1,3-二甲基尿嘧啶

1,3-二甲基尿嘧啶用途

1,3-Dimethyluracil 是由尿嘧啶衍生而来的嘧啶。1,3-Dimethyluracil 偶见于人尿中。1,3-Dimethyluracil 对 hCA I 和 hCA II 有抑制活性,Ki 分别为 316.2 μM 和 166.4 μM。

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1,3-二甲基尿嘧啶名称

[ CAS 号 ]:
874-14-6

[ 中文名 ]:
1,3-二甲基脲嘧啶

[ 英文名 ]:
1,3-Dimethyluracil

[中文别名 ]:

[英文别名 ]:

N1,N3-Dimethyluracil
1,3-dimethylpyrimidine-2,4-dione
2,4(1H,3H)-Pyrimidinedione, 1,3-dimethyl-
1,3-Dimethyl-2,4(1H,3H)-pyrimidinedione
MFCD00038065
1,3-dimethyluracil
Uracil, 1,3-dimethyl-
1,3-dimethylpyrimidine-2,4(1H,3H)-dione
EINECS 212-856-4

1,3-二甲基尿嘧啶生物活性

[ 描述 ]:

1,3-Dimethyluracil 是由尿嘧啶衍生而来的嘧啶。1,3-Dimethyluracil 偶见于人尿中。1,3-Dimethyluracil 对 hCA I 和 hCA II 有抑制活性,Ki 分别为 316.2 μM 和 166.4 μM。

[ 相关类别 ]:

研究领域 >> 代谢疾病

[参考文献]

[1]. Stoessel D, et al. Promising Metabolite Profiles in the Plasma and CSF of Early Clinical Parkinson's Disease. Front Aging Neurosci. 2018 Mar 5;10:51.

[2]. Güney M, et al. Synthesis and carbonic anhydrase inhibitory properties of novel uracil derivatives. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3261-3.

1,3-二甲基尿嘧啶物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
208.4±23.0 °C at 760 mmHg

[ 熔点 ]:
119-122 °C(lit.)

[ 分子式 ]:
C₆H₈N₂O₂

[ 分子量 ]:
140.140

[ 闪点 ]:
84.3±15.0 °C

[ 精确质量 ]:
140.058578

[ PSA ]:
44.00000

[ LogP ]:
0.40

[ 外观性状 ]:
白色至淡黄色针状

[ 蒸汽压 ]:
0.2±0.4 mmHg at 25°C

[ 折射率 ]:
1.519

[ 储存条件 ]:
室温

1,3-二甲基尿嘧啶MSDS

1,3-二甲基尿嘧啶安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36

[ 安全声明 (欧洲) ]:
S22-S24/25-S39-S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2933599090

1,3-二甲基尿嘧啶合成路线

1,3-二甲基尿嘧啶上下游产品

1,3-二甲基尿嘧啶上游产品

1,3-二甲基尿嘧啶下游产品

1,3-二甲基尿嘧啶海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1,3-二甲基尿嘧啶文献

Excited state structures and decay dynamics of 1,3-dimethyluracils in solutions: resonance Raman and quantum mechanical calculation study.

J. Phys. Chem. B 117(39) , 11660-9, (2013)

The resonance Raman spectroscopic study of the excited state structural dynamics of 1,3-dimethyluracil (DMU), 5-bromo-1,3-dimethyluracil (5BrDMU), uracil, and thymine in water and acetonitrile were re...

Ionization of dimethyluracil dimers leads to facile proton transfer in the absence of hydrogen bonds.

Nature Chemistry 4(4) , 323-9, (2012)

Proton transfer is ubiquitous in chemistry and biology, occurring, for example, in proteins, enzyme reactions and across proton channels and pumps. However, it has always been described in the context...

The SO4(.-)-induced chain reaction of 1,3-dimethyluracil with peroxodisulphate.

Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 51(3) , 441-53, (1987)

The sulphate radical SO4(.-) reacts with 1,3-dimethyluracil (1,3-DMU) (k = 5 X 10(9) dm3 mol-1 s-1) thereby forming with greater than or equal to 90 per cent yield the 1,3-DMU C(5)-OH adduct radical 4...

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