Suc-Leu-Tyr-AMC

Suc-Leu-Tyr-AMC用途

Suc-Leu-Tyr-AMC is a fluorescent substrate for calpain I and II and papain (another cysteine protease) that is used for measuring the chymotrypsin-like peptidase activity of the 20S proteasome

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Suc-Leu-Tyr-AMC名称

[ CAS 号 ]:
94367-20-1

[ 中文名 ]:
N-琥珀酰基-亮氨酰-酪氨酸-7-胺基-4-甲基香豆素

[ 英文名 ]:
Suc-Leu-Tyr-AMC

[英文别名 ]:

CALPAIN SUBSTRATE II,FLUOROGENIC
N-SUCCINYL-LEU-TYR 4-METHYLCOUMARYL-7-AMIDE
succinyl-leucyl-tyrosyl-4-methyl-7-coumarylamide
N-SUCCINYL-LEU-TYR 7-AMIDO-4-METHYLCOUMARIN
CALPAIN SUBSTRATE I
SUC-LEU-TYR-AMC
SUC-LY-AMC
SUCCINYL-LEU-TYR-AMC
SUC-LEU-TYR-7-AMINO-4-METHYLCOUMARIN
MFCD00057900

Suc-Leu-Tyr-AMC物理化学性质

[ 密度 ]:
1.324g/cm3

[ 沸点 ]:
945.5ºC at 760mmHg

[ 分子式 ]:
C₂₉H₃₃N₃O₈

[ 分子量 ]:
551.58800

[ 闪点 ]:
525.6ºC

[ 精确质量 ]:
551.22700

[ PSA ]:
175.04000

[ LogP ]:
3.72350

[ 折射率 ]:
1.611

[ 储存条件 ]:
−20°C

Suc-Leu-Tyr-AMCMSDS

详细MSDS(安全技术说明书)

Suc-Leu-Tyr-AMC安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

Suc-Leu-Tyr-AMC文献

Comparative specificity and kinetic studies on porcine calpain I and calpain II with naturally occurring peptides and synthetic fluorogenic substrates.

J. Biol. Chem. 259 , 12489, (1984)

Homogeneous porcine calpain (Ca2+-dependent cysteine proteinase) was found to hydrolyze a variety of peptides and synthetic substrates. Leu-Trp-Met-Arg-Phe-Ala, eledoisin-related peptide, alpha-neoend...

Inhibition of chicken calpain II by proteins of the cystatin superfamily and alpha 2-macroglobulin.

Biochem. J. 248(2) , 589-94, (1987)

Inhibition of chicken calpain II by proteins of the cystatin superfamily and alpha 2-macroglobulin was investigated. Human liver cystatins A and B, human cystatin C, chicken cystatin and rat T-kininog...

Probing of primed and unprimed sites of calpains: Design, synthesis and evaluation of epoxysuccinyl-peptide derivatives as selective inhibitors.

Eur. J. Med. Chem. 82 , 274-80, (2014)

Calpains are intracellular cysteine proteases with important physiological functions. Up- or downregulation of their expression can be responsible for several diseases, therefore specific calpain inhi...

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