邻二甲苯

邻二甲苯用途

【用途一】
主要用于生产邻苯二甲酸酐
【用途二】
用作色谱标准物质和溶剂
【用途三】
邻二甲苯是杀菌剂灭锈胺、四氯苯肽和除草剂苄嘧磺隆的原料，用以制造邻甲基苯甲酸作为中间体。
【用途四】
主要用作化工原料和溶剂。可用于生产苯酐、染料、杀虫剂和药物，如维生素等。亦可用作航空汽油添加剂。
【用途五】
用于生产邻二甲酸酐、染料、杀虫剂，也可作溶剂用。主要用作化工原料和溶剂。可用于生产苯酐；染料；杀虫剂和药物，如维生素等。亦可用作航空汽油添加剂。
【用途六】
用于生产邻二甲酸酐、染料、杀虫剂，也可作溶剂用。主要用作化工原料和溶剂。可用于生产苯酐；染料；杀虫剂和药物，如维生素等。亦可用作航空汽油添加剂。用于ICP-AES、AAS、AFS、ICP-MS、离子色谱等。滴定分析用标准溶液。校准仪器和装置；评价方法；工作标准；质量保证/质量控制；其他。

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邻二甲苯名称

[ CAS 号 ]:
95-47-6

[ 中文名 ]:
邻二甲苯

[ 英文名 ]:
o-xylene

[中文别名 ]:

1,2-二甲苯

[英文别名 ]:

Orthoxylene
1,2-Dimethylbenzene
1,2-dimethyl-benzene
o-Xylol
MFCD00008519
O-Dimethylbenzene
ortho-Dimethylbenzene
1,2-Xylene
EINECS 202-422-2

邻二甲苯物理化学性质

[ 密度 ]:
0.879

[ 沸点 ]:
144 ºC

[ 熔点 ]:
-25 ºC

[ 分子式 ]:
C₈H₁₀

[ 分子量 ]:
106.165

[ 闪点 ]:
31 ºC

[ 精确质量 ]:
106.078247

[ LogP ]:
3.14

[ 外观性状 ]:
无色液体

[ 蒸汽密度 ]:
3.7 (vs air)

[ 蒸汽压 ]:
6.0±0.1 mmHg at 25°C

[ 折射率 ]:
1.500

[ 储存条件 ]:
库房通风低温干燥,轻装轻卸、与氧化剂和酸类分开存放

[ 稳定性 ]:
Stable. Incompatible with oxidizing agents. Flammable. Hygroscopic.

[ 水溶解性 ]:
水溶性：不溶；水溶解度：178 mg/l 25 °C；混溶：丙酮,乙醚,醇

邻二甲苯MSDS

详细MSDS(安全技术说明书)

邻二甲苯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ZE2450000

CHEMICAL NAME :: o-Xylene

CAS REGISTRY NUMBER :: 95-47-6

LAST UPDATED :: 199712

DATA ITEMS CITED :: 28

MOLECULAR FORMULA :: C8-H10

MOLECULAR WEIGHT :: 106.18

WISWESSER LINE NOTATION :: 1R B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human

DOSE/DURATION :: 6125 ppm/12H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 22,883,1980

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 22,883,1980

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6125 ppm/12H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPBAA7 Journal of Pathology and Bacteriology. (London, UK) V.1-96, 1892-1968. For publisher information, see JPTLAS. Volume(issue)/page/year: 46,95,1938

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 30 gm/m3

TOXIC EFFECTS :: Behavioral - general anesthetic Lungs, Thorax, or Respiration - respiratory depression Cardiac - other changes

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 143,223,1929

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1550 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 58,106,1985

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPBAA7 Journal of Pathology and Bacteriology. (London, UK) V.1-96, 1892-1968. For publisher information, see JPTLAS. Volume(issue)/page/year: 46,95,1938

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPBAA7 Journal of Pathology and Bacteriology. (London, UK) V.1-96, 1892-1968. For publisher information, see JPTLAS. Volume(issue)/page/year: 46,95,1938 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 150 mg/m3/24H

SEX/DURATION :: female 7-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord)

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 18,61,1980

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 1500 mg/m3/24H

SEX/DURATION :: female 7-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 18,61,1980

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 3000 mg/m3/24H

SEX/DURATION :: female 7-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 18,61,1980

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 500 mg/kg

SEX/DURATION :: male 2 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

REFERENCE :: ARANDR Archives of Andrology. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1978- Volume(issue)/page/year: 11,233,1983

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 500 mg/m3/12H

SEX/DURATION :: female 6-15 day(s) after conception

REFERENCE :: ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978- Volume(issue)/page/year: 8,425,1985 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-STEL 651 mg/m3 (150 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 434 mg/m3 (100 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 47,75,1978 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 100 ppm (440 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,281,1971 OSHA PEL (Gen Indu):8H TWA 100 ppm (435 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 100 ppm (435 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 100 ppm (435 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 100 ppm (435 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO o-XYLENE-air:10H TWA 100 ppm;STEL 150 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1026 No. of Facilities: 179 (estimated) No. of Industries: 9 No. of Occupations: 25 No. of Employees: 5778 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1026 No. of Facilities: 2608 (estimated) No. of Industries: 30 No. of Occupations: 28 No. of Employees: 25994 (estimated) No. of Female Employees: 5812 (estimated)

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邻二甲苯安全信息

[ 符号 ]:

GHS02, GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H226-H304-H312 + H332-H315-H319-H335-H412

[ 警示性声明 ]:
P210-P261-P273-P301 + P310-P302 + P352 + P312-P331

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R10;R20/21;R38

[ 安全声明 (欧洲) ]:
S25-S45-S36/37-S16-S7

[ 危险品运输编码 ]:
UN 1307 3/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
ZE2450000

[ 包装等级 ]:
II

[ 危险类别 ]:
3

[ 海关编码 ]:
2902410000

邻二甲苯合成路线

详细合成路线

邻二甲苯上下游产品

邻二甲苯上游产品

邻二甲苯下游产品

邻二甲苯制备

1.工业上采用超精馏的方法从混合二甲苯中分离出邻二甲苯。邻二甲苯与混合二甲苯中其他组分的沸点相差5℃以上，精馏时需要塔板数约150，回流比5-8，需消耗较多能量。由分馏煤焦油的轻油部分或催化重整轻油经分馏，或由甲苯经歧化而成。

2.以工业邻二甲苯为原料，先用工业浓硫酸洗涤至酸层无色，再依次用10%氢氧化钠溶液、水洗涤至合格，分出水层后用无水氯化钙干燥，然后精馏，待馏出物清亮后，收集中间馏分，即为纯品。

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邻二甲苯海关

[ 海关编码 ]: 2902410000

[ 中文概述 ]:
2902410000 邻二甲苯。监管条件:无。增值税率:17.0%。退税率:9.0%。最低关税:2.0%。普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量

[ Summary ]:
2902410000 o-xylene。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:2.0%。General tariff:20.0%

邻二甲苯文献

G-protein-coupled estrogen receptor 1 is anatomically positioned to modulate synaptic plasticity in the mouse hippocampus.

J. Neurosci. 35(6) , 2384-97, (2015)

Both estrous cycle and sex affect the numbers and types of neuronal and glial profiles containing the classical estrogen receptors α and β, and synaptic levels in the rodent dorsal hippocampus. Here, ...

Intraplacental gene therapy with Ad-IGF-1 corrects naturally occurring rabbit model of intrauterine growth restriction.

Hum. Gene Ther. 26(3) , 172-82, (2015)

Intrauterine growth restriction (IUGR) due to placental insufficiency is a leading cause of perinatal complications for which there is no effective prenatal therapy. We have previously demonstrated th...

Correlation of perfusion MRI and 18F-FDG PET imaging biomarkers for monitoring regorafenib therapy in experimental colon carcinomas with immunohistochemical validation.

PLoS ONE 10(2) , e0115543, (2015)

To investigate a multimodal, multiparametric perfusion MRI / 18F-fluoro-deoxyglucose-(18F-FDG)-PET imaging protocol for monitoring regorafenib therapy effects on experimental colorectal adenocarcinoma...

更多文献

邻二甲苯

邻二甲苯用途

邻二甲苯名称

邻二甲苯物理化学性质

邻二甲苯MSDS

详细MSDS(安全技术说明书)

邻二甲苯毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

邻二甲苯安全信息

邻二甲苯合成路线

详细合成路线

邻二甲苯上下游产品

邻二甲苯上游产品

邻二甲苯下游产品

邻二甲苯制备

邻二甲苯海关

邻二甲苯文献

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