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α-葡萄糖苷酶

α-葡萄糖苷酶用途

α-葡萄糖苷酶(α-D-葡萄糖苷酶)是一种碳水化合物水解酶,催化α-葡萄糖从底物的非还原端释放。α-葡萄糖苷酶可促进小肠对葡萄糖的吸收。抑制α-葡萄糖苷酶是治疗非胰岛素依赖型糖尿病(NIDDM)的有效方法[1][2]。

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α-葡萄糖苷酶名称

[ CAS 号 ]:
9001-42-7

[ 中文名 ]:
α-葡萄糖苷酶

[ 英文名 ]:
α-Glucosidase

[英文别名 ]:

EINECS 232-604-7
MFCD00081321

α-葡萄糖苷酶生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[体内研究]

α-葡萄糖苷酶是存在于小肠上皮中的一种膜结合酶,其作用是通过催化低聚糖水解裂解为可吸收的葡萄糖,促进小肠对葡萄糖的吸收。抑制α-葡萄糖苷酶可减缓碳水化合物餐后血糖的升高[1]。

[参考文献]

[1]. Kumar S, et, al. α-glucosidase inhibitors from plants: A natural approach to treat diabetes. Pharmacogn Rev. 2011 Jan;5(9):19-29.

[2]. Laar FA, et, al. Alpha-glucosidase inhibitors for patients with type 2 diabetes: results from a Cochrane systematic review and meta-analysis. Diabetes Care. 2005 Jan;28(1):154-63.

α-葡萄糖苷酶物理化学性质

[ 外观性状 ]:
powder | off-white

[ 储存条件 ]:
2-8°C

α-葡萄糖苷酶安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

α-葡萄糖苷酶制备

大麦在控制条件下发芽至麦粒长径的1.5倍左右时取出，此为“绿麦芽”，水分约40%～45%，经打浆、过滤等处理后即得液体制剂。如发芽后用50～60℃气流干燥至含水13%～15%，是为风烹品。如进一步干燥至含水量3%～4%，则为干麦芽，用此磨粉过筛后即为粉状制剂。绿麦芽的糖化力

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α-葡萄糖苷酶文献

In vitro and in vivo effects of standardized extract and fractions of Phaleria macrocarpa fruits pericarp on lead carbohydrate digesting enzymes.

BMC Complement Altern. Med. 13 , 39, (2013)

One vital therapeutic approach for the treatment of type 2 diabetes mellitus is the use of agents that can decrease postprandial hyperglycaemia by inhibiting carbohydrate digesting enzymes. The presen...

Enzymatic properties of a thermostable α-glucosidase from acidothermophilic crenarchaeon Sulfolobus tokodaii strain 7.

J. Microbiol. Biotechnol. 23(1) , 56-63, (2013)

We have characterized the putative α-glucosidase gene (st2525) selected by total genome analysis from the acidothermophilic crenarchaeon Sulfolobus tokodaii strain 7. The ORF was cloned and expressed ...

Identification of the first deletion-insertion involving the complete structure of GAA gene and part of CCDC40 gene mediated by an Alu element.

Gene 519(1) , 169-72, (2013)

Pompe disease is an uncommon autosomal recessive glycogen storage disorder caused by deficiency of acid α-glucosidase. Classic infantile form triggers severe cardiomyopathy, hypotonia, and respiratory...

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