2-萘酚
2-萘酚用途
用于制吐氏酸、J酸、2,3酸以及偶氮染料,也是橡胶防老剂、选矿剂、杀菌剂、防霉剂、防腐剂等的原料
【用途二】
用作分析试剂、乙烯、一氧化碳吸收剂及荧光指示剂
【用途三】
作防腐剂,我国规定可用于柑橘保鲜,最大使用量为0.1g/kg,残留量不大于70mg/kg。
【用途四】
用作饲料防腐剂,我国规定还可用于柑橘保鲜,最大使用量为0.1g/kg,残留量不大于70mg/kg。
【用途五】
乙萘酚又称β-萘酚、2-萘酚,是植物生长调节剂萘氧乙酸的中间体。
【用途六】
重要的有机原料及染料中间体,用于制造吐氏酸、丁酸、β-萘酚-3-甲酸,并用于制造防老剂丁、防老剂DNP及其他防老剂、有机颜料及杀菌剂等。
【用途七】
溴、氯、氯酸盐、铌、铜、亚硝酸盐和钾的检定。酚磺转移酶的荧光测定底物。酸碱指示剂, 染料, 有机合成, 烯丙醇、甲醇、氯仿等的定性测定。一氧化碳、乙醇吸收剂,荧光指示剂。
2-萘酚名称
[ CAS 号 ]:
135-19-3
[ 中文名 ]:
β-萘酚
[ 英文名 ]:
2-Naphthol
[中文别名 ]:
[英文别名 ]:
- β-naphthol
- β-Naphthyl alcohol
- 2-Naphthalenol
- β-hydroxynaphthalene
- Betanaphthol
- EINECS 205-182-7
- Naphthol B
- 2-Hydroxynaphthalene
- b-Naphthol
- Isonaphthol
2-萘酚生物活性
[ 描述 ]:
[ 相关类别 ]:
[ 靶点 ]
Human Endogenous Metabolite
[体外研究]
[参考文献]
[相关活性小分子]
2-萘酚物理化学性质
[ 密度 ]:
1.2±0.1 g/cm3
[ 沸点 ]:
285.5±0.0 °C at 760 mmHg
[ 熔点 ]:
120-122 °C(lit.)
[ 分子式 ]:
C10H8O
[ 分子量 ]:
144.170
[ 闪点 ]:
144.0±10.6 °C
[ 精确质量 ]:
144.057510
[ PSA ]:
20.23000
[ LogP ]:
2.71
[ 外观性状 ]:
裂纹白有光泽的片或白色粉末
[ 蒸汽密度 ]:
4.97 (vs air)
[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C
[ 折射率 ]:
1.678
[ 储存条件 ]:
Refrigerator
[ 稳定性 ]:
Stable. Combustible. Dust may form explosive mixture with air. Incompatible with strong oxidizing agents, phenol.
[ 水溶解性 ]:
1 g/L (20 ºC)
2-萘酚MSDS
2-萘酚毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QL2975000
- CHEMICAL NAME :
- 2-Naphthol
- CAS REGISTRY NUMBER :
- 135-19-3
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 30
- MOLECULAR FORMULA :
- C10-H8-O
- MOLECULAR WEIGHT :
- 144.18
- WISWESSER LINE NOTATION :
- L66J CQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1960 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >770 mg/m3/1H
- TOXIC EFFECTS :
- Gastrointestinal - changes in structure or function of salivary glands
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2940 mg/kg
- TOXIC EFFECTS :
- Behavioral - sleep Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 97500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 3800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 3 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 3800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 1335 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 2670 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10080 mg/kg/28D-C
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 107 mg/kg/35W-I
- TOXIC EFFECTS :
- Brain and Coverings - other degenerative changes Behavioral - alteration of classical conditioning
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1350 ug/m3/17W-I
- TOXIC EFFECTS :
- Blood - changes in erythrocyte (RBC) count Blood - changes in leukocyte (WBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other esterases
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 298 mg/kg/35W-I
- TOXIC EFFECTS :
- Liver - liver function tests impaired
MUTATION DATA
- TYPE OF TEST :
- DNA repair
- TEST SYSTEM :
- Bacteria - Bacillus subtilis
- DOSE/DURATION :
- 5 gm/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 42,19,1977 *** REVIEWS *** TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 47,75,1978 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.1 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84296 No. of Facilities: 971 (estimated) No. of Industries: 18 No. of Occupations: 18 No. of Employees: 6346 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1957 No. of Facilities: 113 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 453 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84296 No. of Facilities: 199 (estimated) No. of Industries: 11 No. of Occupations: 26 No. of Employees: 10985 (estimated) No. of Female Employees: 590 (estimated)
2-萘酚安全信息
[ 符号 ]:
GHS07, GHS09
[ 信号词 ]:
Warning
[ 危害声明 ]:
H302 + H332-H400
[ 警示性声明 ]:
P273
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves
[ 危害码 (欧洲) ]:
Xn:Harmful
[ 风险声明 (欧洲) ]:
R20/22;R50
[ 安全声明 (欧洲) ]:
S24/25-S61
[ 危险品运输编码 ]:
UN 3077 9/PG 3
[ WGK德国 ]:
2
[ RTECS号 ]:
QL2975000
[ 包装等级 ]:
III
[ 危险类别 ]:
9
[ 海关编码 ]:
2907151000
2-萘酚合成路线
2-萘酚上下游产品
2-萘酚上游产品
2-萘酚下游产品
2-萘酚制备
其制备方法是在140℃将硫酸加入熔融萘中,在162~164℃进行磺化,将磺化物水解,吹去游离萘,用亚硫酸钠与其反应使生成2-萘磺酸钠盐,该钠盐固体和氢氧化钠于285~320℃进行碱熔,然后在320~330℃保温1h,将碱熔物稀释后通入二氧化硫进行酸化得粗制品,洗涤脱水后蒸馏而得产品。
【方法二】
磺化碱熔法
将精萘置于磺化锅,加热(熔融)至140℃。在20min内加入1.085倍(摩尔比)浓硫酸,升温,并在160~164℃下保温2.5h。当2-萘磺酸含量达66%以上、总酸度为25%~27%时结束反应。磺化物于水解锅中在140~150℃下水解1h。然后在中和锅中,在80~90℃下用亚硫酸氢钠溶液中和至刚果红试纸不变蓝为止。用蒸汽和空气驱除SO2气体,降温至30~40℃后吸滤,并用10%的食盐水洗涤后再吸滤得2-萘磺酸钠。
将氢氧化钠置于碱熔锅中,加热(熔融)至290℃,在约3h内将2-萘磺酸钠加入,直至游离碱含量为5%~6%为止。之后,于320~330℃下保温1h。碱熔物稀释于水中,在70~80℃下通SO2至酚酞无色。加水煮洗,除去亚硫酸钠,再经脱水、减压蒸馏得成品,总收率为73%~74%。
2-异丙萘法
以萘和丙烯为原料,在生产2-萘酚的同时副产丙酮。
【方法三】
(1) 磺化碱熔法。将精萘置于磺化锅,加热(熔融)至140℃。在20min内加入1.085倍(摩尔比)浓硫酸,升温,并在160-164℃下保温2.5h。当2-萘磺酸含量达66%以上、总酸度为25%-27%时结束反应。磺化物于水解锅中在140-150℃下水解1h。然后在中和锅中,在80-90℃下用亚硝酸氢钠溶液中和至刚果红试纸不变蓝为止。用蒸汽和空气驱除SO2气体,降温至30-40℃后吸滤,并用10%的食盐水洗涤后再吸滤得2-萘磺酸钠。
将氢氧化钠置于碱熔锅中,加热(熔融)至290℃,在约3h内将2-萘磺酸钠加入,直至游离碱含量为5%-6%为止。之后于320-330℃下保温1h。碱熔物稀释于水中,在70-80℃下通SO2至酚酞无色。加水煮洗,除去亚硫酸钠,再经脱水、减压蒸馏得成品,总收率为73%-74%.。
(2)2-异丙萘法。以萘和丙烯为原料,再生产2-萘酚的同时副产丙酮。
【方法四】
由萘经磺化、碱熔制得。磺化碱熔法是国内外广泛采用的生产方法,但腐蚀严重,成本较高,废水生物氧耗量高。美国氰胺公司开发的2-异丙萘法,以萘和丙烯为原料,在生产2-萘酚的同时副产丙酮,这方法与异丙苯法制苯酚的情况类似。原料消耗定额:精萘1170kg/t、硫酸1080kg/t、固体烧碱700kg/t。
2-萘酚海关
[ 海关编码 ]: 2907151000
[ 中文概述 ]:
HS:2907151000 β-萘酚(2-萘酚) 增值税率:17.0% 退税率:9.0% 监管条件:无 最低关税:5.5% 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
HS:2907151000 naphthalen-2-ol VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
2-萘酚文献
J. Chromatogr. A. 1350 , 102-11, (2014)
A high-performance TLC (HPTLC) method was newly developed and validated for analysis of 7 steviol glycosides in 6 different types of food and Stevia formulations. After a minimized one-step sample pre...
Development of a novel magnetic molecularly imprinted polymer coating using porous zeolite imidazolate framework-8 coated magnetic iron oxide as carrier for automated solid phase microextraction of estrogens in fish and pork samples.J. Chromatogr. A. 1365 , 35-44, (2014)
A high-performance magnetic molecularly imprinted polymer (MIP) coating using zeolite imidazolate framework-8 coated magnetic iron oxide (Fe3O4@ZIF-8) as a carrier was developed for simultaneous autom...
QSAR study and synthesis of new phenyltropanes as ligands of the dopamine transporter (DAT).Bioorg. Med. Chem. 20 , 1388-95, (2012)
The dopamine transporter (DAT) plays a pivotal role in the regulation of dopamine neurotransmission, and is involved in a number of physiological functions and brain disorders. Furthermore the DAT ana...
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推荐生产厂家/供应商:
公司名:上海化源生化科技有限公司
区域:上海市普陀区
价格:
联系人:化源
产品详情:2-萘酚
公司名:南通润丰石油化工有限公司
区域:南通市崇川区
价格:
¥需询单/1kg
¥需询单/1ton
联系人:曹经理
产品详情:2-萘酚
公司名:上海吉至生化科技有限公司
区域:上海市奉贤区
价格:
¥138.0/500g
联系人:刘佳
产品详情:β-萘酚
公司名:上海脉铂医药科技有限公司
区域:上海市嘉定区
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¥489.0/5g
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¥需询单/1g
¥需询单/1g
联系人:李先生
产品详情:2-Naphthol
公司名:上海阿拉丁生化科技股份有限公司
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¥38.9/100g
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相关化合物
【2-萘酚】化源网提供2-萘酚CAS号135-19-3,2-萘酚MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询2-萘酚上化源网,专业又轻松。>>电脑版:2-萘酚
标题:2-萘酚_MSDS_用途_密度_2-萘酚CAS号【135-19-3】_化源网 地址:https://m.chemsrc.com/mip/cas/135-19-3_954656.html