2,4,5-三氯苯酚

2,4,5-三氯苯酚用途

【用途一】
可用于制备多种除草剂、杀虫剂、杀菌剂；作为抗菌和防腐剂，广泛用于制备粘合剂、橡胶制品及纺织工业的防腐乳液。它本身可用作消毒剂，它的钠盐也是杀菌剂和防腐剂，用于制造业和皮革工业；在医药上用于合成氯丙炔碘、灭菌酚等。
【用途二】
用作杀霉菌剂、气相色谱对比样品。

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2,4,5-三氯苯酚名称

[ CAS 号 ]:
95-95-4

[ 中文名 ]:
2,4,5-三氯苯酚

[ 英文名 ]:
2,4,5-Trichlorophenol

[中文别名 ]:

2,4,5-三氯酚

[英文别名 ]:

RCRA waste no. U230
Nurelle
2.4.5-Trichlor-1-hydroxy-benzol
Preventol I
Collunosol
2,4,5-Trichloro-phenol
EINECS 202-467-8
2,3-DIHYDRO-1H-CYCLOPENTA[B]QUINOLIN-9-YLAMINE
Phenol,2,4,5-trichloro
2,4,5-Trichlorophenol

2,4,5-三氯苯酚物理化学性质

[ 密度 ]:
1,678 g/cm3

[ 沸点 ]:
248 °C740 mm Hg(lit.)

[ 熔点 ]:
67-69 °C(lit.)

[ 分子式 ]:
C₆H₃Cl₃O

[ 分子量 ]:
197.44600

[ 闪点 ]:
253°C

[ 精确质量 ]:
195.92500

[ PSA ]:
20.23000

[ LogP ]:
3.35240

[ 外观性状 ]:
白色至灰白色结晶固体

[ 折射率 ]:
1.608

[ 储存条件 ]:
库房通风低温干燥,与酸类、氧化剂、食品添加剂分开存放

[ 稳定性 ]:
Stable. Note that this material creates dioxin in alkaline media at elevated temperatures.

2,4,5-三氯苯酚MSDS

2,4,5-三氯苯酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SN1400000

CHEMICAL NAME :: Phenol, 2,4,5-trichloro-

CAS REGISTRY NUMBER :: 95-95-4

BEILSTEIN REFERENCE NO. :: 0607569

LAST UPDATED :: 199710

DATA ITEMS CITED :: 21

MOLECULAR FORMULA :: C6-H3-Cl3-O

MOLECULAR WEIGHT :: 197.44

WISWESSER LINE NOTATION :: QR BG CG EG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 820 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 355 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - body temperature increase

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2260 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 98 gm/kg/98D-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6700 mg/kg/16W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4 gm/kg

SEX/DURATION :: female 8-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - live birth index (measured after birth)

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 150 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 303,101,1993 *** REVIEWS *** IARC Cancer Review:Human Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 41,319,1986 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 20,349,1979 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1866 No. of Facilities: 193 (estimated) No. of Industries: 9 No. of Occupations: 9 No. of Employees: 1272 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1866 No. of Facilities: 184 (estimated) No. of Industries: 11 No. of Occupations: 9 No. of Employees: 895 (estimated) No. of Female Employees: 27 (estimated)

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2,4,5-三氯苯酚安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H410

[ 警示性声明 ]:
P273-P301 + P312 + P330-P305 + P351 + P338-P391-P501

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R22;R36/38;R50/53

[ 安全声明 (欧洲) ]:
S26-S28-S60-S61-S28A-S45-S36/37

[ 危险品运输编码 ]:
UN 3077 9/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
SN1400000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2908199090

2,4,5-三氯苯酚合成路线

2,4,5-三氯苯酚上下游产品

2,4,5-三氯苯酚上游产品

2,4,5-三氯苯酚下游产品

2,4,5-三氯苯酚制备

将2,3,5,6-四氯苯、固碱、甲醇投入高压釜，控制温度在135-152℃，压力为0.5-1.4MPa，保持14h。将反应液冷至60℃，蒸馏回收甲醇，放出残液，冷却结晶，过滤。将结晶溶于水，加热至70℃，加入保险粉，调节pH=9.2-9.6，加入活性炭，于95℃脱色半小时。过滤，滤液冷至15℃以下，加盐酸至pH=2-3，滤取2,4,5-三氯酚，于45℃干燥得成品。

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2,4,5-三氯苯酚海关

[ 海关编码 ]: 2908199090

[ 中文概述 ]:
HS:2908199090 其他酚及酚醇的仅含卤素取代基的衍生物及其盐增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS: 2908199090. derivatives of polyphenols or phenol-alcohols containing only halogen substituents and their salts. VAT:17.0%. tax rebate rate:9.0%. supervision conditions:None. MFN tariff:5.5%. general tariff:30.0%

2,4,5-三氯苯酚文献

Determination of nine environmental phenols in urine by ultra-high-performance liquid chromatography-tandem mass spectrometry.

J. Anal. Toxicol. 36(9) , 608-15, (2012)

A method was developed to determine nine environmental phenols, including bisphenol A, 2,3,4-trichlorophenol, 2,4,5-trichlorophenol, pentachlorophenol, triclosan (2,4,4'-trichloro-2'-hydroxyphenylethe...

Determination of chlorophenols in honey samples using in-situ ionic liquid-dispersive liquid-liquid microextraction as a pretreatment method followed by high-performance liquid chromatography.

Food Chem. 174 , 446-51, (2014)

In-situ ionic liquid-dispersive liquid-liquid microextraction (IL-DLLME) method was developed as a pretreatment method for the detection of six chlorophenols (CPs) in honey samples. The hydrophobic io...

Acute toxicity of organic chemicals to Gammarus pulex correlates with sensitivity of Daphnia magna across most modes of action.

Aquat. Toxicol. 103(1-2) , 38-45, (2011)

We investigated the sensitivity of the freshwater crustacean amphipod Gammarus pulex towards organic xenobiotic compounds in comparison to the sensitivity of the crustacean cladoceran Daphnia magna. I...

更多文献

2,4,5-三氯苯酚

2,4,5-三氯苯酚用途

2,4,5-三氯苯酚名称

2,4,5-三氯苯酚物理化学性质

2,4,5-三氯苯酚MSDS

详细MSDS(安全技术说明书)

2,4,5-三氯苯酚毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

2,4,5-三氯苯酚安全信息

2,4,5-三氯苯酚合成路线

详细合成路线

2,4,5-三氯苯酚上下游产品

2,4,5-三氯苯酚上游产品

2,4,5-三氯苯酚下游产品

2,4,5-三氯苯酚制备

2,4,5-三氯苯酚海关

2,4,5-三氯苯酚文献

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