异丁嗪

异丁嗪用途

Alimemazine 是通常用作止痒剂的吩噻嗪衍生物,也是血凝素 (HA)- 受体的拮抗剂。Alimemazine (Trimeprazine) 是也是针对组胺H1受体 (H1R) 和其他 GPCR 的部分激动剂。Alimemazine 具有镇静、抗血清素、抗痉挛和止吐作用。

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异丁嗪名称

[ CAS 号 ]:
84-96-8

[ 中文名 ]:
异丁嗪

[ 英文名 ]:
Trimeprazine

[中文别名 ]:

[英文别名 ]:

Methylpromazine
Isobutrazine
EINECS 201-577-3
Repetin
Alimemazine
Alimezine
dl-Trimeprazine
Teralen
10-[3-(dimethylamino)-2-methylpropyl]phenothiazine
Trimeprazine

异丁嗪生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

研究领域 >> 神经疾病

[ 靶点 ]

HA receptor[1]

[参考文献]

[1]. Singh B, et al. Bioanalytical method development and validation of alimemazine in human plasma by LC-MS/MS and its application in bioequivalence studies. J Pharm Bioallied Sci. 2013 Oct;5(4):257-64.

[2]. Kuznetsova A, et al. Trimeprazine increases IRS2 in human islets and promotes pancreatic β cell growth and function in mice. JCI Insight. 2016;1(3).

异丁嗪物理化学性质

[ 密度 ]:
1.203 g/cm3

[ 沸点 ]:
420.3ºC at 760mmHg

[ 熔点 ]:
68°C

[ 分子式 ]:
C₁₈H₂₂N₂S

[ 分子量 ]:
298.44600

[ 闪点 ]:
208ºC

[ 精确质量 ]:
298.15000

[ PSA ]:
31.78000

[ LogP ]:
4.55200

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放

[ 水溶解性 ]:
0.942 mg/L

异丁嗪毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SO5700000

CHEMICAL NAME :: Phenothiazine, 10-(3-(dimethylamino)-2-methylpropyl)-

CAS REGISTRY NUMBER :: 84-96-8

LAST UPDATED :: 199512

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C18-H22-N2-S

MOLECULAR WEIGHT :: 298.48

WISWESSER LINE NOTATION :: T C666 BN ISJ B1Y1&1N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 210 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANPBAZ Acta Neurologia et Psychiatrica Belgica. (Brussels, Belgium) V.48-69, 1948-69. For publisher information, see ANUBBR. Volume(issue)/page/year: 61,669,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANPBAZ Acta Neurologia et Psychiatrica Belgica. (Brussels, Belgium) V.48-69, 1948-69. For publisher information, see ANUBBR. Volume(issue)/page/year: 61,669,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Behavioral - antipsychotic

REFERENCE :: DNEUD5 Developments in Neuroscience (Amsterdam). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1977- Volume(issue)/page/year: 7,45,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 33 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4969 No. of Facilities: 32 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 333 (estimated) No. of Female Employees: 227 (estimated)

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异丁嗪安全信息

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R36/37/38:Irritating to eyes, respiratory system and skin .

[ 安全声明 (欧洲) ]:
S22:Do not breathe dust . S24/25:Avoid contact with skin and eyes . S36:Wear suitable protective clothing . S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .

[ 危险品运输编码 ]:
2811

[ WGK德国 ]:
3

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

异丁嗪