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2-羟基-3-萘甲酸

2-羟基-3-萘甲酸用途

主要用于制造色酚AS及其他各种色酚的中间体，也可作医药及有机颜料的中间体

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2-羟基-3-萘甲酸名称

[ CAS 号 ]:
92-70-6

[ 中文名 ]:
2-羟基-3-萘甲酸

[ 英文名 ]:
3-Hydroxy-2-naphthoic acid

[中文别名 ]:

[英文别名 ]:

3-Hydroxy-2-naphthoic acid
3-hydroxynaphthalene-2-carboxylic acid
EINECS 202-180-8
MFCD00004103
2-Naphthalenecarboxylic acid, 3-hydroxy-

2-羟基-3-萘甲酸物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
367.7±25.0 °C at 760 mmHg

[ 熔点 ]:
218-221 °C(lit.)

[ 分子式 ]:
C₁₁H₈O₃

[ 分子量 ]:
188.179

[ 闪点 ]:
190.4±19.7 °C

[ 精确质量 ]:
188.047348

[ PSA ]:
57.53000

[ LogP ]:
3.29

[ 外观性状 ]:
淡黄色粉末

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.716

[ 储存条件 ]:
室温

[ 水溶解性 ]:
PRACTICALLY INSOLUBLE

2-羟基-3-萘甲酸MSDS

2-羟基-3-萘甲酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QL1755000

CHEMICAL NAME :: 2-Naphthoic acid, 3-hydroxy-

CAS REGISTRY NUMBER :: 92-70-6

BEILSTEIN REFERENCE NO. :: 0744100

LAST UPDATED :: 199710

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C11-H8-O3

MOLECULAR WEIGHT :: 188.19

WISWESSER LINE NOTATION :: L66J CQ DVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 832 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533749

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533574

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 376 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 176,193,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,663,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533574

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 783 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533574

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533574 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83636 No. of Facilities: 49 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 1414 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83636 No. of Facilities: 27 (estimated) No. of Industries: 2 No. of Occupations: 17 No. of Employees: 1639 (estimated)

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2-羟基-3-萘甲酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
QL1755000

[ 海关编码 ]:
29182910

2-羟基-3-萘甲酸合成路线

2-羟基-3-萘甲酸上下游产品

2-羟基-3-萘甲酸上游产品

2-羟基-3-萘甲酸下游产品

2-羟基-3-萘甲酸制备

β-萘酚与氢氧化钠成盐后，加热减压脱水，得到的无水β-萘酚盐与二氧化碳发生羧基化，生产2,3酸双钠盐，再用硫酸酸化得成品。

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2-羟基-3-萘甲酸海关

[ 海关编码 ]: 2918290000

[ 中文概述 ]:
2918290000 其他含酚基但不含其他含氧基羧酸及其酸酐、酰卤化物、过氧化物和过氧酸及它们的衍生物。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

2-羟基-3-萘甲酸文献

Mono- and disalicylic acid derivatives: PTP1B inhibitors as potential anti-obesity drugs.

Bioorg. Med. Chem. 15 , 6535-48, (2007)

A series of compounds containing one or two salicylic acid moieties were synthesized, and their efficacy to inhibit the phosphohydrolase activity of PTP1B examined. Some of the methylenedisalicylic ac...

Coupling solid-phase microextraction and laser desorption ionization for rapid identification of biological material.

Rapid Commun. Mass Spectrom. 26 , 853-862, (2012)

Solid phase microextraction (SPME) use small fibers directly plunged in the solution under investigation to quickly extract and quantify by different techniques the amount of selected dissolved compou...

Hydrazide and hydrazine reagents as reactive matrices for MALDI-MS to detect gaseous aldehydes.

J. Mass Spectrom. 49(8) , 742-9, (2014)

The reagents 19 hydrazide and 14 hydrazine were examined to function as reactive matrices for matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) to detect gaseous aldehydes. Amon...

更多文献

2-羟基-3-萘甲酸

2-羟基-3-萘甲酸用途

2-羟基-3-萘甲酸名称

2-羟基-3-萘甲酸物理化学性质

2-羟基-3-萘甲酸MSDS

详细MSDS(安全技术说明书)

2-羟基-3-萘甲酸毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

2-羟基-3-萘甲酸安全信息

2-羟基-3-萘甲酸合成路线

详细合成路线

2-羟基-3-萘甲酸上下游产品

2-羟基-3-萘甲酸上游产品

2-羟基-3-萘甲酸下游产品

2-羟基-3-萘甲酸制备

2-羟基-3-萘甲酸海关

2-羟基-3-萘甲酸文献

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