N-[3,5-二(三氟甲基)苯基]-N'-[(9R)-6'-甲氧基奎宁-9-基]硫脲

名称

[ 中文名 ]:
N-[3,5-双(三氟甲基)苯基]-N′-[(9R)-6′-甲氧基-9-金鸡宁]硫脲

[ 英文名 ]:
1-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)-3-((1R)-(6-METHOXYQUINOLIN-4-YL)((2R,4S,5R)-5-VINYLQUINUCLIDIN-2-YL)METHYL)THIOUREA

[英文别名 ]:

1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]PROPANOL-1 MIN.
1-[3,5-bis(trifluoromethyl)phenyl]-1-propanol
1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]PROPANOL-1

物理化学性质

[ 熔点 ]:
150°C

[ 分子式 ]:
C₂₉H₂₈F₆N₄OS

[ 分子量 ]:
594.61400

[ 精确质量 ]:
594.18900

[ PSA ]:
81.51000

[ LogP ]:
7.60690

[ 储存条件 ]:
室温，干燥

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

合成路线

详细合成路线

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文献

Urea- and thiourea-substituted cinchona alkaloid derivatives as highly efficient bifunctional organocatalysts for the asymmetric addition of malonate to nitroalkenes: inversion of configuration at C9 dramatically improves catalyst performance.

Angew. Chem. Int. Ed. Engl. 44 , 6367-6370, (2005)

Highly enantioselective conjugate addition of nitromethane to chalcones using bifunctional cinchona organocatalysts.

Org. Lett. 7 , 1967-1969, (2005)

Cinchona alkaloid-derived chiral bifunctional thiourea organocatalysts were synthesized and applied in the Michael addition between nitromethane and chalcones with high ee and chemical yields.

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