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6-硫基鸟嘌呤

6-硫基鸟嘌呤用途

6-Thioguanosine (6-Mercaptoguanosine) 是一种活性核苷,是 Azathioprine 的代谢物。6-Thioguanosine 具有免疫抑制作用。

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6-硫基鸟嘌呤名称

[ CAS 号 ]:
85-31-4

[ 中文名 ]:
6-巯基鸟嘌呤核苷

[ 英文名 ]:
6-Thioguanosine

[中文别名 ]:

[英文别名 ]:

2-amino-6-mercaptopurine ribose
thioguanosine
sri759
EINECS 201-597-2
6-MERCAPTOGUANOSINE
6-thio-guanosine
6-thioguanineribose
ribosylthioguanine
6-thio-guanosin
2-AMINO-6-MERCAPTOPURINE-9-D-RIBOSIDE HYDRATE

6-硫基鸟嘌呤生物活性

[ 描述 ]:

6-Thioguanosine (6-Mercaptoguanosine) 是一种活性核苷,是 Azathioprine 的代谢物。6-Thioguanosine 具有免疫抑制作用。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物

[参考文献]

[1]. Amedeo De Nicolò, et al. UPLC-MS/MS method for quantification of the azathioprine metabolites 6-mercaptoguanosine and 6-methylmercaptopurine riboside in peripheral blood mononuclear cells. J Pharm Biomed Anal. 2014 Sep;98:271-8.

6-硫基鸟嘌呤物理化学性质

[ 密度 ]:
2.18 g/cm3

[ 沸点 ]:
756.9ºC at 760 mmHg

[ 熔点 ]:
230-231°C

[ 分子式 ]:
C₁₀H₁₃N₅O₄S

[ 分子量 ]:
299.31

[ 闪点 ]:
411.6ºC

[ 精确质量 ]:
299.06900

[ PSA ]:
174.53000

[ 外观性状 ]:
黄色-绿色粉末

[ 储存条件 ]:
-20°C Freezer

6-硫基鸟嘌呤MSDS

详细MSDS(安全技术说明书)

6-硫基鸟嘌呤毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UP0200000

CHEMICAL NAME :: 9H-Purine-6-thiol, 2-amino-9-beta-D-ribofuranosyl-

CAS REGISTRY NUMBER :: 85-31-4

LAST UPDATED :: 199410

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H13-N5-O4-S

MOLECULAR WEIGHT :: 299.34

WISWESSER LINE NOTATION :: T56 BN DN FN HNJ GZ ISH D- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72. Discontinued. Volume(issue)/page/year: 3,181,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 156 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986

TYPE OF TEST :: LD10 - Lethal Dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 7,69,1970 *** REVIEWS *** TOXICOLOGY REVIEW 32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York, Springer, 1975 Volume(issue)/page/year: -,49,1975

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6-硫基鸟嘌呤安全信息

[ 风险声明 (欧洲) ]:
24/25

[ RTECS号 ]:
UP0200000

[ 海关编码 ]:
2934999090

6-硫基鸟嘌呤上下游产品

6-硫基鸟嘌呤上游产品

6-硫基鸟嘌呤下游产品

6-硫基鸟嘌呤海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%