. of Employees: 20455 (estimated) No. of Female Employees: 6018 (estimated)

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乙酸甲酯安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H319-H336

[ 补充危害声明 ]:
Repeated exposure may cause skin dryness or cracking.

[ 警示性声明 ]:
P210-P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313-P403 + P235

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
F:Flammable

[ 风险声明 (欧洲) ]:
R11;R36;R66;R67

[ 安全声明 (欧洲) ]:
S16-S26-S29-S33

[ 危险品运输编码 ]:
UN 1231 3/PG 2

[ WGK德国 ]:
1

[ RTECS号 ]:
AI9100000

[ 包装等级 ]:
II

[ 危险类别 ]:
3

乙酸甲酯合成路线

详细合成路线

乙酸甲酯上下游产品

乙酸甲酯上游产品

乙酸甲酯下游产品

乙酸甲酯制备

1.醋酸与甲醇以硫酸为催化剂直接进行酯化反应生成醋酸甲酯粗制品，再用氯化钙脱水，碳酸钠中和，分馏得成品。

精制方法：由于乙酸甲酯容易水解，主要的杂质是游离的乙酸和甲醇。甲醇的存在可从其在水中的溶解度看出。常温下乙酸甲酯在水中溶解24%。若有1%甲醇存在时则可与水混溶。精制时，在1000mL乙酸甲酯中加入85mL乙酸酐，回流6小时后分馏。酸性杂质可用无水碳酸钾一起振摇，再蒸馏除去。甲醇也可用乙酰氯处理除去。高纯度的乙酸甲酯可用浓食盐水洗涤，氧化钙或硫酸镁干燥后蒸馏精制。

2.在搪瓷罐中加入乙酸、甲醇、硫酸回流8h进行反应，然后将粗品蒸出，先用固体氯化钙除去大部分水，再用固体碳酸钠除去酸性，至中性用无水碳酸钾干燥，然后分馏，收集55～58℃馏分，即为成品。

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乙酸甲酯文献

The EpiOcular Eye Irritation Test (EIT) for hazard identification and labelling of eye irritating chemicals: protocol optimisation for solid materials and the results after extended shipment.

Altern. Lab. Anim. 43 , 101-27, (2015)

The 7th Amendment to the EU Cosmetics Directive and the EU REACH Regulation have reinforced the need for in vitro ocular test methods. Validated in vitro ocular toxicity tests that can predict the hum...

Differentiation of South American crack and domestic (US) crack cocaine via headspace-gas chromatography/mass spectrometry.

Drug Test. Anal. 7(3) , 241-6, (2015)

South American 'crack' cocaine, produced directly from coca leaf, can be distinguished from US domestically produced crack on the basis of occluded solvent profiles. In addition, analysis of domestica...

Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).

J. Med. Chem. 48 , 3269-79, (2005)

Growing interest in the use of both the logarithm of the partition coefficient of the neutral species in the alkane/water system (log P(N)(alk)) and the difference between log P(N)(oct) (the logarithm...

更多文献

乙酸甲酯

乙酸甲酯用途

乙酸甲酯名称

乙酸甲酯物理化学性质

乙酸甲酯MSDS

详细MSDS(安全技术说明书)

乙酸甲酯毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

乙酸甲酯安全信息

乙酸甲酯合成路线

详细合成路线

乙酸甲酯上下游产品

乙酸甲酯上游产品

乙酸甲酯下游产品

乙酸甲酯制备

乙酸甲酯文献

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