5,12-Naphthacenedione,10-[[3-(3-cyano-4-morpholinyl)-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-,(8S,10S)-
名称
[ CAS 号 ]:
88254-07-3
[ 英文名 ]:
5,12-Naphthacenedione,10-[[3-(3-cyano-4-morpholinyl)-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-,(8S,10S)-
[英文别名 ]:
- MRA-CN
- 3'-deamino-3'-(3-cyano-4-morpholinyl)doxorubicin
- cyanomorpholino-doxorubicin
- 3'-Deamino-3'-(3-cyano-4-morpholinyl)adriamycin
物理化学性质
[ 密度 ]:
1.59g/cm3
[ 沸点 ]:
899.2ºC at 760 mmHg
[ 分子式 ]:
C32H34N2O12
[ 分子量 ]:
638.61900
[ 闪点 ]:
497.6ºC
[ 精确质量 ]:
638.21100
[ PSA ]:
216.31000
[ LogP ]:
0.20488
[ 折射率 ]:
1.697
毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QI9405000
- CHEMICAL NAME :
- 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-10-((3-(3-cyanomorpholino)-2,3,6- trideoxy- alpha-L-lyxo-hexopyranosyl)oxy)-8-(hydroxyacetyl)-1-m ethoxy-6,8,11-trihydr oxy-, (8s-cis)-
- CAS REGISTRY NUMBER :
- 88254-07-3
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 16
- MOLECULAR FORMULA :
- C32-H34-N2-O12
- MOLECULAR WEIGHT :
- 638.68
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10 ug/kg
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors
MUTATION DATA
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 30 ng/L
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 44,5599,1984
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CAS号[88254-07-3]化源网提供[5,12-Naphthacenedione,10-[[3-(3-cyano-4-morpholinyl)-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-,(8S,10S)-]MSDS、说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。>>电脑版：5,12-Naphthacenedione,10-[[3-(3-cyano-4-morpholinyl)-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-,(8S,10S)-
标题：88254-07-3_CAS号:88254-07-3_5,12-Naphthacenedione,10-[[3-(3-cyano-4-morpholinyl)-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-,(8S,10S)- - 化源网 地址：https://m.chemsrc.com/mip/cas/88254-07-3_1111633.html