4-苯基苯酚

4-苯基苯酚用途

【用途一】
用于制油溶性树脂和乳化剂，用作耐腐蚀漆的组分、印染的载体等
【用途二】
联苯酚又称对苯基苯酚，是杀菌剂联苯三唑醇的中间体。
【用途三】
作防腐杀菌剂，我国规定可用于柑橘保鲜，最大使用量为1.0g/kg，残留量不大于12mg/kg。
【用途四】
用作染料、树脂和橡胶的中间体。该品合成的红光增感、绿光增感染料是彩色影片的主要原料之一，也用作分析试剂。
【用途五】
用于农药和感光染料的合成，以及高分子液晶单体的合成。树脂和橡胶中间体。该品合成红光增感，绿光增感染料是彩色影片的主要原料之一，也用作分析试剂。

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4-苯基苯酚名称

[ CAS 号 ]:
92-69-3

[ 中文名 ]:
对苯基苯酚

[ 英文名 ]:
4-Biphenylol

[中文别名 ]:

[英文别名 ]:

P-PHENYLPHENOL
p-hydroxybiphenyl
1, 4-PHENYLPHENOL
4-Biphenylol
[1,1'-Biphenyl]-4-ol
Hydroxy diphenyl
tetrosinp300
4-PHENYLPHENOL/BIPHENYL-4-OL/4-HYDROXYBIPHENYL
PARAXENOL
4-PHENYL PHENOL

4-苯基苯酚物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
306.4±11.0 °C at 760 mmHg

[ 熔点 ]:
164-166 °C(lit.)

[ 分子式 ]:
C₁₂H₁₀O

[ 分子量 ]:
170.207

[ 闪点 ]:
165.6±0.0 °C

[ 精确质量 ]:
170.073166

[ PSA ]:
20.23000

[ LogP ]:
3.20

[ 外观性状 ]:
几乎白色晶体

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.605

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents, strong bases, halogens. Combustible.

[ 水溶解性 ]:
0.7 g/L (20 ºC)

4-苯基苯酚MSDS

详细MSDS(安全技术说明书)

4-苯基苯酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DV5850000

CHEMICAL NAME :: 4-Biphenylol

CAS REGISTRY NUMBER :: 92-69-3

LAST UPDATED :: 199710

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C12-H10-O

MOLECULAR WEIGHT :: 170.22

WISWESSER LINE NOTATION :: QR DR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 153 gm/kg/78W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - leukemia

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB223-159

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1000 mg/kg

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Blood - tumors

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB223-159 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84022 No. of Facilities: 5 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 20 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84022 No. of Facilities: 216 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 649 (estimated)

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4-苯基苯酚安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H411

[ 警示性声明 ]:
P273

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R38;R51/53

[ 安全声明 (欧洲) ]:
S26-S36/37-S61-S36

[ 危险品运输编码 ]:
UN3077

[ WGK德国 ]:
2

[ RTECS号 ]:
DV5850000

[ 包装等级 ]:
III

[ 危险类别 ]:
9

[ 海关编码 ]:
29071900

4-苯基苯酚合成路线

详细合成路线

4-苯基苯酚上下游产品

4-苯基苯酚上游产品

4-苯基苯酚下游产品

4-苯基苯酚制备

【方法一】
磺化法生产苯酚的蒸馏残渣中约含40%的混位(对位和邻位)苯基苯酚，用分馏和在三氯乙烯中溶解度的不同，分离回收对位产品。参见2-苯基苯酚钠盐(17020)。
【方法二】
其制备方法有两种。
磺化法生产苯酚的副产物分离
用磺化法生产苯酚的副产物蒸馏，残渣中含对苯基苯酚和邻苯基苯酚，先将该残渣加热，经真空蒸馏，真空度控制在53.3～66.7kPa，温度由65～75℃逐渐上升到100℃以上，但不超过135℃，再利用邻、对位苯基苯酚在三氯乙烯中的溶解度不同进行分离，即将该混合苯基苯酚加热溶于三氯乙烯中，经冷却析出对位苯基苯酚结晶，过滤干燥即得产品。
联苯磺化碱熔法
将联苯溶于乙酸中，用三氧化硫进行磺化，磺化产物分离后与20％NaOH水溶液作用成盐，再和固体NaOH在100～350℃碱熔，然后进行酸化得产品。
【方法三】
可从磺化法生产苯酚的蒸馏残渣中回收。

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4-苯基苯酚海关

[ 海关编码 ]: 2907199090

[ 中文概述 ]:
2907199090 其他一元酚. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2907199090 other monophenols VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

4-苯基苯酚文献

Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.

J. Med. Chem. 48 , 5666-74, (2005)

We investigated the influence of induced fit of the androgen receptor binding pocket on free energies of ligand binding. On the basis of a novel alignment procedure using flexible docking, molecular d...

Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach.

J. Med. Chem. 48 , 2469-79, (2005)

A novel class of 2-(R)-phenylpropionamides has been recently reported to inhibit in vitro and in vivo interleukin-8 (CXCL8)-induced biological activities. These CXCL8 inhibitors are derivatives of phe...

Influences of exogenous probiotics and tea polyphenols on the production of three acids during the simulated colonic fermentation of maize resistant starch.

J. Food Sci. Technol. 52 , 5874-81, (2015)

In the present study, influences of nine probiotics and tea polyphenols on the production of acetic, butyric, and lactic acid from simulated colonic fermentation of maize resistant starch (RS) were in...

更多文献

4-苯基苯酚

4-苯基苯酚用途

4-苯基苯酚名称

4-苯基苯酚物理化学性质

4-苯基苯酚MSDS

详细MSDS(安全技术说明书)

4-苯基苯酚毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

4-苯基苯酚安全信息

4-苯基苯酚合成路线

详细合成路线

4-苯基苯酚上下游产品

4-苯基苯酚上游产品

4-苯基苯酚下游产品

4-苯基苯酚制备

4-苯基苯酚海关

4-苯基苯酚文献

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