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伯氨喹

伯氨喹用途

伯氨喹是一种有效的抗疟剂,也是恶性疟的有效杀配子细胞剂。伯氨喹预防间日疟和卵形疟复发[1][2]。

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伯氨喹名称

[ CAS 号 ]:
90-34-6

[ 中文名 ]:
伯氨喹

[ 英文名 ]:
Primaquine

[中文别名 ]:

[英文别名 ]:

(±)-Primaquine
[14C]-Primaquine
Primaquine
4-N-(6-methoxyquinolin-8-yl)pentane-1,4-diamine
N4-(6-methoxy-8-quinolinyl)1,4-pentanediamine
Primaquin
Primachinum
1,4-Pentanediamine, N4- (6-methoxy-8-quinolinyl)-
N-(6-Methoxy-8-quinolinyl)-1,4-pentanediamine
1,4-Pentanediamine, N4-(6-methoxy-8-quinolinyl)-

伯氨喹生物活性

[ 描述 ]:

伯氨喹是一种有效的抗疟剂,也是恶性疟的有效杀配子细胞剂。伯氨喹预防间日疟和卵形疟复发[1][2]。

[ 相关类别 ]:

研究领域 >> 感染

[参考文献]

[1]. Baird JK, et al. Primaquine therapy for malaria. Clin Infect Dis. 2004 Nov 1;39(9):1336-45.

[2]. Ashley EA, et al. Primaquine: the risks and the benefits. Malar J. 2014 Nov 3;13:418.

伯氨喹物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
451.1±45.0 °C at 760 mmHg

[ 熔点 ]:
25°C

[ 分子式 ]:
C₁₅H₂₁N₃O

[ 分子量 ]:
259.347

[ 闪点 ]:
226.6±28.7 °C

[ 精确质量 ]:
259.168457

[ PSA ]:
60.17000

[ LogP ]:
2.67

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.616

[ 储存条件 ]:
2-8°C

伯氨喹MSDS

伯氨喹毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VA9650000

CHEMICAL NAME :: Quinoline, 8-(4-amino-1-methylbutylamino)-6-methoxy-

CAS REGISTRY NUMBER :: 90-34-6

BEILSTEIN REFERENCE NO. :: 0019337

LAST UPDATED :: 199712

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C15-H21-N3-O

MOLECULAR WEIGHT :: 259.39

WISWESSER LINE NOTATION :: T66 BNJ HO1 JMY1&3Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15900 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 68800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 96 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 810 mg/kg/3W-I

TOXIC EFFECTS :: Behavioral - ataxia Liver - hepatitis (hepatocellular necrosis), zonal Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 283 mg/kg/5D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 336 mg/kg/16D-I

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 8 mg/kg

REFERENCE :: SYXUD2 Shandong Yixueyuan Xuebao. Journal of Shandong Medical College. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known. Volume(issue)/page/year: 23,26,1985

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伯氨喹安全信息

[ 危害码 (欧洲) ]:
Xn

[ 海关编码 ]:
2933499090

伯氨喹合成路线

伯氨喹上下游产品

伯氨喹上游产品

伯氨喹下游产品

伯氨喹海关

[ 海关编码 ]: 2933499090

[ 中文概述 ]:
2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

伯氨喹