诺孕烯酮

诺孕烯酮用途

去甲孕酮,孕激素或合成孕激素,是一种孕激素受体激动剂。去甲三烯酮常用作避孕药中的孕激素化合物,可与炔雌醇联合使用[1]。

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诺孕烯酮名称

[ CAS 号 ]:
848-21-5

[ 中文名 ]:
诺孕烯酮

[ 英文名 ]:
Norgestrienone

[中文别名 ]:

三烯炔诺酮

[英文别名 ]:

Ethynyl trienolone
Ogyline

诺孕烯酮生物活性

[ 描述 ]:

去甲孕酮,孕激素或合成孕激素,是一种孕激素受体激动剂。去甲三烯酮常用作避孕药中的孕激素化合物,可与炔雌醇联合使用[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 孕激素受体

研究领域 >> 内分泌

诺孕烯酮物理化学性质

[ 密度 ]:
1.21g/cm3

[ 沸点 ]:
498.1ºC at 760 mmHg

[ 熔点 ]:
169ºC

[ 分子式 ]:
C₂₀H₂₂O₂

[ 分子量 ]:
294.38700

[ 闪点 ]:
211.2ºC

[ 精确质量 ]:
294.16200

[ PSA ]:
37.30000

[ LogP ]:
3.33270

[ 折射率 ]:
1.615

诺孕烯酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RC8960080

CHEMICAL NAME :: 19-Nor-17-alpha-pregna-4,9,11-trien-20-yn-3-one, 17-hydroxy-

CAS REGISTRY NUMBER :: 848-21-5

LAST UPDATED :: 199706

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C20-H22-O2

MOLECULAR WEIGHT :: 294.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

DOSE :: 1168 ug/kg

SEX/DURATION :: female 52 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 18,411,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

DOSE :: 1642 ug/kg

SEX/DURATION :: female 52 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 18,429,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravaginal

DOSE :: 1 mg/kg

SEX/DURATION :: female 36 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 20,511,1979