1,8-二羟基-4,5-二硝基蒽醌

1,8-二羟基-4,5-二硝基蒽醌用途

1,8-二羟基-4,5-二硝基蒽醌(ARDP006；DHDNE)是登革热病毒蛋白丝氨酸蛋白酶NS2B/3的有效抑制剂。1,8-二羟基-4,5-二硝基蒽醌具有分子间蛋白酶活性和病毒抑制能力,IC50分别为432μM和4.2μM。同时,1,8-二羟基-4,5-二硝基蒽醌以4.2μM至432μM的剂量抑制BHK-21细胞中NS2B/3的切割[1]。

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1,8-二羟基-4,5-二硝基蒽醌名称

[ CAS 号 ]:
81-55-0

[ 中文名 ]:
1,8-二羟基-4,5-二硝基蒽醌

[ 英文名 ]:
1,8-Dihydroxy-4,5-dinitroanthraquinone

[中文别名 ]:

[英文别名 ]:

4,5-Dinitrochrysazin
1,8 DIHYDROXY 4,5 DINITRO AQ
4,5-Dinitrodanthron
1,8-dihydroxy-4,5-dinitroanthra-9,10-quinone
1,8-dihydroxy-4,5-dinitro-anthraquinon
Dihydroxy-4,5-dinitroanthraquinone
MFCD00019149
1,8-Dihydroxy-4,5-dinitroanthracene-9,10-dione
1,8-Dihydroxy-4,5-dinitro-anthrachinon
1,8-dihydroxy-4,5-dinitro-anthraquinone

1,8-二羟基-4,5-二硝基蒽醌生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

[体外研究]

1,8-二羟基-4,5-二硝基蒽醌(50μM-2 mM；90分钟) 抑制国家标准2b/3裂解,并在 100微米时显着且显着地作用于制动马力-21细胞[1]。

[参考文献]

[1]. Constant DA, et al. Targeting intramolecular proteinase NS2B/3 cleavages for trans-dominant inhibition of dengue virus. Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10136-10141.

1,8-二羟基-4,5-二硝基蒽醌物理化学性质

[ 密度 ]:
1.8±0.1 g/cm3

[ 沸点 ]:
669.4±55.0 °C at 760 mmHg

[ 熔点 ]:
225 °C (dec.)(lit.)

[ 分子式 ]:
C₁₄H₆N₂O₈

[ 分子量 ]:
330.206

[ 闪点 ]:
280.8±20.0 °C

[ 精确质量 ]:
330.012421

[ PSA ]:
166.24000

[ LogP ]:
4.94

[ 外观性状 ]:
褐色金色固体

[ 蒸汽压 ]:
0.0±2.1 mmHg at 25°C

[ 折射率 ]:
1.782

[ 储存条件 ]:
室温，密封，干燥

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

1,8-二羟基-4,5-二硝基蒽醌MSDS

1,8-二羟基-4,5-二硝基蒽醌毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CB6700000

CHEMICAL NAME :: Anthraquinone, 1,8-dihydroxy-4,5-dinitro-

CAS REGISTRY NUMBER :: 81-55-0

BEILSTEIN REFERENCE NO. :: 2182054

LAST UPDATED :: 199710

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C14-H6-N2-O8

MOLECULAR WEIGHT :: 330.22

WISWESSER LINE NOTATION :: L C666 BVIVJ DQ GNW KNW NQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 10 ug/plate

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 9(Suppl 9),1,1987

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1,8-二羟基-4,5-二硝基蒽醌安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
CB6700000

[ 海关编码 ]:
2914700090

1,8-二羟基-4,5-二硝基蒽醌合成路线

1,8-二羟基-4,5-二硝基蒽醌上下游产品

1,8-二羟基-4,5-二硝基蒽醌上游产品

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1,8-二羟基-4,5-二硝基蒽醌海关

[ 海关编码 ]: 2914700090

[ 中文概述 ]:
2914700090 其他酮及醌的卤化、磺化衍生物（包括硝化和亚硝化衍生物）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

1,8-二羟基-4,5-二硝基蒽醌文献

Catalysed hydrogenation of hydroxynitroanthraquinones in strong acid. Morley JO and Hutcheson R.

J. Chem. Technol. Biotechnol. 30(1) , 409-414, (1980)

Measurement and Correlation of Derivatized Anthraquinone Solubility in Supercritical Carbon Dioxide. Alwi RS and Tamura K.

J. Chem. Eng. Data 60(10) , 3046-3052, (2015)

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