20-carboxy Leukotriene B4
20-carboxy Leukotriene B4结构式
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常用名 | 20-carboxy Leukotriene B4 | 英文名 | 20-hydroxy-20-oxoleukotriene B4 |
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| CAS号 | 80434-82-8 | 分子量 | 366.449 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 588.3±50.0 °C at 760 mmHg | |
| 分子式 | C20H30O6 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 323.6±26.6 °C | |
| 符号 |
GHS02, GHS07 |
信号词 | Danger |
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The human serum metabolome.
PLoS ONE 6(2) , e16957, (2011) Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the metabolomics community to develop centralized metabolite ref... |
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Identification and biological activity of novel omega-oxidized metabolites of leukotriene B4 from human leukocytes.
FEBS Lett. 130(1) , 107-12, (1981)
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Defective metabolism of leukotriene B4 in the Sjögren-Larsson syndrome.
J. Neurol. Sci. 183(1) , 61-7, (2001) The Sjögren-Larsson Syndrome (SLS) is a neurocutaneous disorder, caused by deficient activity of the microsomal enzyme fatty aldehyde dehydrogenase (FALDH). FALDH catalyzes the oxidation of medium- and long-chain fatty aldehydes to their corresponding carboxy... |
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Biosynthesis and metabolism of leukotrienes.
Biochem. J. 405(3) , 379-95, (2007) Leukotrienes are metabolites of arachidonic acid derived from the action of 5-LO (5-lipoxygenase). The immediate product of 5-LO is LTA4 (leukotriene A4), which is enzymatically converted into either LTB4 (leukotriene B4) by LTA4 hydrolase or LTC4 (leukotrien... |
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Rearrangement of 5S, 12S-dihydroxy-6,8,10,14-(E,Z,E,Z)-eicosatetraenoic acid during gas chromatography: formation of a cyclohexadiene derivative.
Prostaglandins 35(5) , 723-31, (1988) The 5S, 12S-dihydroxy-6,8,10,14-(E,Z,E,Z,)-eicosatetraenoic acid, a product of double dioxygenation of arachidonic acid by lipoxygenases, undergoes severe decomposition during gas chromatography-mass spectrometric (GC-MS) analysis of the trimethylsilyl ether ... |
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Metabolism of leukotriene B4 by polymorphonuclear granulocytes of severely burned patients.
Prostaglandins. Leukot. Med. 27(2-3) , 209-25, (1987) Leukotriene B4 release from polymorphonuclear granulocytes of severely burned patients was reduced as compared to healthy donor cells. This decrease is due to an enhanced conversion of LTB4 into the 20-hydroxy- and 20-carboxy-metabolites and further to a decr... |
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NAD+-dependent oxidation of 20-hydroxyleukotriene B4 to 20-carboxyleukotriene B4 by rat liver cytosol.
Biochim. Biophys. Acta 960(3) , 342-50, (1988) 20-Hydroxyleukotriene B4 was converted by rat liver homogenates in the presence of NAD+ to a more polar product on reverse-phase high-performance liquid chromatography. The product was identified as 20-carboxyleukotriene B4 by straight-phase high performance ... |
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Oxidation of 20-hydroxyleukotriene B4 to 20-carboxyleukotriene B4 by human neutrophil microsomes. Role of aldehyde dehydrogenase and leukotriene B4 omega-hydroxylase (cytochrome P-450LTB omega) in leukotriene B4 omega-oxidation.
J. Biol. Chem. 265(8) , 4348-53, (1990) Leukotriene B4 (LTB4), a potent chemoattractant for leukocytes, is catabolized by human neutrophils via omega-oxidation. Neutrophil microsomes are known to oxidize 20-hydroxy-LTB4 (20-OH-LTB4) to its 20-oxo and 20-carboxy derivatives in the presence of NADPH.... |
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Stereochemical analysis and biological activity of 3-hydroxy-leukotriene B4: a metabolite from ethanol-treated rat hepatocytes.
J. Pharmacol. Exp. Ther. 271(3) , 1514-9, (1994) Leukotriene B4 (LTB4), a biologically active metabolite derived from arachidonic acid by the 5-lipoxygenase cascade, is inactivated by cytochrome P-450-dependent omega-hydroxylation followed by second oxidation into a omega-carboxyl group. In many tissues, th... |
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Altered arachidonic acid metabolism in granulocytes of polytraumatized patients.
Prostaglandins. Leukot. Med. 27(2-3) , 227-36, (1987) The generation and metabolism of leukotrienes (LTs) from polymorphonuclear granulocytes of four polytraumatic patients on stimulation with the Ca-Ionophore A 23187 were studied by high performance liquid chromatography. In contrast to healthy donors the conce... |