2-Methyl-5-HT hydrochloride

2-Methyl-5-HT hydrochloride用途

2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) 是一种有效的选择性 5-HT3 受体激动剂。2-Methyl-5-HT hydrochloride 显示出抗抑郁样作用。

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2-Methyl-5-HT hydrochloride名称

[ CAS 号 ]:
845861-49-6

[ 英文名 ]:
2-Methyl-5-HT hydrochloride

[英文别名 ]:

2-Methylserotonin.HCl

2-Methyl-5-HT hydrochloride生物活性

[ 描述 ]:

2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) 是一种有效的选择性 5-HT3 受体激动剂。2-Methyl-5-HT hydrochloride 显示出抗抑郁样作用。

[ 靶点 ]

5-HT3 Receptor

[体内研究]

与对照相比,2-甲基-5-HT盐酸盐(2-甲基-5-羟色胺盐酸盐)(i.p.；3mg/kg；45分钟)显着减少不动时间,因此显示出抗抑郁样作用[1]。动物模型：雄性Sprague-Dawley大鼠[1]剂量：3mg/kg给药：腹膜内；45分钟结果：显着减少不动时间,因此显示出抗抑郁样作用。

[参考文献]

[1]. Sumaya IC, et al. Differential effects of a short-term high-fat diet in an animal model of depression in rats treated with the 5-HT3 receptor antagonist, ondansetron, the 5-HT3 receptor agonist, 2-methyl-5-HT, and the SSRI, fluoxetine. Pharmacol Biochem Behav. 2016 May;144:78-84.

2-Methyl-5-HT hydrochloride物理化学性质

[ 分子式 ]:
C₁₁H₁₅ClN₂O

[ 分子量 ]:
226.70300

[ 精确质量 ]:
226.08700

[ PSA ]:
62.04000

[ LogP ]:
3.18540

2-Methyl-5-HT hydrochloride安全信息

[ 海关编码 ]:
2933990090

2-Methyl-5-HT hydrochloride海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%