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查摸丁卡

查摸丁卡用途

胸腺生成素(胸腺生成素II(32-35))是胸腺因子(胸腺生成肽)的32-35片段。Thymocartin已显示出在免疫缺陷疾病研究中的潜力[1][2]。

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查摸丁卡名称

[ CAS 号 ]:
85466-18-8

[ 中文名 ]:
查摸丁卡

[ 英文名 ]:
Thymopoietin II: 32-35

[中文别名 ]:

胸腺卡汀

[英文别名 ]:

Rgh 0206
Thymocartina [INN-Spanish]
Thymocartine [INN-French]
Thymocartinum [INN-Latin]
Thymocartina
Thymocartin
Thymopoietin II: 32-35

查摸丁卡生物活性

[ 描述 ]:

胸腺生成素(胸腺生成素II(32-35))是胸腺因子(胸腺生成肽)的32-35片段。Thymocartin已显示出在免疫缺陷疾病研究中的潜力[1][2]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. S Lang, et al. Transport and metabolic pathway of thymocartin (TP4) in excised bovine nasal mucosa. J Pharm Pharmacol. 1996 Nov;48(11):1190-6.

[2]. Ch B Felder, et al. Ultrasonic atomization and subsequent polymer desolvation for peptide and protein microencapsulation into biodegradable polyesters. J Microencapsul. 2003 Sep-Oct;20(5):553-67.

查摸丁卡物理化学性质

[ 密度 ]:
1.45g/cm3

[ 分子式 ]:
C₂₁H₄₀N₈O₇

[ 分子量 ]:
516.59200

[ 精确质量 ]:
516.30200

[ PSA ]:
275.84000

[ LogP ]:
1.13990

[ 折射率 ]:
1.619

查摸丁卡毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YV9384000

CHEMICAL NAME :: L-Valine, N-(N-(N(sup 2)-L-arginyl-L-lysyl)-L-alpha-aspartyl)-

CAS REGISTRY NUMBER :: 85466-18-8

LAST UPDATED :: 199410

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C21-H40-N8-O7

MOLECULAR WEIGHT :: 516.69

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 11,764,1986

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 11,764,1986

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 11,764,1986