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1-油酰基-2-乙酰基-sn-丙三醇

1-油酰基-2-乙酰基-sn-丙三醇用途

1-油酰-2-乙酰-sn甘油是一种合成的、细胞可渗透的二酰甘油类似物。1-油酰-2-乙酰-sn甘油激活钙依赖性蛋白激酶C(PKC)并诱导超氧化物的产生。

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1-油酰基-2-乙酰基-sn-丙三醇名称

[ CAS 号 ]:
86390-77-4

[ 中文名 ]:
1-油酰基-2-乙酰基-sn-丙三醇

[ 英文名 ]:
1-Oleoyl-2-acetyl-rac-glycerol

[英文别名 ]:

2-Acetoxy-3-hydroxypropyl (9Z)-9-octadecenoate
1-oleoyl-2-acetyl-sn-glycerol
MFCD00166985
1-Oleoyl-2-acetyl-rac-glycerol

1-油酰基-2-乙酰基-sn-丙三醇生物活性

[ 描述 ]:

1-油酰-2-乙酰-sn甘油是一种合成的、细胞可渗透的二酰甘油类似物。1-油酰-2-乙酰-sn甘油激活钙依赖性蛋白激酶C(PKC)并诱导超氧化物的产生。

[ 相关类别 ]:

信号通路 >> 表观遗传学 >> PKC

研究领域 >> 代谢疾病

信号通路 >> TGF-beta/Smad 信号通路 >> PKC

[参考文献]

[1]. Fujita I, Irita K, Takeshige K, Minakami S. Diacylglycerol, 1-oleoyl-2-acetyl-glycerol, stimulates superoxide-generation from human neutrophils. Biochem Biophys Res Commun. 1984;120(2):318-324.

[2]. Martin AC, Cooper DM. Capacitative and 1-oleyl-2-acetyl-sn-glycerol-activated Ca(2+) entry distinguished using adenylyl cyclase type 8. Mol Pharmacol. 2006;70(2):769-777.

1-油酰基-2-乙酰基-sn-丙三醇物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
490.0±15.0 °C at 760 mmHg

[ 分子式 ]:
C₂₃H₄₂O₅

[ 分子量 ]:
398.577

[ 闪点 ]:
152.3±13.9 °C

[ 精确质量 ]:
398.303223

[ PSA ]:
72.83000

[ LogP ]:
7.45

[ 外观性状 ]:
无色油状或蜡质固体

[ 蒸汽压 ]:
0.0±2.8 mmHg at 25°C

[ 折射率 ]:
1.471

[ 储存条件 ]:
−20°C

[ 稳定性 ]:
Temperature Sensitive. This compound can rearrange to the 1,3-isomer in solution or during prolonged storage.

[ 水溶解性 ]:
ethanol: 20 mg/mL

1-油酰基-2-乙酰基-sn-丙三醇安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves

[ 危害码 (欧洲) ]:
F+

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

1-油酰基-2-乙酰基-sn-丙三醇合成路线

详细合成路线

1-油酰基-2-乙酰基-sn-丙三醇文献

Dopaminergic neurotoxicants cause biphasic inhibition of purinergic calcium signaling in astrocytes.

PLoS ONE 9(11) , e110996, (2014)

Dopaminergic nuclei in the basal ganglia are highly sensitive to damage from oxidative stress, inflammation, and environmental neurotoxins. Disruption of adenosine triphosphate (ATP)-dependent calcium...

Calcium sensing receptor modulates extracellular calcium entry and proliferation via TRPC3/6 channels in cultured human mesangial cells.

PLoS ONE 9(6) , e98777, (2014)

Calcium-sensing receptor (CaSR) has been demonstrated to be present in several tissues and cells unrelated to systemic calcium homeostasis, where it regulates a series of diverse cellular functions. A...

A functional tandem between transient receptor potential canonical channels 6 and calcium-dependent chloride channels in human epithelial cells.

Eur. J. Pharmacol. 765 , 337-45, (2015)

TRPC6 plays important human physiological functions, notably in artery and arterioles constriction, in regulation of vascular volume and in bronchial muscle constriction. It is implicated in pulmonary...

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