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6-甲氧基-8-硝基喹啉

6-甲氧基-8-硝基喹啉用途

【用途一】
该品可作抗疟药磷酸伯氨喹的中间体。

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6-甲氧基-8-硝基喹啉名称

[ CAS 号 ]:
85-81-4

[ 中文名 ]:
6-甲氧基-8-硝基喹啉

[ 英文名 ]:
6-Methoxy-8-nitroquinoline

[中文别名 ]:

6-甲氧-8-硝喹啉

[英文别名 ]:

6-Methoxy-8-nitroquinoline
Quinoline, 6-methoxy-8-nitro-
MFCD00006802
EINECS 201-633-7

6-甲氧基-8-硝基喹啉物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
373.1±27.0 °C at 760 mmHg

[ 熔点 ]:
158-160 °C(lit.)

[ 分子式 ]:
C₁₀H₈N₂O₃

[ 分子量 ]:
204.182

[ 闪点 ]:
179.4±23.7 °C

[ 精确质量 ]:
204.053497

[ PSA ]:
67.94000

[ LogP ]:
1.86

[ 外观性状 ]:
固体;White to Light yellow powder to crystal

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.646

[ 储存条件 ]:
室温，干燥

6-甲氧基-8-硝基喹啉MSDS

6-甲氧基-8-硝基喹啉毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VC0365000

CHEMICAL NAME :: Quinoline, 6-methoxy-8-nitro-

CAS REGISTRY NUMBER :: 85-81-4

BEILSTEIN REFERENCE NO. :: 0168992

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H8-N2-O3

MOLECULAR WEIGHT :: 204.20

WISWESSER LINE NOTATION :: T66 BNJ HO1 JNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 nmol/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 58,11,1978

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6-甲氧基-8-硝基喹啉安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302 + H312 + H332-H315-H319-H335-H351

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22;R36/37/38;R40

[ 安全声明 (欧洲) ]:
S26-S27-S36/37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
VC0365000

[ 海关编码 ]:
2933499090

6-甲氧基-8-硝基喹啉合成路线

6-甲氧基-8-硝基喹啉制备

由4-甲氧基-2-硝基苯胺经环合反应而得。将甘油加入反应锅内，在70℃以下加入硫酸，再投入4-甲氧基-2-硝基苯胺。在75-80℃保温后加入碘化钾和碘的水溶液，升温至125℃，保温直至反应到达终点。用冰水稀释，在35℃以下用氢氧化钠溶液中和至pH 值为3.5，过滤，水洗至pH值为5，得6-甲氧基-8-硝基喹啉。收率为90%。

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6-甲氧基-8-硝基喹啉海关

[ 海关编码 ]: 2933499090

[ 中文概述 ]:
2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

6-甲氧基-8-硝基喹啉文献

Ring-substituted quinolines as potential anti-tuberculosis agents.

Bioorg. Med. Chem. 12(10) , 2501-8, (2004)

We report in vitro antimycobacterial properties of ring-substituted quinolines (series 1-4) constituting 56 analogues against drug-sensitive and drug-resistant M. tuberculosis H37Rv strains. The most ...

Primaquine-induced hemolytic anemia: formation and hemotoxicity of the arylhydroxylamine metabolite 6-methoxy-8-hydroxylaminoquinoline.

J. Pharmacol. Exp. Ther. 297(2) , 509-15, (2001)

Primaquine is an important antimalarial agent because of its activity against exoerythrocytic forms of Plasmodium spp. However, methemoglobinemia and hemolytic anemia are dose-limiting side effects of...

更多文献

6-甲氧基-8-硝基喹啉

6-甲氧基-8-硝基喹啉用途

6-甲氧基-8-硝基喹啉名称

6-甲氧基-8-硝基喹啉物理化学性质

6-甲氧基-8-硝基喹啉MSDS

详细MSDS(安全技术说明书)

6-甲氧基-8-硝基喹啉毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

6-甲氧基-8-硝基喹啉安全信息

6-甲氧基-8-硝基喹啉合成路线

详细合成路线

6-甲氧基-8-硝基喹啉制备

6-甲氧基-8-硝基喹啉海关

6-甲氧基-8-硝基喹啉文献

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