< 生产厂家价格 >

NSC 33994

NSC 33994用途

NSC 33994 (G6) 是选择性的 JAK2 抑制剂,其 IC50 值为 60 nM。

点击显示

NSC 33994名称

[ CAS 号 ]:
82058-16-0

[ 英文名 ]:
NSC 33994

[英文别名 ]:

NSC 33994生物活性

[ 描述 ]:

NSC 33994 (G6) 是选择性的 JAK2 抑制剂,其 IC50 值为 60 nM。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> JAK/STAT信号通路 >> JAK

信号通路 >> 表观遗传学 >> JAK

信号通路 >> 干细胞及 Wnt 通路 >> JAK

[ 靶点 ]

JAK2:60 nM (IC50, JAK2 Val617Phe kinase activity )

[体外研究]

NSC 33994(G6)以剂量和时间依赖的方式降低磷酸化JAK2的水平[1]。NSC 33994(G6,0-25μM,0-48h)以剂量依赖和时间依赖的方式抑制磷酸化JAK2(pY1007/pY1008)[1]。

[参考文献]

[1]. Róbert Kiss, et al. Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3598-601.

NSC 33994物理化学性质

[ 分子式 ]:
C₂₈H₄₂N₂O₂

[ 分子量 ]:
438.64500

[ 精确质量 ]:
438.32500

[ PSA ]:
46.94000

[ LogP ]:
6.51220

[ 外观性状 ]:
固体

[ 储存条件 ]:
2-8°C，密封，干燥

NSC 33994MSDS

NSC 33994安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

NSC 33994合成路线

NSC 33994文献

PTK6/BRK is expressed in the normal mammary gland and activated at the plasma membrane in breast tumors.

Oncotarget 5(15) , 6038-48, (2014)

Protein Tyrosine kinase 6 (PTK6/BRK) is overexpressed in the majority of human breast tumors and breast tumor cell lines. It is also expressed in normal epithelial linings of the gastrointestinal trac...

RNA-dependent protein kinase (PKR) depletes nutrients, inducing phosphorylation of AMP-activated kinase in lung cancer.

Oncotarget 6 , 11114-24, (2015)

We have demonstrated that RNA-dependent protein kinase (PKR) and its downstream protein p-eIF2α are independent prognostic markers for overall survival in lung cancer. In the current study, we further...

Diosmin induces genotoxicity and apoptosis in DU145 prostate cancer cell line.

Toxicol. In Vitro 29(3) , 417-25, (2015)

Plant-derived dietary polyphenolic compounds, such as flavonoids, with cancer cell-specific pro-apoptotic activity and chemopreventive potential are thought to be promising anticancer agents. In the p...

更多文献

NSC 33994

NSC 33994用途

NSC 33994名称

NSC 33994生物活性

NSC 33994物理化学性质

NSC 33994MSDS

详细MSDS(安全技术说明书)

NSC 33994安全信息

NSC 33994合成路线

详细合成路线

NSC 33994文献

推荐生产厂家/供应商：

相关化合物