去乙基阿莫地喹盐酸盐

去乙基阿莫地喹盐酸盐用途

N-Desethyl amodiaquine dihydrochloride 是 Amodiaquine 的主要生物活性代谢产物。N-Desethyl amodiaquine dihydrochloride 是一种抗寄生虫剂,对菌株 V1/S 和 3D7 的 IC50 值分别为 97 nM 和 25 nM。

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去乙基阿莫地喹盐酸盐名称

[ CAS 号 ]:
79049-30-2

[ 中文名 ]:
N-二乙基阿莫地喹二盐酸盐

[ 英文名 ]:
N-Desethyl amodiaquine dihydrochloride

[英文别名 ]:

Desethylamodiaquine hydrochloride

去乙基阿莫地喹盐酸盐生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 抗感染 >> 寄生物

研究领域 >> 感染

[参考文献]

[1]. Sasi P, et al. In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa. J Infect Dis. 2009 Jun 1;199(11):1575-82.

去乙基阿莫地喹盐酸盐物理化学性质

[ 分子式 ]:
C₁₈H₂₀Cl₃N₃O

[ 分子量 ]:
400.73

[ 精确质量 ]:
399.06700

[ PSA ]:
57.18000

[ LogP ]:
6.51480

[ 储存条件 ]:
室温

去乙基阿莫地喹盐酸盐安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311

[ 危险品运输编码 ]:
UN1230 - class 3 - PG 2 - Methanol, solution

去乙基阿莫地喹盐酸盐文献

In vitro susceptibility of Plasmodium falciparum to monodesethylamodiaquine, quinine, mefloquine and halofantrine in Abidjan (Côte d'Ivoire).

Afr. Health Sci. 10(2) , 111-6, (2010)

Malaria is the primary cause of hospitalization in Côte d'Ivoire. Early treatment is one of the strategies to control this illness. However, the spread of resistance of Plasmodium falciparum to antima...

Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue.

Proc. Natl. Acad. Sci. U. S. A. 108(47) , E1214-23, (2011)

Clinical studies and mathematical models predict that, to achieve malaria elimination, combination therapies will need to incorporate drugs that block the transmission of Plasmodium falciparum sexual ...

In vitro assessment of drug resistance in Plasmodium falciparum in five States of India.

Indian J. Med. Res. 135(4) , 494-9, (2012)

In vitro assays are an important tool to assess baseline sensitivity and monitor the drug response of Plasmodium falciparum over time and place and, therefore, can provide background information for t...

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