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20-羟基二十碳-5Z,8Z,11Z,14Z-四烯酸

20-羟基二十碳-5Z,8Z,11Z,14Z-四烯酸用途

20-HETE（20-hydroxy Arachidonic Acid）是血管收缩剂，可去极化血管平滑肌。

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20-羟基二十碳-5Z,8Z,11Z,14Z-四烯酸名称

[ CAS 号 ]:
79551-86-3

[ 中文名 ]:
20-羟基二十碳-5Z,8Z,11Z,14Z-四烯酸

[ 英文名 ]:
20-HETE

[英文别名 ]:

20-hydroxy-5,8,11,14-eicosatetraenoic acid
20-HETE
20-Hydroxyicosatetraenoic acid
DSR-II-247-30
20-Hydroxyeicosatetraenoic acid
20-Hydroxyicosatetraenoate
20-Hydroxy arachidonic acid

20-羟基二十碳-5Z,8Z,11Z,14Z-四烯酸生物活性

[ 描述 ]:

20-HETE(20-hydroxy Arachidonic Acid)是血管收缩剂,可去极化血管平滑肌。

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 跨膜转运 >> 钾通道

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Zou AP, Fleming JT, Falck JR, 20-HETE is an endogenous inhibitor of the large-conductance Ca(2+)-activated K+ channel in renal arterioles. Am J Physiol. 1996 Jan;270(1 Pt 2):R228-37.

[2]. Schwartzman M, Ferreri NR, Carroll MA, Renal cytochrome P450-related arachidonate metabolite inhibits (Na+ + K+)ATPase. Nature. 1985 Apr 18-24;314(6012):620-2.

[3]. Ding Y, Wu CC, Garcia V, 20-HETE INDUCES REMODELING OF RENAL RESISTANCE ARTERIES INDEPENDENT OF BLOOD PRESSURE ELEVATION IN HYPERTENSION. Am J Physiol Renal Physiol. 2013 Jul 3. [Epub ahead of print]

[4]. Lai G, Wu J, Liu X, 20-HETE induces hyperglycemia through the cAMP/PKA-PhK-GP pathway. Mol Endocrinol. 2012 Nov;26(11):1907-16.

20-羟基二十碳-5Z,8Z,11Z,14Z-四烯酸物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
482.0±33.0 °C at 760 mmHg

[ 分子式 ]:
C₂₀H₃₂O₃

[ 分子量 ]:
320.47

[ 闪点 ]:
259.4±21.9 °C

[ 精确质量 ]:
320.235138

[ PSA ]:
57.53000

[ LogP ]:
4.91

[ 外观性状 ]:
液体

[ 蒸汽压 ]:
0.0±2.7 mmHg at 25°C

[ 折射率 ]:
1.515

[ 储存条件 ]:
−20°C

20-羟基二十碳-5Z,8Z,11Z,14Z-四烯酸MSDS

20-羟基二十碳-5Z,8Z,11Z,14Z-四烯酸安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H319

[ 警示性声明 ]:
P210-P305 + P351 + P338-P370 + P378-P403 + P235

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
F: Flammable;Xi: Irritant;

[ 风险声明 (欧洲) ]:
11-36/37/38

[ 安全声明 (欧洲) ]:
16-26-36

[ 危险品运输编码 ]:
UN 1170 3/PG 2

[ WGK德国 ]:
3

20-羟基二十碳-5Z,8Z,11Z,14Z-四烯酸合成路线

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20-羟基二十碳-5Z,8Z,11Z,14Z-四烯酸文献

HMDB: a knowledgebase for the human metabolome.

Nucleic Acids Res. 37(Database issue) , D603-10, (2009)

The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, ...

The human serum metabolome.

PLoS ONE 6(2) , e16957, (2011)

Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the m...

IGF-1 deficiency impairs cerebral myogenic autoregulation in hypertensive mice.

J. Cereb. Blood Flow Metab. 34(12) , 1887-97, (2014)

Aging impairs autoregulatory protection in the brain, exacerbating hypertension-induced cerebromicrovascular injury, neuroinflammation, and development of vascular cognitive impairment. Despite the im...

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