20-carboxy Leukotriene B4

20-carboxy Leukotriene B4用途

20-羧基白三烯B4(20-COOH LTB4)是白三烯B2(LTB4；HY-107608)的代谢产物。20-羧基白三烯B4以高亲和力结合BLT1受体。20羧基白三烯B4抑制LTB4介导的中性粒细胞反应(迁移、脱颗粒、白三烯生物合成)[1]。

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20-carboxy Leukotriene B4名称

[ CAS 号 ]:
80434-82-8

[ 中文名 ]:
20-羧基白三烯B4

[ 英文名 ]:
20-hydroxy-20-oxoleukotriene B4

[英文别名 ]:

20-carboxy-LTB4
20-hydroxy-20-oxoleukotriene B4
20-COOH-LTB4
20-carboxyleukotriene B4
20-COOH-Leukotriene B4
MFCD00065857

20-carboxy Leukotriene B4生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 代谢疾病

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Anne-Sophie Archambault, et al. 20-Hydroxy- and 20-carboxy-leukotriene (LT) B4 downregulate LTB4 -mediated responses of human neutrophils and eosinophils. J Leukoc Biol. 2019 Jun;105(6):1131-1142.

20-carboxy Leukotriene B4物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
588.3±50.0 °C at 760 mmHg

[ 分子式 ]:
C₂₀H₃₀O₆

[ 分子量 ]:
366.449

[ 闪点 ]:
323.6±26.6 °C

[ 精确质量 ]:
366.204254

[ PSA ]:
115.06000

[ LogP ]:
2.02

[ 蒸汽压 ]:
0.0±3.7 mmHg at 25°C

[ 折射率 ]:
1.548

[ 储存条件 ]:
-20°C，密闭，干燥

20-carboxy Leukotriene B4MSDS

20-carboxy Leukotriene B4安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H315-H319-H335

[ 警示性声明 ]:
P210-P261-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F,Xi

[ 风险声明 (欧洲) ]:
11-36/37/38

[ 安全声明 (欧洲) ]:
16-26-36

[ 危险品运输编码 ]:
UN 1170 3/PG 2

20-carboxy Leukotriene B4合成路线

20-carboxy Leukotriene B4上下游产品

20-carboxy Leukotriene B4上游产品

20-carboxy Leukotriene B4下游产品

20-carboxy Leukotriene B4文献

The human serum metabolome.

PLoS ONE 6(2) , e16957, (2011)

Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the m...

Identification and biological activity of novel omega-oxidized metabolites of leukotriene B4 from human leukocytes.

FEBS Lett. 130(1) , 107-12, (1981)

Defective metabolism of leukotriene B4 in the Sjögren-Larsson syndrome.

J. Neurol. Sci. 183(1) , 61-7, (2001)

The Sjögren-Larsson Syndrome (SLS) is a neurocutaneous disorder, caused by deficient activity of the microsomal enzyme fatty aldehyde dehydrogenase (FALDH). FALDH catalyzes the oxidation of medium- an...

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