2,6-二羟基蒽醌

2,6-二羟基蒽醌用途

Anthraflavic acid 是一种类黄酮,有效的 IQ 诱变性抑制剂,可以抑制微粒体和胞质激活途径。 Anthraflavic acid 也是一种有效和特异性的细胞色素 P-448 抑制剂,细胞色素 P-448 是一种与许多化学致癌物质的激活密切相关的酶系统。

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2,6-二羟基蒽醌名称

[ CAS 号 ]:
84-60-6

[ 中文名 ]:
2,6-二羟基蒽醌

[ 英文名 ]:
2,6-DIHYDROXY-ANTHRAQUINONE

[中文别名 ]:

[英文别名 ]:

2,6-DIHYDROXY-ANTHRAQUINONE
2,6-Dihydroxy-9,10-anthraquinone
EINECS 201-544-3
2,6-DIHYDROXYANTHRAQUINONE
MFCD00001228
9,10-Anthracenedione, 2,6-dihydroxy-
2,6-Dihydroxyanthracene-9,10-dione

2,6-二羟基蒽醌生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Ayrton AD, et al. Anthraflavic acid inhibits the mutagenicity of the food mutagen IQ: mechanism of action. Mutat Res. 1988 Mar-Apr;207(3-4):121-5.

2,6-二羟基蒽醌物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
442.1±35.0 °C at 760 mmHg

[ 熔点 ]:
>320 °C(lit.)

[ 分子式 ]:
C₁₄H₈O₄

[ 分子量 ]:
240.211

[ 闪点 ]:
235.3±22.4 °C

[ 精确质量 ]:
240.042252

[ PSA ]:
74.60000

[ LogP ]:
3.36

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.733

[ 储存条件 ]:
室温，干燥

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

2,6-二羟基蒽醌MSDS

2,6-二羟基蒽醌毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CB6675000

CHEMICAL NAME :: Anthraquinone, 2,6-dihydroxy-

CAS REGISTRY NUMBER :: 84-60-6

BEILSTEIN REFERENCE NO. :: 2054127

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C14-H8-O4

MOLECULAR WEIGHT :: 240.22

WISWESSER LINE NOTATION :: L C666 BV IVJ DQ LQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 ug/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 40,203,1976

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2,6-二羟基蒽醌安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
CB6675000

[ 海关编码 ]:
2914690090

2,6-二羟基蒽醌合成路线

2,6-二羟基蒽醌上下游产品

2,6-二羟基蒽醌上游产品

2,6-二羟基蒽醌下游产品

2,6-二羟基蒽醌海关

[ 海关编码 ]: 2914690090

[ 中文概述 ]:
2914690090 其他醌. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ Summary ]:
2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

2,6-二羟基蒽醌文献

Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity.

Bioorg. Med. Chem. Lett. 11(14) , 1839-42, (2001)

The methanolic extract from the roots of Polygonum (P.) cuspidatum was found to enhance cell proliferation at 30 or 100 microg/mL in MCF-7, an estrogen-sensitive cell line. By bioassay-guided separati...

Mutagenicity of anthraquinone and hydroxylated anthraquinones in the Ames/Salmonella microsome system.

Appl. Environ. Microbiol. 43(6) , 1354-9, (1982)

The mutagenicity of anthracene, anthraquinone, and four structurally similar compounds of each was evaluated in the Ames/Salmonella microsome assay. Anthraquinone was shown to be mutagenic for strains...

A compact optical instrument with artificial neural network for pH determination.

Sensors (Basel.) 12 , 6746-63, (2012)

The aim of this work was the determination of pH with a sensor array-based optical portable instrument. This sensor array consists of eleven membranes with selective colour changes at different pH int...

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