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4-氯-1-丁醇

4-氯-1-丁醇用途

用作溶剂、有机合成中间体。

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4-氯-1-丁醇名称

[ CAS 号 ]:
928-51-8

[ 中文名 ]:
4-氯丁醇

[ 英文名 ]:
4-Chloro-1-butanol

[中文别名 ]:

[英文别名 ]:

4-CHLOROBUTANOL
4-Chloro-1-butanol
1-Butanol,4-chloro
MFCD00002967
4-Choro-1-bytanol
4-Chlorobutane-1-ol
EINECS 213-175-5
4-Chlorolbutanol
1-chlorobutanol
tetramethylene chlorohydrin

4-氯-1-丁醇物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
178.5±0.0 °C at 760 mmHg

[ 分子式 ]:
C₄H₉ClO

[ 分子量 ]:
108.567

[ 闪点 ]:
77.2±18.0 °C

[ 精确质量 ]:
108.034195

[ PSA ]:
20.23000

[ LogP ]:
0.85

[ 外观性状 ]:
略黄色液体

[ 蒸汽压 ]:
0.3±0.7 mmHg at 25°C

[ 折射率 ]:
1.434

[ 储存条件 ]:
库房低温通风干燥,防明火,防高温,与氧化剂分开存放

4-氯-1-丁醇MSDS

4-氯-1-丁醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EL1325000

CHEMICAL NAME :: 1-Butanol, 4-chloro-

CAS REGISTRY NUMBER :: 928-51-8

BEILSTEIN REFERENCE NO. :: 1731408

LAST UPDATED :: 199710

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C4-H9-Cl-O

MOLECULAR WEIGHT :: 108.58

WISWESSER LINE NOTATION :: Q4G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 990 mg/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Gastrointestinal - ulceration or bleeding from stomach Liver - other changes

REFERENCE :: ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1955- Volume(issue)/page/year: 26,17,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JOCEAH Journal of Organic Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1936- Volume(issue)/page/year: 21,739,1956 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3650 mg/kg/8W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 39,391,1979

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4-氯-1-丁醇安全信息

[ 符号 ]:

GHS02, GHS05, GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H226-H290-H302-H315-H319-H335-H351

[ 警示性声明 ]:
P210-P280-P301 + P312 + P330-P305 + P351 + P338-P370 + P378

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R10;R20/21/22;R36/37/38

[ 安全声明 (欧洲) ]:
S23-S24/25-S36/37/39-S26-S16

[ 危险品运输编码 ]:
UN 2920 8/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
EL1325000

[ 包装等级 ]:
III

[ 危险类别 ]:
3.2

[ 海关编码 ]:
29055910

4-氯-1-丁醇合成路线

4-氯-1-丁醇上下游产品

4-氯-1-丁醇上游产品

4-氯-1-丁醇下游产品

4-氯-1-丁醇制备

由四氢呋喃与氯化氢反应而得：在四氢呋喃沸腾的情况下，慢慢通入氯化氢气体。随着反应的进行，反应液温度逐渐升高，直至100℃以上。当温度停留在103.5-105.5℃稳定时，即反应结束。减压分馏，收集80-90℃（1.87kPa）馏分得粗品；再进行减压分馏，收集81-82℃（1.87kPa）馏分得成品，产率为54%-57%。

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4-氯-1-丁醇海关

[ 海关编码 ]: 2905590090

[ 中文概述 ]:
2905590090 其他无环醇的卤化、磺化等衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2905590090 other halogenated, sulphonated, nitrated or nitrosated derivatives of acyclic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

4-氯-1-丁醇文献

Reichardt's dye and its reactions with the alkylating agents 4-chloro-1-butanol, ethyl methanesulfonate, 1-bromobutane and Fast Red B - a potentially useful reagent for the detection of genotoxic impurities in pharmaceuticals.

J. Pharm. Pharmacol. 61(4) , 533-7, (2009)

Alkylating agents are potentially genotoxic impurities that may be present in drug products. These impurities occur in pharmaceuticals as by-products from the synthetic steps involved in drug producti...

Development and validation of a sensitive GC-MS method for the determination of alkylating agent, 4-chloro-1-butanol, in active pharmaceutical ingredients.

Chem. Pharm. Bull. 62(4) , 395-8, (2014)

The analysis of genotoxic impurities (GTIs) in active pharmaceutical ingredients (APIs) is a challenging task. The target detection limit (DL) in an API is typically around 1 ppm (1 µg/g API). Therefo...

更多文献

4-氯-1-丁醇

4-氯-1-丁醇用途

4-氯-1-丁醇名称

4-氯-1-丁醇物理化学性质

4-氯-1-丁醇MSDS

详细MSDS(安全技术说明书)

4-氯-1-丁醇毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

4-氯-1-丁醇安全信息

4-氯-1-丁醇合成路线

详细合成路线

4-氯-1-丁醇上下游产品

4-氯-1-丁醇上游产品

4-氯-1-丁醇下游产品

4-氯-1-丁醇制备

4-氯-1-丁醇海关

4-氯-1-丁醇文献

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