邻氯硝基苯
邻氯硝基苯用途
邻硝基氯苯是重要的有机合成中间体，可衍生多种中间体。在染料工业中用于制黄色基GC，橙色基GR等； 在助剂方面用于制造橡胶促进剂M及DM等；在香料工业中用于香草醛的合成；农药工业用于生产托布津和甲基托布津、多菌灵；它也是苯并三氮唑类紫外线吸收剂的原料。也是医药的重要中间体。
邻氯硝基苯名称
[ CAS 号 ]:
88-73-3
[ 中文名 ]:
邻氯硝基苯
[ 英文名 ]:
2-Nitrochlorobenzene
[中文别名 ]:
[英文别名 ]:
- 2-Nitrochlorobenzene
- 1-Chloro-2-nitro-benzene
- ortho-chloronitrobenzene
- 1-Nitro-2-chlorobenzene
- benzene, chloronitro-
- chloronitrobenzene
- MFCD00007061
- EINECS 201-854-9
- nitrochlorobenzene
- Nitrochlorobenzene, o-
邻氯硝基苯物理化学性质
[ 密度 ]:
1.4±0.1 g/cm3
[ 沸点 ]:
245.5±0.0 °C at 760 mmHg
[ 熔点 ]:
31-33 °C(lit.)
[ 分子式 ]:
C6H4ClNO2
[ 分子量 ]:
157.555
[ 闪点 ]:
96.5±19.8 °C
[ 精确质量 ]:
156.993057
[ PSA ]:
45.82000
[ LogP ]:
2.34
[ 外观性状 ]:
淡黄色至黄色铸铁或油性液体
[ 蒸汽密度 ]:
5.4 (vs air)
[ 蒸汽压 ]:
0.0±0.4 mmHg at 25°C
[ 折射率 ]:
1.580
[ 储存条件 ]:
库房通风低温干燥,与氧化剂、食品添加剂分开存放
[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents, reducing agents, strong bases, alkali metals.
[ 水溶解性 ]:
0.43 g/L (20 ºC)
邻氯硝基苯MSDS
邻氯硝基苯毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- CZ0875000
- CHEMICAL NAME :
- Benzene, 1-chloro-2-nitro-
- CAS REGISTRY NUMBER :
- 88-73-3
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 26
- MOLECULAR FORMULA :
- C6-H4-Cl-N-O2
- MOLECULAR WEIGHT :
- 157.56
- WISWESSER LINE NOTATION :
- WNR BG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 268 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 135 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 280 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 30 mg/m3/6H/4W-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Endocrine - changes in spleen weight Blood - methemoglobinemia-carboxyhemoglobin
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4500 ppb/6H/13W-C
- TOXIC EFFECTS :
- Liver - changes in liver weight Blood - methemoglobinemia-carboxyhemoglobin Blood - changes in erythrocyte (RBC) count
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 18 ppm/6H/2W-C
- TOXIC EFFECTS :
- Liver - hepatitis (hepatocellular necrosis), zonal Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in spleen weight
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2300 ppb/6H/13W-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 22 gm/kg/78W-C
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors Endocrine - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 140 gm/kg/78W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 280 gm/kg/78W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- DOSE :
- 18 ppm/6H
- SEX/DURATION :
- male 13 week(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- DOSE :
- 4500 ppb/6H
- SEX/DURATION :
- male 13 week(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 100 ug/plate
- REFERENCE :
- ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 5(Suppl 1),3,1983 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 65,263,1996 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 65,263,1996 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 65,263,1996 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-POLAND:TWA 1 mg/m3 JAN 1993 OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4011 No. of Facilities: 42 (estimated) No. of Industries: 3 No. of Occupations: 5 No. of Employees: 2897 (estimated) No. of Female Employees: 662 (estimated)
邻氯硝基苯安全信息
[ 符号 ]:
GHS06
[ 信号词 ]:
Danger
[ 危害声明 ]:
H301 + H311
[ 警示性声明 ]:
P280-P301 + P310-P312
[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
[ 危害码 (欧洲) ]:
T:Toxic;
[ 风险声明 (欧洲) ]:
R22;R24;R52/53
[ 安全声明 (欧洲) ]:
S36/37/39-S45-S60-S38-S28A
[ 危险品运输编码 ]:
UN 1578 6.1/PG 2
[ WGK德国 ]:
2
[ RTECS号 ]:
CZ0875000
[ 包装等级 ]:
II
[ 危险类别 ]:
6.1
[ 海关编码 ]:
29049085
邻氯硝基苯合成路线
邻氯硝基苯上下游产品
邻氯硝基苯上游产品
邻氯硝基苯下游产品
邻氯硝基苯制备
由氯苯经混酸硝化，得到混合硝基氯苯。三种异构体的含量大体是：对硝基氯苯占65%，邻硝基氯苯占30%，间硝基氯苯占1%。工艺过程如下：先将配制好的混酸（含硝酸30%，硫酸56%，水14%）加入硝化锅内。维持温度40-55℃下，慢慢加入氯苯，加毕升温至80℃，搅拌反应2h。静置分层，将上层混合硝基氯苯用水洗、碱洗，水洗后静置分出，于真空加热至100℃干燥，得混合硝基氯苯。然后在结晶器内，将上述干燥后的混合硝基氯苯逐渐降温到15℃，即有大量的对硝基氯苯集于管壁，经加热熔化，收入贮槽，真空精馏，除去氯苯后即得对硝基氯苯。从结晶器下部放出的母液内含对硝基氯苯约35%，邻硝基氯苯64%及少量间硝基氯苯，供进一步分离。将此物精馏分出的粗邻硝基氯苯，再于结晶器内，采用降低结晶器内温度到15℃使之结晶的办法，即得成品。原料消耗定额：对硝基氯苯、氯苯1150kg/t、硝酸672kg/t、硫酸（92.5%）632kg/t。
邻氯硝基苯海关
[ 海关编码 ]: 2904901100
[ 中文概述 ]:
2904901100 邻硝基氯化苯。监管条件:无。增值税率:17.0%。退税率:9.0%。最低关税:5.5%。普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2904901100 1-chloro-2-nitrobenzene. Supervision conditions:None.VAT:17.0% Tax rebate rate:9.0%
邻氯硝基苯文献
Arch. Dermatol. 124(3) , 396-8, (1988)
2,4-Dinitrochlorobenzene (DNCB) is used for immunotherapy of alopecia areata and verruca vulgaris. We initially postulated that the presence of mutagenic contaminants in commercially available DNCB mi...
Determination of trace level genotoxic impurities in small molecule drug substances using conventional headspace gas chromatography with contemporary ionic liquid diluents and electron capture detection.J. Chromatogr. A. 1361 , 217-28, (2014)
Ionic liquids (ILs) were used as a new class of diluents for the analysis of two classes of genotoxic impurities (GTIs), namely, alkyl/aryl halides and nitro-aromatics, in small molecule drug substanc...
2-Chloronitrobenzene, 3-chloronitrobenzene and 4-chloronitrobenzene.IARC Monogr. Eval. Carcinog. Risks Hum. 65 , 263-96, (1996)
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价格：
￥178.0/500g
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产品详情：邻氯硝基苯
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区域：上海市浦东新区
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相关化合物
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