链激酶

链激酶是一种细菌衍生的蛋白质和纤溶酶原激活剂。链激酶被广泛用于研究凝血障碍。链激酶改善冠状动脉阻塞后的再灌注血流[1][2]。

[ 描述 ]:

[ 相关类别 ]:

[体内研究]

[参考文献]

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
343.9±35.0 °C at 760 mmHg

[ 分子式 ]:
C₁₁H₁₉NO₂

[ 分子量 ]:
197.274

[ 闪点 ]:
161.8±25.9 °C

[ 精确质量 ]:
197.141586

[ PSA ]:
49.33000

[ LogP ]:
1.99

[ 外观性状 ]:
lyophilized powder

[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C

[ 折射率 ]:
1.517

[ 储存条件 ]:
−20°C

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :

OB8880000

CHEMICAL NAME :

Kinase (enzyme-activating), strepto-

CAS REGISTRY NUMBER :

9002-01-1

LAST UPDATED :

199512

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Human

DOSE/DURATION :

600 iu/kg

TOXIC EFFECTS :

Immunological Including Allergic - uncharacterized

REFERENCE :

JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 252,1314,1984

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Human - man

DOSE/DURATION :

562500 iu/kg

TOXIC EFFECTS :

Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Lungs, Thorax, or Respiration - dyspnea

REFERENCE :

JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 252,1314,1984

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

2 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,671,1980

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

>10 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

FOHEAW Folia Haematologica (Leipzig). (Buchexport, Postfach 160, Leipzig DDR-7010, Ger. Dem. Rep.) V.32- 1926- Volume(issue)/page/year: 103,445,1976

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

4200 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

FOHEAW Folia Haematologica (Leipzig). (Buchexport, Postfach 160, Leipzig DDR-7010, Ger. Dem. Rep.) V.32- 1926- Volume(issue)/page/year: 103,445,1976

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

3700 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,671,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4087 No. of Facilities: 41 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 9366 (estimated) No. of Female Employees: 8266 (estimated)

[ 危害码 (欧洲) ]:
C,Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
22-24/25-36-26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
OB8880000

Staphylokinase, a fibrin-specific plasminogen activator with therapeutic potential?

Blood 84 , 680-6, (1994)

Primary coronary intervention versus thrombolytic therapy in myocardial infarction patients in the Middle East Al-Zakwani, I., et al.

J. Am. Med. Assoc. 34(3) , 445-51, (2012)

Effects of plasminogen and streptokinase on the vital functions of nervous tissue cells in culture Nikandrov, V., et al.

Biomed. Khim. 54 , 192-200, (2012)

更多文献

公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥需询单/1mg

联系人：刘佳

产品详情：链激酶

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