3,3′-二氯联苯胺
3,3′-二氯联苯胺用途
用作染料、颜料中间体
3,3′-二氯联苯胺名称
[ CAS 号 ]:
91-94-1
[ 中文名 ]:
3,3′-二氯联苯胺
[ 英文名 ]:
3,3'-Dichlorobenzidine
[中文别名 ]:
[英文别名 ]:
- DCB
- ortho,ortho'-Dichlorobenzidine
- Dichlorobenzidine, 3,3'-
- 3,3'-Dichlorobenzidine
- 3,3'-Dichloro-4,4'-diamino(1,1-biphenyl)
- 3,3'-Dichloro-4,4'-biphenyldiamine
- [1,1'-Biphenyl]-4,4'-diamine, 3,3'-dichloro-
- 3,3'-Dichloro-(1,1'-biphenyl)-4,4'-diamine
- 4-13-00-00384 (Beilstein Handbook Reference)
- 3,3`-dichlorobenzidine
3,3′-二氯联苯胺物理化学性质
[ 密度 ]:
1.4±0.1 g/cm3
[ 沸点 ]:
385.0±37.0 °C at 760 mmHg
[ 熔点 ]:
133ºC
[ 分子式 ]:
C12H10Cl2N2
[ 分子量 ]:
253.127
[ 闪点 ]:
186.6±26.5 °C
[ 精确质量 ]:
252.022110
[ PSA ]:
52.04000
[ LogP ]:
3.45
[ 外观性状 ]:
灰色至紫色结晶粉末
[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C
[ 折射率 ]:
1.679
[ 储存条件 ]:
库房通风低温干燥,与氧化剂,食品分开储运
[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.
3,3′-二氯联苯胺MSDS
3,3′-二氯联苯胺毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DD0525000
- CHEMICAL NAME :
- Benzidine, 3,3'-dichloro-
- CAS REGISTRY NUMBER :
- 91-94-1
- BEILSTEIN REFERENCE NO. :
- 2108022
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 53
- MOLECULAR FORMULA :
- C12-H10-Cl2-N2
- MOLECULAR WEIGHT :
- 253.14
- WISWESSER LINE NOTATION :
- ZR BG DR DZ CG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 17 gm/kg/50W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Blood - tumors Skin and Appendages - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3600 mg/kg/61W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - breast
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5100 mg/kg/43W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 320 mg/kg female 15-21 day(s) after conception
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Reproductive - Tumorigenic effects - transplacental tumorigenesis Lungs, Thorax, or Respiration - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5200 mg/kg/47W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 17 gm/kg/7Y-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - hamster
- DOSE/DURATION :
- 176 gm/kg/70W-C
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 20 gm/kg/52W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Skin and Appendages - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 21 gm/kg/50W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Blood - tumors Skin and Appendages - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 7 gm/kg/43W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TYPE OF TEST :
- Cytogenetic analysis
MUTATION DATA
- TYPE OF TEST :
- DNA adduct
- TEST SYSTEM :
- Mammal - species unspecified Lymphocyte
- REFERENCE :
- CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 38,369,1982 *** REVIEWS *** ACGIH TLV-Animal carcinogen, NO TWA (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 4,49,1974 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 29,239,1982 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 29,239,1982 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,193,1987 TOXICOLOGY REVIEW ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1- 1950- Volume(issue)/page/year: 13,271,1970 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD:skin-HUMAN CARCINOGEN, NO ASSIGNED TWA DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,77,1971 OSHA PEL (Gen Indu):see CFR 29,1910.1007 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):see CFR 29,1926.1107 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):see CFR 29,1915.1007 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA-cancer suspect agent CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1007,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA;Skin;Carcinogen JAN 1993 OEL-FRANCE;Carcinogen JAN 1993 OEL-GERMANY;Skin;Carcinogen JAN 1993 OEL-SWEDEN;Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 0.1 mg/m3;Skin;Carcinogen JAN 1993 OEL-SWITZERLAND;Carcinogen JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 3,3'-DICHLOROBENZIDINE-air:CA use 29 CFR 1910.1007 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992
3,3′-二氯联苯胺安全信息
[ 符号 ]:
GHS02, GHS06, GHS08, GHS09
[ 信号词 ]:
Danger
[ 危害声明 ]:
H225-H301 + H311 + H331-H350-H370-H411
[ 警示性声明 ]:
P201-P210-P260-P273-P280-P301 + P310
[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ 危害码 (欧洲) ]:
T,N,F
[ 风险声明 (欧洲) ]:
R45
[ 安全声明 (欧洲) ]:
S53-S45-S60-S61-S36/37-S16-S7
[ 危险品运输编码 ]:
UN 3077 9/PG 3
[ WGK德国 ]:
3
[ RTECS号 ]:
DD0550000
[ 包装等级 ]:
II
[ 危险类别 ]:
6.1
[ 海关编码 ]:
2921590032
3,3′-二氯联苯胺合成路线
3,3′-二氯联苯胺上下游产品
3,3′-二氯联苯胺上游产品
3,3′-二氯联苯胺下游产品
3,3′-二氯联苯胺制备
将邻硝基氯苯用锌在碱性条件下偶联还原，然后在酸性条件使还原产物发生重排得到3,3’-二氯联苯胺盐酸盐。
3,3′-二氯联苯胺海关
[ 海关编码 ]: 2921590032
[ 中文概述 ]:
HS:2921590032 3,3’-二氯联苯胺 增值税率:17.0% 退税率:9.0% 监管条件:X 最低关税:6.5% 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ 监管条件 ]: X.有毒化学品环境管理放行通知单
[ Summary ]:
HS:2921590032 3,3'-dichloro-[1,1'-biphenyl]-4,4'-diamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:x MFN tariff:6.5% General tariff:30.0%
3,3′-二氯联苯胺文献
Environ. Mol. Mutagen. 48(5) , 404-13, (2007)
4-Aminobyphenyl (4-Ab), benzidine (Bz), and Bz congeners were evaluated for their ability to induce genotoxicity through an oxidative mechanism. The mutagenicity of these compounds was tested in the p...
Photodechlorination of 3,3'-dichlorobenzidine in water.Environ. Toxicol. Chem. 21(3) , 500-6, (2002)
Laboratory experiments have been conducted to elucidate the photochemical behavior of 3,3'-dichlorobenzidine (DCB) and its congeners in aquatic systems. Photodechlorination of DCB was observed in aque...
Determination of dichlorobenzidine-hemoglobin adducts by GC/MS-NCI.Int. Arch. Occup. Environ. Health 69(4) , 240-6, (1997)
A method based on gas chromatography/mass spectrometry-negative ion chemical ionization detection (GC/MS-NCI) was developed for the determination of 3,3'-dichlorobenzidine (DCB)-hemoglobin adducts. Ad...
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价格：
￥1148.0/100mg
联系人：刘佳
产品详情：3,3-二氯联苯胺
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥1129.0/100mg
￥需询单/1g
￥需询单/1g
￥需询单/1g
联系人：阿拉丁
产品详情：3,3-二氯联苯胺
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