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2,6-二甲基苯胺

2,6-二甲基苯胺用途

用作农药、医药中间体，用于制造甲霜灵、呋霜灵和利多卡因等

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2,6-二甲基苯胺名称

[ CAS 号 ]:
87-62-7

[ 中文名 ]:
2,6-二甲基苯胺

[ 英文名 ]:
2,6-xylidine

[中文别名 ]:

[英文别名 ]:

o-Xylidine
2-Amino-1,3-xylene
2,6-dimethyl-aniline
Benzene, 2-amino-1,3-dimethyl-
1-amino-2,6-dimethybenzene
Benzenamine,2,6-dimethyl
2,6-xylidine
2,6-dimethylphenylamine
2,6-dimethylbenzeneamine
aniline, 2,6-dimethyl-

2,6-二甲基苯胺物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
217.9±0.0 °C at 760 mmHg

[ 熔点 ]:
10-12 °C(lit.)

[ 分子式 ]:
C₈H₁₁N

[ 分子量 ]:
121.180

[ 闪点 ]:
91.1±0.0 °C

[ 精确质量 ]:
121.089149

[ PSA ]:
26.02000

[ LogP ]:
1.86

[ 外观性状 ]:
无色至微红的黄色液体

[ 蒸汽压 ]:
0.1±0.4 mmHg at 25°C

[ 折射率 ]:
1.559

[ 储存条件 ]:
库房通风低温干燥,与酸类、氧化剂、食品添加剂分开存放

[ 水溶解性 ]:
7.5 g/L (20 ºC)

2,6-二甲基苯胺MSDS

2,6-二甲基苯胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ZE9275000

CHEMICAL NAME :: 2,6-Xylidine

CAS REGISTRY NUMBER :: 87-62-7

BEILSTEIN REFERENCE NO. :: 0636332

LAST UPDATED :: 199710

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C8-H11-N

MOLECULAR WEIGHT :: 121.20

WISWESSER LINE NOTATION :: ZR B1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 840 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - cyanosis Blood - changes in spleen

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 707 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3150 mg/kg/20D-C

TOXIC EFFECTS :: Blood - changes in spleen

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6200 mg/kg/2W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 13300 mg/kg/4W-I

TOXIC EFFECTS :: Liver - other changes Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20150 mg/kg/13W-I

TOXIC EFFECTS :: Brain and Coverings - changes in brain weight Liver - changes in liver weight Blood - changes in other cell count (unspecified)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 107 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Endocrine - tumors

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 301 mg/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,323,1993 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,323,1993 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,323,1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7951 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 4354 (estimated) No. of Female Employees: 729 (estimated)

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2,6-二甲基苯胺安全信息

[ 符号 ]:

GHS07, GHS08, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302 + H312 + H332-H315-H335-H351-H411

[ 警示性声明 ]:
P261-P273-P280

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R20/21/22;R37/38;R40;R51/53

[ 安全声明 (欧洲) ]:
S23-S25-S36/37-S61

[ 危险品运输编码 ]:
UN 1711 6.1/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
ZE9275000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29214910

2,6-二甲基苯胺合成路线

2,6-二甲基苯胺上下游产品

2,6-二甲基苯胺上游产品

2,6-二甲基苯胺下游产品

2,6-二甲基苯胺制备

1.该产品的合成路线主要有2,6-二甲基苯酚氨解法、邻甲基苯胺烷基化法、苯胺甲基化法、间二甲苯双磺化硝化法和间二甲苯硝化还原法等。

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2,6-二甲基苯胺海关

[ 海关编码 ]: 2921430090

[ 中文概述 ]:
2921430090 甲苯胺及其衍生物以及它们的盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 原产地证据文件及编号(例附原产地证书, 原产于欧盟的

[ Summary ]:
HS:2921430090 toluidines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

2,6-二甲基苯胺文献

Simultaneous Determination of Xylazine and 2,6-Xylidine in Blood and Urine by Auto Solid-Phase Extraction and Ultra High Performance Liquid Chromatography Coupled with Quadrupole-Time of Flight Mass Spectrometry.

J. Anal. Toxicol. 39 , 444-50, (2015)

Xylazine as veterinary medicine for sedation, but intoxication cases in humans were identified in the last few years. A highly sensitive method is required for analyzing xylazine and its metabolites i...

A Novel Method for Assessing Drug Degradation Product Safety Using Physiologically-Based Pharmacokinetic Models and Stochastic Risk Assessment.

J. Pharm. Sci. 104 , 3101-19, (2015)

Patient safety risk due to toxic degradation products is a potentially critical quality issue for a small group of useful drug substances. Although the pharmacokinetics of toxic drug degradation produ...

Concentrations of dimethylaniline and other metabolites in milk and tissues of dairy cows treated with lidocaine.

Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 32 , 1256-64, (2015)

Lidocaine is a topical anaesthetic drug used in dairy cows for laparotomy (caesarean section, abomasal displacement). Because there are no registered drugs for this indication, it can be applied under...

更多文献

2,6-二甲基苯胺

2,6-二甲基苯胺用途

2,6-二甲基苯胺名称

2,6-二甲基苯胺物理化学性质

2,6-二甲基苯胺MSDS

详细MSDS(安全技术说明书)

2,6-二甲基苯胺毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

2,6-二甲基苯胺安全信息

2,6-二甲基苯胺合成路线

详细合成路线

2,6-二甲基苯胺上下游产品

2,6-二甲基苯胺上游产品

2,6-二甲基苯胺下游产品

2,6-二甲基苯胺制备

2,6-二甲基苯胺海关

2,6-二甲基苯胺文献

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